Januglyptin Tablets 100 mg (Sitagliptin Phosphate)

Adult dose

This medication is administered as a single dose of 100 mg once daily, with a maximum daily dose of 100 mg. Patients with renal impairment may require dose adjustments. - In mild renal impairment (eGFR 60-90 mL/min/1.73 m²), no dose adjustment is needed. - In moderate renal impairment (eGFR 45-60 mL/min/1.73 m²), no dose adjustment is needed. - In moderate renal impairment (eGFR 30-45 mL/min/1.73 m²), the dose is 50 mg once daily. - In severe renal impairment (eGFR < 30 mL/min/1.73 m²) or end-stage renal disease patients requiring dialysis (eGFR < 15 mL/min/1.73 m²), the dose is 25 mg once daily. This medication can be administered regardless of dialysis timing.

This medication may cause severe allergic reactions; if symptoms such as hives or skin rash, difficulty breathing occur, take it immediately and consult a doctor. While taking this medication, symptoms of acute pancreatitis, which is inflammation of the pancreas, may occur, so alert medical personnel immediately if there are symptoms such as abdominal pain or vomiting. This medication should not be used in patients with type 1 diabetes or diabetic ketoacidosis, nor in those allergic to this drug or its components. Patients with impaired renal function need dose adjustment; hence, regular kidney function tests should be conducted, and dosage should be followed according to the physician's instructions. During treatment, side effects such as cold symptoms, headache, indigestion, and diarrhea may occur, and caution should be exercised as the risk of hypoglycemia may increase, particularly in combination with insulin or sulfonylureas. This medication can cause hypoglycemic symptoms when used with other blood sugar-lowering agents, so dosage adjustment may be needed if necessary. If severe arthralgia or blistering skin symptoms occur, notify a doctor immediately and discontinue the medication if necessary. Pregnant or breastfeeding women are advised not to take this medication, and safety and efficacy in children or adolescents under 18 years have not been established. Elderly patients may have reduced kidney function, so kidney function should be monitored before and after administration, and dosage adjustments may be required. In case of overdose, the drug should be removed from the gastrointestinal tract, and the patient's condition must be closely monitored, including electrocardiogram tests, and blood dialysis may be performed if necessary. This medication has fewer interactions with other drugs, but caution is required when combined with specific medications, so all currently administered drugs should be disclosed to the medical personnel.

Serious side effects

• Hives
• severe swelling (angioedema)
• anaphylaxis
• severe allergic reactions
• acute pancreatitis
• severe rash
• skin peeling
• oral/ocular mucosal pain
• Stevens-Johnson syndrome
• difficulty breathing

Mild side effects

• Upper respiratory infection
• nasopharyngitis
• headache
• diarrhea
• nausea
• constipation
• indigestion
• dizziness
• increased triglycerides in the blood
• gastritis

Store this medication in a tightly sealed container to prevent the ingress of air or moisture, and it should be kept at a temperature between 1 and 30 degrees Celsius. Proper storage will help maintain the medication's effectiveness for a longer period.

Appearance

Beige, round, biconvex film-coated tablet

Package unit

30 tablets/box [10 tablets/PTP x 3]