Soli-Pair Tablet 5 mg (Solenfenacin Succinate)

Adult dose

The usual recommended dose for adults (including elderly patients) is 5mg once daily. If necessary, the dose may be increased to a maximum of 10mg once daily. This medicine may be taken with or without food and should be swallowed whole with water. Dosage adjustment is required for the following patients. 1. Patients with renal impairment No dosage adjustment is necessary for patients with mild or moderate renal impairment (creatinine clearance>30ml/min). Use with caution in patients with severe renal impairment (creatinine clearance≤30ml/min), and do not exceed 5mg once daily. 2. Patients with hepatic impairment No dosage adjustment is necessary for patients with mild hepatic impairment. Use with caution in patients with moderate hepatic impairment (Child-Pugh class B), and do not exceed 5mg once daily. 3. Patients receiving potent cytochrome P450 3A4 (CYP3A4) inhibitors For patients receiving ketoconazole or another potent CYP3A4 inhibitor (e.g., ritonavir, nelfinavir, itraconazole), limit the maximum daily dose to 5mg.

This medication should not be used in patients with urinary retention or serious gastrointestinal problems such as toxic megacolon. Additionally, patients with severe myasthenia gravis or angle-closure glaucoma should not take this medication. It should also be avoided in patients with hypersensitivity to this drug or those undergoing hemodialysis, and in patients with severe liver or kidney dysfunction. Patients with certain genetic metabolic disorders should also avoid this medication. Those at risk of urinary retention or with gastrointestinal obstruction should use this medication cautiously, especially patients with poor kidney or liver function who may require dosage adjustments. Common side effects include dry mouth, constipation, blurred vision, urinary retention, and dry eyes, and if symptoms are severe, consultation with a doctor is advised. Rarely, serious allergic reactions such as angioedema or anaphylaxis may occur, so immediate treatment is required if abnormal symptoms appear. Caution is needed when driving or operating machinery due to potential drowsiness or blurred vision. Taking this medication with other anticholinergic drugs may enhance effects or exacerbate side effects, so it should be reported to a doctor before use. If taking drugs that inhibit the enzymes that metabolize this medication in the liver, the dosage should be reduced, and patients with severe kidney or liver disorders should not combine them with these medications. Pregnant women need to be cautious as the safety of this medication is not established, and breastfeeding mothers are advised to avoid this medication. Safety and efficacy in children have not been confirmed, so it should not be used in this population. In cases of overdose, appropriate emergency treatment such as administering activated charcoal is necessary instead of inducing vomiting, and professional treatment is required for severe symptoms.

• Dry mouth
• constipation
• blurred vision
• urinary retention
• dry eyes
• fecal impaction
• colonic obstruction
• intestinal obstruction
• vascular neurosis
• nausea

This medication should be stored in a tightly sealed container to protect it from air and moisture. The storage temperature should be maintained between 1 degree and 30 degrees Celsius to preserve the drug's efficacy and safety for a longer duration.

Appearance

Bright yellow, round film-coated tablets

Package unit

100 tablets (10 tablets/PTP × 10)