Teranubia Tablet 100 mg (Sitagliptin phosphate hydrate)

Adult dose

This medication is administered once daily at a dose of 100 mg as monotherapy or in combination therapy, with a maximum daily dose of 100 mg. It can be taken regardless of meals. In patients with renal impairment, dose adjustment is necessary for mild to moderate renal impairment (glomerular filtration rate [eGFR] 45-90 mL/min/1.73 m2), no dose adjustment is necessary. For glomerular filtration rates of 30-45 mL/min/1.73 m2, administer 50 mg once daily.

This medication may cause serious allergic reactions; therefore, if symptoms like skin rash or difficulty breathing occur within 3 months of administration, use should be discontinued immediately. There is a risk of pancreatitis, which is inflammation of the pancreas, so if abdominal pain or vomiting occurs during treatment, the doctor should be informed immediately. This medication should not be used in patients with type 1 diabetes or diabetic ketoacidosis. In patients with impaired kidney function, the dose should be adjusted and administered cautiously. Cold-like upper respiratory infections, headaches, and symptoms like rhinitis may occur during treatment. Be cautious as the risk of hypoglycemia may increase when combined with other blood sugar-lowering agents, particularly insulin or sulfonylureas. Severe joint pain or blistering conditions resembling dermatitis herpetiformis may occur, and if such symptoms arise, consult a doctor immediately. Pregnant or breastfeeding women should avoid using this medication, and safety in children or adolescents under the age of 18 has not been established. In elderly patients, kidney function may decline, so dose adjustment and kidney function monitoring are necessary. In cases of overdose, general symptomatic treatment should be conducted, and if necessary, some medications can be removed by dialysis. This medication has relatively low interactions with other drugs; however, caution may be needed when used in conjunction with certain medications, so consult a doctor or pharmacist.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, cold sweat, pallor, severe allergic reactions (anaphylaxis, angioedema, Stevens-Johnson syndrome, exfoliative skin disease), acute pancreatitis, severe skin adverse reactions (severe rash with fever, blistering, skin peeling, pain of mucous membranes in mouth/eyes), respiratory problems (difficulty breathing or shortness of breath, asthma attacks, cough with fever), liver abnormalities

Mild side effects

• Rhinitis
• upper respiratory infection
• headache
• constipation
• vomiting
• myalgia
• limb pain
• back pain
• pruritus
• thrombocytopenia

Store this medication in a tightly sealed container to protect it from air or moisture. It is recommended to maintain a storage temperature between 1 and 30 degrees Celsius to ensure the longevity of its effectiveness.

Appearance

Beige, round, biconvex film-coated tablet

Package unit

Company packaging unit