Janumet 100 mg (Sitagliptin Phosphate)

Adult dose

This medication is administered once daily at a dose of 100 mg, with a maximum daily dosage of 100 mg. In patients with kidney impairment, dosage adjustments are required based on renal function. - Mild renal impairment (eGFR 60 or above but less than 90): No dosage adjustment needed. - Moderate renal impairment (eGFR 45 or above but less than 60): No dosage adjustment needed. - Moderate renal impairment (eGFR 30 or above but less than 45): 1

This medication may result in severe allergic reactions after administration, so if symptoms such as skin rash or difficulty breathing occur, use should be discontinued immediately and a doctor should be consulted. This medication carries the risk of causing acute pancreatitis, a serious inflammation of the pancreas, therefore, prompt medical attention should be sought if symptoms such as abdominal pain or vomiting appear. This medication should not be used in patients with type 1 diabetes or diabetic ketoacidosis, nor in individuals with known allergies to this medication or its ingredients. Patients with compromised kidney function may need dosage adjustments, and it is important to undergo periodic kidney function tests. Patients in clinical trials on this medication reported symptoms such as upper respiratory tract infections resembling colds, headaches, and nasopharyngitis. When used with other antidiabetic agents, the risk of hypoglycemia may increase; therefore, careful monitoring of blood sugar changes is necessary. Rare side effects such as severe joint pain or bullous pemphigoid resembling skin blisters have been reported, and if such symptoms occur, a doctor should be notified immediately. It is generally advised that pregnant or breastfeeding women do not use this medication, and safety in children or adolescents under 18 has not been established. In case of overdose, seeking immediate medical care for appropriate treatment is necessary, and this medication can be partially removed by hemodialysis. Interactions with other medications are relatively minimal, but it is essential to consult a physician when taken in conjunction with specific drugs. Elderly patients may have reduced kidney function, therefore, dosage adjustments and kidney function assessments are crucial. This medication is reported not to have issues concerning cardiovascular safety and does not increase the risk of heart-related diseases.

Serious side effects

Hives, severe swelling (angioedema), severe allergic reactions (anaphylaxis), severe skin reactions (Stevens-Johnson syndrome, rash, exfoliative dermatitis), acute pancreatitis (fatal/non-fatal hemorrhagic or necrotizing pancreatitis), difficulty breathing, liver dysfunction (jaundice), severe joint pain and disability, bullous pemphigoid, acute renal failure, severe hypoglycemia, severe edema, thrombocytopenia, rhabdomyolysis, pneumonia

Mild side effects

• Upper respiratory tract infection
• nasopharyngitis
• constipation
• vomiting
• headache
• muscle pain
• limb pain
• back pain
• pruritus
• thrombocytopenia

This medication should be stored in a tightly sealed container to prevent air or moisture from entering, and it is advisable to store it at room temperature between 1 to 30 degrees Celsius. Proper storage helps maintain effectiveness and prevents deterioration.

Appearance

Beige-colored, convex, round film-coated tablet

Package unit

30 tablets/box [(10 tablets/PTP) x 3]