Donepezil Tablets 10mg (Donepezil Hydrochloride Monohydrate)

Adult dose

As donepezil hydrochloride, administer 5 mg once daily before bedtime. For 4 to 6 weeks, 5 mg is to be administered, after which the dosage may be increased to 10 mg based on clinical response. When increasing to 10 mg, monitor for gastrointestinal adverse reactions. In underweight female patients over 85 years old, the daily dose should not exceed 5 mg, requiring careful monitoring.

Child dose

There is no experience of use in children.

This medication should not be taken by individuals who are allergic to specific components. Women who are pregnant, or may become pregnant, and women who are breastfeeding should also avoid this medication. Patients with lactose intolerance or certain genetic metabolic disorders should not take this medication. Patients with heart disease or conduction disorders should use this medication with caution, as there may be a slowing of the heart rate or arrhythmias. Patients taking non-steroidal anti-inflammatory drugs or with a history of peptic ulcers should carefully monitor their gastrointestinal condition while taking this medication. Patients with a history of asthma or obstructive pulmonary disease should use this medication cautiously, as it may affect bronchial function. Patients with extrapyramidal disorders such as Parkinson's disease should be cautious, as their symptoms may worsen with this medication. This medication contains specific dyes, so individuals allergic to these components must consult a healthcare professional before use. This medication can affect the heart, leading to serious side effects such as fainting, heart block, or myocardial infarction; symptoms should be reported to a doctor immediately. Various side effects have been reported, including gastrointestinal problems such as peptic ulcers, gastrointestinal bleeding, liver function abnormalities, cerebrovascular disorders, and motor dysfunction; it is important to notify healthcare professionals if these symptoms occur during use. This medication may impact driving or machinery operation; caution is advised if experiencing fatigue, dizziness, etc. after taking. There may be interactions with other medications; it is especially important to inform healthcare professionals if taking medications metabolized by the liver or heart-related medications. It is advisable for pregnant or breastfeeding women to avoid this medication unless necessary, in which case consultation with a professional is recommended. Safety in children has not been established; therefore, this medication is not used in children. In case of overdose, serious symptoms such as vomiting, sweating, bradycardia, hypotension, and respiratory depression may occur, requiring immediate emergency treatment. This medication should be stored out of reach of children and not transferred to other containers for safety.

Serious side effects

• Fainting
• bradycardia
• heart block
• prolonged QT interval
• myocardial infarction
• heart failure
• peptic ulcers
• perforating duodenal perforation
• gastrointestinal bleeding
• hepatitis

Mild side effects

• Nausea
• vomiting
• diarrhea
• loss of appetite
• headache
• fatigue
• insomnia
• dizziness
• drowsiness
• anxiety

This medication should be stored in a tightly closed container to prevent exposure to air or moisture, at room temperature between 1°C and 30°C. Storing it this way helps maintain the medication's effectiveness and safety for use.

Appearance

Yellow round film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle