Ilsung Sitagliptin Tablet 50 mg (Sitagliptin Phosphate)

Adult dose

This medication is administered once daily at a dose of 100 mg for monotherapy or combination therapy, with a maximum daily dose of 100 mg. It can be taken regardless of meals. For patients with moderate renal impairment (eGFR 30-45 mL/min/1.73 m2), a dose of 50 mg is administered once daily. For patients with severe renal impairment or end-stage renal disease (eGFR 15-30 mL/min/1.73 m2 or less)

This medication can rarely cause serious allergic reactions. If symptoms such as sudden rash, difficulty breathing, or swelling of the face or neck occur after taking this medication, usage should be discontinued immediately and a physician should be consulted. Acute pancreatitis may occur during treatment with this medication, so immediate medical attention is necessary if symptoms such as sudden abdominal pain, vomiting, or nausea appear. It should not be administered to patients with type 1 diabetes or diabetic ketoacidosis, and usage should be avoided in cases of severe allergy to this medication or its components. Patients with impaired kidney function should have their dosage adjusted based on their renal function, as the drug may remain in the body longer. It is important to conduct kidney function tests before and during treatment. Symptoms of hypoglycemia may occur when this medication is taken alone or in combination with other antidiabetic agents, so blood sugar should be monitored frequently, and appropriate action should be taken if hypoglycemia symptoms occur. During treatment with this medication, symptoms such as headache, upper respiratory infection, nasopharyngitis, diarrhea, nausea may occur. If symptoms are severe or persist for a long time, consultation with medical personnel is recommended. In particular, when used in conjunction with insulin or sulfonylureas, the risk of hypoglycemia is increased; thus, adjustments to the dosages of these medications may be necessary. This medication is not recommended for use in pregnant or breastfeeding women, so patients should consult their physician if they plan to become pregnant or are currently pregnant. Safety and efficacy in children and adolescents have not been established, so use is not advised. Elderly patients may have reduced kidney function; thus, dosage adjustment and kidney function testing may be required. In case of overdose, immediate treatment at a medical institution is necessary, and this medication may be partially removed by hemodialysis. Additionally, if symptoms such as joint pain or skin blisters occur during treatment with this medication, the physician should be notified immediately, and discontinuation of the medication may be necessary. This medication has relatively few interactions with other specific medications; however, caution is needed when taken with certain drugs such as digoxin or cyclosporine. Lastly, regular medical check-ups should be maintained during treatment with this medication to closely observe any adverse reactions or changes in symptoms.

Serious side effects

Urticaria, severe swelling (edema), anaphylaxis, angioedema, rash, severe allergic reactions, Stevens-Johnson syndrome, blisters, skin peeling, pain in the mucous membranes of the mouth/eyes, severe skin adverse reactions, acute pancreatitis, elevated liver enzymes, jaundice, liver abnormalities, acute kidney failure, difficulty breathing, respiratory problems, moderate to severe joint pain, bullous pemphigoid, thrombocytopenia, rhabdomyolysis, cardiac arrest, severe

Mild side effects

• Nasopharyngitis
• upper respiratory infection
• headache
• diarrhea
• nausea
• abdominal pain
• constipation
• vomiting
• muscle pain
• limb pain

This medication should be stored in a tightly sealed container to prevent air and moisture ingress, ideally at room temperature between 1 degree and 30 degrees Celsius. Proper storage can help maintain the effectiveness of the medication for a longer period.

Appearance

Biconvex round film-coated tablet, light beige in color

Package unit

30 tablets/box [(10 tablets/PTP x 3 packages)]