Cotonition 10/50 mg

Adult dosage

The recommended dosage is one tablet once daily, taken with water, regardless of meals. It is recommended to take it at the same time each day (e.g., in the morning). Typically, 5/50 mg of this medication is administered once daily, and if blood pressure is not adequately controlled after 2 weeks of treatment, the dose may be increased to 10/50 mg once daily.

Children's dosage

The safety and efficacy of this medication in pediatric patients under 18 years of age have not been established; thus, its use is not recommended.

This medication can cause serious harm to the fetus if taken during pregnancy, particularly in the second and third trimesters; therefore, it should be discontinued immediately upon confirmation of pregnancy. Pregnant women taking this medication should be cautious due to risks such as impaired fetal kidney function, oligohydramnios, and the potential for congenital abnormalities. Patients with reduced effective blood volume, such as those on diuretics, should stabilize their condition before taking this medication, and it may be better not to administer this medication. Patients with hypersensitivity to this medication or severe hepatic impairment, severe aortic stenosis, or in a state of shock should avoid taking it. Due to the blood pressure-lowering effect, dizziness or drowsiness may occur, so avoid driving or operating hazardous machinery. This medication should be administered cautiously to elderly patients or those with significantly impaired kidney function, as there is a risk of elevated potassium levels when combined with potassium-sparing agents. Regular monitoring of blood pressure, kidney function, and electrolyte levels during treatment is important. In case of overdose, severe hypotension and tachycardia may occur, requiring immediate medical attention. It is safest for children, pregnant women, and nursing mothers not to take this medication. Taking this medication with grapefruit juice may increase blood concentration; therefore, it is advisable to avoid this combination. While on this medication, consult healthcare professionals if taking other antihypertensives, as this may excessively enhance blood pressure-lowering effects.

Serious side effects

Rash, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, angioedema (swelling of larynx/glottis leading to airway obstruction, swelling of face/lips/pharynx/tongue), vasculitis (Henoch-Schönlein purpura), anaphylactic reaction, severe rash with high fever, blistering, peeling skin, oral/ocular mucosal pain, acute hepatitis, fulminant hepatitis, yellowing of the skin (jaundice), etc.

Mild side effects

• Dizziness
• headache
• drowsiness
• weakness
• discomfort in the chest
• chest pain
• early satiety
• peripheral edema
• pit edema
• abdominal discomfort

This medication may be sensitive to air and moisture, so it should be stored in a tightly sealed container. Additionally, it is recommended to store it at room temperature between 1 to 30 degrees Celsius, avoiding extremely hot or cold places.

Appearance

Pale pink, oblong film-coated tablet

Package unit

30 tablets/bottle