Sitagliptin Phosphate Hydrate 25 mg Tablet

Adult dose

In monotherapy or combination therapy, administer 100 mg once daily, with a maximum daily dose of 100 mg. It can be taken regardless of meals. In cases of renal impairment, dosage adjustments are required if glomerular filtration rate (eGFR) is below 45 mL/min/1.73 m2. For patients with mild to moderate renal impairment (eGFR 45 or higher but less than 90), dosage adjustment is not necessary. For moderately impaired patients (eGFR 30 or higher but less than 45), administer 50 mg once daily.

This medication can cause severe allergic reactions, so if symptoms such as rash, difficulty breathing, or swelling of the face or neck appear after taking the medication, you must immediately stop taking it and consult a doctor. In addition, acute pancreatitis, a serious inflammation of the pancreas, may occur; therefore, if abdominal pain, vomiting, or persistent discomfort in the abdomen occurs, quickly inform medical personnel. This medication should not be used in patients with type 1 diabetes or diabetic ketoacidosis, nor should it be taken by individuals with an allergy to the active ingredient. Patients with impaired renal function may have delayed excretion of this medication, so dosage adjustments should be made cautiously. During treatment, side effects such as cold symptoms, headaches, indigestion, and diarrhea may occur, and especially when taken with other blood sugar-lowering agents, hypoglycemia symptoms may occur more frequently. Hypoglycemia symptoms include dizziness, cold sweat, and severe fatigue, so caution is needed. This medication can also be used in the elderly, but regular kidney function tests should be conducted, and pregnant or breastfeeding women are advised not to take it. In case of overdose, general treatment should be conducted along with monitoring the heart condition, and if necessary, dialysis may be performed to remove the medication. Rare side effects such as joint pain or skin diseases may develop during long-term use, so inform a doctor if any unusual symptoms occur. Finally, there are minimal special interactions when used in combination with other medications, but it is important to consult medical personnel if taking specific medications.

Serious side effects

Urticaria, severe swelling (edema), anaphylaxis, angioedema, severe allergic reactions, exfoliative skin disease (including Stevens-Johnson syndrome), rash, chest tightness, difficulty breathing, cold sweat, pallor, acute pancreatitis (including hemorrhagic or necrotizing pancreatitis), acute renal failure, severe and disabling arthralgia, blistering pemphigoid, liver abnormalities (including elevated liver enzymes, jaundice), serious neurological symptoms, severe edema

Mild side effects

• Upper respiratory tract infection
• nasopharyngitis
• headache
• constipation
• vomiting
• myalgia
• limb pain
• back pain
• pruritus
• thrombocytopenia

This medication should be stored in a tightly closed container to prevent air or moisture from entering, and it is best to store it at room temperature between 1 and 30 degrees Celsius. By doing so, the effectiveness of the medication can be maintained and deterioration can be prevented.

Appearance

Pink-colored round film-coated tablet

Package unit

PTP - 30 tablets/box [(10 tablets/PTP x 3)]