Sitagliptin 50 mg (Sitagliptin Phosphate Hydrate)

Adult dose

This medication is administered at a dose of 100 mg once a day either as monotherapy or in combination therapy, with a maximum daily dose of 100 mg. This medication can be taken regardless of meals. For patients with renal impairment, dosage adjustments are necessary based on renal function. - In patients with mild renal impairment (eGFR 60 to < 90), no dosage adjustment is required. - In patients with moderate renal impairment (eGFR 45 to < 60), no dosage adjustment is required.

This medication may cause serious allergic reactions in some patients; therefore, if symptoms such as skin rash, difficulty breathing, or swelling of the face or neck occur after taking the medication, it should be discontinued immediately and a doctor consulted. While taking this medication, inflammation of the pancreas, known as pancreatitis, may occur; patients should inform their healthcare provider immediately if symptoms such as abdominal pain, nausea, or vomiting arise. This medication should not be used in patients with type 1 diabetes or diabetic ketoacidosis, and should not be taken if allergic to this medication or its ingredients. Patients with impaired kidney function may need dosage adjustments, so they should take it according to a doctor's instructions. This medication can be used alone or with other diabetes treatments, but some patients may experience hypoglycemia; thus, blood sugar levels should be monitored regularly. In clinical trials, side effects such as headache, upper respiratory infections, rhinitis, and diarrhea have been reported; if these symptoms are persistent or worsen, consult a healthcare provider. This medication is not recommended for pregnant or nursing women, so it is important to consult a doctor before taking it. Elderly patients may have reduced kidney function, so regular monitoring of kidney function while taking this medication is important. In case of an overdose, seek immediate medical attention for appropriate treatment, and some drugs may be removed through hemodialysis if necessary. Care should be taken when taking this medication with specific drugs (e.g., insulin, sulfonylureas) as the risk of hypoglycemia may increase; hence, dosage adjustments should be made according to a doctor's instructions. If symptoms such as joint pain or skin blisters occur while taking this medication, notify a doctor immediately, and if necessary, medication may be discontinued.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, anaphylaxis, severe hypersensitivity reactions, Stevens-Johnson syndrome, severe skin reactions (exfoliative skin disease), acute pancreatitis (fatal/non-fatal hemorrhagic or necrotizing pancreatitis), severe edema, acute renal failure, jaundice (liver abnormalities), severe and disabling arthralgia, blistering similar to pemphigus, rhabdomyolysis, severe allergic reactions, serious

Mild side effects

• Hypoglycemia
• upper respiratory infection
• rhinitis
• headache
• diarrhea
• nausea
• abdominal pain
• constipation
• vomiting
• muscle pain

This medication should be stored in a tightly sealed container that is well-ventilated and kept at room temperature between 1 to 30 degrees Celsius. Proper storage helps maintain the efficacy of the medication and prevent deterioration.

Appearance

Light beige, round film-coated tablet

Package unit

PTP - 30 tablets/box [10 tablets/PTP x 3]