Duo Tablet Sustained Release 10/500 mg

Adult dose

This medication is generally administered once daily with the evening meal. The maximum dose is 10 mg of dapagliflozin and 2000 mg of sustained-release metformin given once daily, administered as 2 tablets of 5 mg/1000 mg. If there is no prior experience with diabetes medication, the initial regimen is to take 1 tablet of either 5 mg/500 mg or 10 mg/500 mg once daily. To reduce gastrointestinal side effects of metformin, dosage should be adjusted gradually.

This medication is used for the treatment of diabetes and contains two components: metformin and dapagliflozin. When taking this medication, caution is advised as lactic acidosis, a serious side effect, can occur very rarely. Lactic acidosis is a condition where excessive lactic acid accumulates in the body, which can be life-threatening. Also, there is a risk of hypoglycemia when taken with insulin or sulfonylurea medications, so blood sugar levels should be closely monitored. Patients with poor kidney function, dehydration, severe infections, or decreased heart function should not take this medication. Patients whose kidney function is moderate to severely impaired, as well as those with acute illnesses or scheduled surgeries, should discontinue taking this medication and can begin again only after confirming normal kidney function. Women who are pregnant or breastfeeding and patients with certain genetic disorders such as lactose intolerance should not take this medication. This medication should be administered with caution to patients at risk of volume depletion or hypotension, and elderly patients or those with decreased kidney function should be particularly careful. While taking this medication, there may be interactions with other medications that can affect blood sugar control, so all medications being taken should be disclosed to healthcare providers. During the use of this medication, genital infections or urinary tract infections may occur, so if symptoms of infection appear, immediate consultation with healthcare providers is necessary. Moreover, vitamin B12 deficiency may occur, so it is advisable to monitor blood vitamin B12 levels during prolonged use. Excessive alcohol consumption may increase the risk of side effects from this medication, so it should be avoided. This medication has not been established for safety and efficacy in children, so it is not used for them. Dizziness or hypotensive symptoms may occur during use, so caution is advised when driving or operating machinery. Lastly, this medication should be stored out of reach of children and should be kept in its original container for safety.

Serious side effects

• Lactic acidosis
• severe hypoglycemia
• acute renal failure
• intravascular volume depletion
• hypotension
• diabetic ketoacidosis
• urosepsis
• pyelonephritis
• Guillain-Barre syndrome
• severe allergic reaction

Mild side effects

Vulvovaginitis, balanititis and related genital infections, urinary tract infections, fungal infections, hypoglycemia, dry mouth, dizziness, constipation, back pain, dysuria, polyuria, nocturia, vulvar itching, genital itching, elevated hematocrit, increased serum creatinine, dyslipidemia, diarrhea, nausea/vomiting, vitamin B12 decrease/deficiency, epigastric pain, dyspepsia, abdominal discomfort, abdominal pain, gastric ulcer, irritable bowel syndrome, sialadenitis,

This medication should be stored in a tightly sealed container to protect it from air and moisture. The storage temperature should ideally be maintained at room temperature between 1 degree and 30 degrees Celsius.

Appearance

Pink, biconvex, rectangular film-coated tablet

Package unit

30 tablets/box [(6 tablets/PTP)x5], 28 tablets/box [(7 tablets/PTP)x4]