Sitagliptin Tablets 50 mg (Sitagliptin Phosphate)

Adult dose

This medication is administered at a dosage of 100 mg once daily for monotherapy or combination therapy, with a maximum daily dose of 100 mg. This drug can be taken without regard to meals. Dosage Adjustment in Patients with Renal Impairment: 1. In patients with mild renal impairment (eGFR ≥ 60 mL/min/1.73 m² and < 90 mL/min/1.73 m²), no dosage adjustment is needed. 2. In patients with moderate renal impairment (eGFR ≥ 45 mL/min/1.73 m² and < 60 mL/min/1.73 m²), no dosage adjustment is needed.

This medication may cause allergic reactions; if rash, difficulty breathing, swelling, or other symptoms appear, usage should be stopped immediately and a doctor should be consulted. While taking this medication, inflammation of the pancreas, known as pancreatitis, may occur. If symptoms such as abdominal pain, vomiting, or nausea arise, inform healthcare professionals immediately. This medication should not be used in patients with type 1 diabetes or diabetic ketoacidosis, and it should be avoided in patients with allergies to this medication or its components. Patients with impaired kidney function may need to adjust the dosage of this medication, therefore, it should be taken according to a doctor's instructions. While taking this medication there may be side effects such as upper respiratory infections, nasopharyngitis, headache, diarrhea, nausea, and others; if symptoms worsen, consult a doctor. There is an increased risk of hypoglycemia when this medication is used in combination with other antidiabetic drugs, particularly insulin or sulfonylureas, so it is necessary to monitor blood sugar levels regularly and adjust the dosage as needed. This medication may cause severe joint pain or blistering skin conditions, so if there is severe joint pain or blisters or rashes appear on the skin, inform a doctor immediately. It is advisable for pregnant or breastfeeding women not to use this medication, and safety has not been established for children or adolescents under 18 years of age. Elderly patients may experience decreased kidney function, so renal function tests should be performed before use, and dosage adjusted according to a doctor's guidance. In case of overdose, general treatments such as gastrointestinal decontamination and ECG monitoring may be required, and some drug may be removed through hemodialysis. This medication has relatively few interactions with other drugs, but when used with digoxin, blood concentration should be monitored. If unusual symptoms develop during use, it is important to consult healthcare professionals immediately for appropriate measures.

Serious side effects

Hives, severe swelling (angioedema), anaphylaxis, severe allergic reactions, exfoliative skin diseases (including Stevens-Johnson syndrome), severe rash accompanied by fever, blistering, skin peeling, oral/ocular mucous membrane pain, acute pancreatitis (including hemorrhagic or necrotizing), difficulty breathing, asthma attacks, respiratory distress, liver abnormalities (including jaundice), elevated liver enzyme levels, severe headache, confusion, seizures, visual disturbances, paralysis, severe reactions

Mild side effects

• Nasopharyngitis
• upper respiratory infection
• headache
• diarrhea
• nausea
• abdominal pain
• constipation
• vomiting
• muscle pain
• limb pain

This medication should be stored in a tightly sealed container to prevent air from entering and is best kept at a temperature between 1°C and 30°C. Proper storage will help maintain the medication's efficacy.

Appearance

A round film-coated tablet with a bright beige color and a biconvex shape.

Package unit

30 tablets/box [10 tablets/PTP X 3]