Stargene 50 mg (Sitagliptin Phosphate)

Adult dose

This medication is administered at a dose of 100 mg once daily as monotherapy or in combination therapy, with a maximum daily dose of 100 mg. This medication can be taken regardless of meals. In patients with moderate renal impairment (eGFR ≥ 30 mL/min/1.73 m2 and < 45 mL/min/1.73 m2), a dose of 50 mg once daily is recommended. In patients with severe renal impairment (eGFR ≥ 15 mL/min/1.73 m2 and < 30 mL/min/1.73 m2) or those requiring hemodialysis or peritoneal dialysis (ESRD), a dose of 25 mg once daily is administered. This medication can be given regardless of dialysis timing.

This medication may cause severe hypersensitivity reactions; if symptoms such as skin rash or difficulty breathing occur after administration, discontinue use immediately and consult a physician. This medication may induce acute pancreatitis, so if abdominal pain, vomiting, or severe indigestion occurs, seek medical attention immediately. This drug should not be administered to patients with type 1 diabetes or diabetic ketoacidosis, and it should be avoided in patients with hypersensitivity to this medication or its components. Patients with impaired renal function may require dosage adjustment for this medication, and regular kidney function tests should be conducted following the physician's instructions. Hypoglycemia symptoms may occur during treatment with this medication, especially when taken alongside insulin or sulfonylureas; blood sugar levels should be monitored frequently and precautions against hypoglycemia should be taken. During treatment with this medication, side effects such as headaches, upper respiratory infections, nasopharyngitis, and diarrhea may arise; consult a healthcare professional if symptoms are severe. Pregnant or breastfeeding women are advised to avoid using this medication, as its safety has not been established. Elderly patients should have periodic assessments of their renal function before and during the use of this medication, as they may experience impaired renal function. In cases of overdose, immediate medical attention should be sought to receive appropriate care, as this medication can be partially removed through hemodialysis. Serious adverse effects such as arthralgia or skin disorders can occur in some patients, so any unusual symptoms should be reported to a physician immediately. While there are generally few interactions with other medications, monitoring is necessary if taken with cyclosporine or digoxin based on healthcare provider advice.

Serious side effects

• Hives
• severe swelling (edema)
• anaphylaxis
• angioedema
• rash
• severe allergic reactions
• Stevens-Johnson syndrome
• exfoliative skin disease
• severe skin adverse reactions
• acute pancreatitis

Mild side effects

• Upper respiratory infection
• nasopharyngitis
• constipation
• vomiting
• headache
• muscle pain
• limb pain
• back pain
• pruritus
• thrombocytopenia

This medication should be stored in a tightly sealed container to prevent air exposure and safely kept at a temperature between 1 to 30 degrees Celsius. Proper storage will help maintain the medication's effectiveness and prevent deterioration.

Appearance

Bright beige, biconvex round film-coated tablet

Package unit

30 tablets/box [10 tablets/PTPX3]