Janumet M Tablets 50/1000 mg (Sitagliptin Phosphate / Metformin Hydrochloride)

Adult dose

This medication is generally taken twice daily with food. Patients currently not treated with metformin should begin with an initial dose of 50/500 mg, 1 tablet, taken twice daily, with an increase to 50/1000 mg possible. Patients being treated with metformin should start at 50 mg of sitagliptin twice daily, along with their usual dose of metformin.

This medication is used in the treatment of diabetes and contains two ingredients: sitagliptin and metformin. While taking this medication, serious allergic reactions may occur, so if you experience symptoms such as skin rash or difficulty breathing, you must stop taking it immediately and consult a doctor. There is a risk of pancreatitis, which is inflammation of the pancreas; therefore, if abdominal pain, vomiting, or severe abdominal pain occurs, visit a hospital immediately. It may be dangerous to take this medication for patients with significantly impaired kidney function or those with severe infections or dehydration, so they should not take it. Additionally, if you are undergoing radiological examinations using contrast agents, you must temporarily stop taking this medication before and after the tests and restart only after confirming normal kidney function. It is safer for women who are pregnant or breastfeeding to avoid taking this medication. During treatment, symptoms of hypoglycemia may appear, so especially when taking it with other diabetes medications, monitor blood sugar levels frequently and take immediate action if symptoms arise. This medication may cause side effects such as gastrointestinal disorders, diarrhea, nausea, headache, etc., so if symptoms are severe, consult a doctor. Patients with liver or kidney problems have a higher risk of side effects from this medication, so regular blood tests and kidney function tests must be conducted for monitoring. It is important to avoid excessive alcohol consumption, and this medication should be temporarily stopped when undergoing surgery or during severe illness. Additionally, regularly check vitamin B12 levels while taking this medication, and supplementation may be needed if levels are low. The safety and efficacy of this medication have not been sufficiently established in children, so it is advisable not to administer it to children under 18 years of age. Elderly patients may have reduced kidney function, so it is important to periodically check kidney function before and during treatment and adjust the dosage accordingly. In case of overdose, seek medical attention immediately and dialysis treatment may be necessary. Finally, while taking this medication, adhere to the prescribed method and dosage, and do not arbitrarily stop or change the dosage without consulting a doctor.

Serious side effects

Urticaria, angioedema, anaphylaxis, rash, Steven-Johnson syndrome including exfoliative skin disorders, acute pancreatitis, lactic acidosis, severe hypoglycemia, acute renal failure, difficulty breathing, unstable angina, severe and disabling arthralgia, bullous pemphigoid, thrombocytopenia, rhabdomyolysis, elevated liver enzymes, acute renal failure, urticaria, cutaneous vasculitis, jaundice, severe neurological symptoms (e.g., altered consciousness

Mild side effects

• Diarrhea
• nausea
• vomiting
• abdominal pain
• upper respiratory infection
• nasopharyngitis
• headache
• hypoglycemia
• constipation
• weakness

This medication should be stored in a sealed container to prevent air from entering, and it is best to keep it at a temperature between 1 degree and 30 degrees Celsius. This helps maintain the efficacy of the medication and prevent deterioration.

Appearance

Red oval film-coated tablet

Package unit

30 tablets/box [(10 tablets/PTP) × 3]