Januriptin 50 mg (Sitagliptin Phosphate)

Adult dose

For monotherapy or combination therapy, administer 100 mg once daily, with a maximum daily dose of 100 mg. It can be taken regardless of meals. For patients with kidney impairment, dose adjustment is required based on renal function. No dose adjustment is necessary for mild renal impairment. For moderate renal impairment (glomerular filtration rate of 30–45 mL/min/1.73 m2), administer 50 mg once daily.

This medication may cause severe allergic reactions, so if symptoms such as skin rash or difficulty breathing occur, discontinue use immediately and consult a physician. Acute pancreatitis, a serious pancreatic disease, may occur, so if symptoms such as abdominal pain or vomiting appear while taking this medication, immediate medical attention should be sought. It should not be used by patients with type 1 diabetes or those who have hypersensitivity reactions to this medication. Patients with impaired kidney function must adjust the dosage of this medication and take it according to the doctor’s instructions. Cold symptoms, headaches, or digestive disorders may occur while taking this medication; if symptoms are severe, consult a physician. The risk of hypoglycemia may increase when taken with other hypoglycemic agents, especially insulin or sulfonylureas, so regular blood sugar checks and dose adjustments may be necessary. If symptoms such as severe joint pain or blistering of the skin occur, discontinue use immediately and seek medical attention from a specialist. Pregnant or breastfeeding women are advised not to use this medication, and safety in children under 18 years has not been established. In older adults, renal function may decline, so regular kidney function tests before and after use are recommended, and dosage adjustments may be necessary. In case of overdose, seek immediate medical care for appropriate treatment, as this medication can be partially removed by hemodialysis. Due to potential interactions with other medications, be sure to inform healthcare providers of any medications currently being taken.

Serious side effects

Urticaria, angioedema, anaphylaxis, exfoliative skin diseases including Stevens-Johnson syndrome, acute pancreatitis, acute renal failure, severe and disabling arthralgia, bullous pemphigoid, rhabdomyolysis, rash, chest tightness, shortness of breath, cold sweat, pallor, severe rash with fever, blisters, peeling skin, pain in mouth/eyes mucosa, yellowing of skin or eyes (jaundice), extreme lethargy

Mild side effects

• Upper respiratory tract infection
• nasopharyngitis
• constipation
• vomiting
• headache
• myalgia
• limb pain
• back pain
• pruritus
• thrombocytopenia

Store this medication in a tightly sealed container to prevent air exposure, ideally at a temperature between 1 degree and 30 degrees Celsius. Proper storage will maintain the drug's efficacy and prevent degradation.

Appearance

Light beige, biconvex, round film-coated tablet

Package unit

30 tablets/box [(10 tablets/PTP) × 3]