Glubia Tablet 100 mg (Sitagliptin Phosphate Hydrate)

Adult dose

The medication is administered once daily at a dose of 100 mg for monotherapy or combination therapy, with a maximum daily dose of 100 mg. This medication can be taken regardless of meals. In patients with renal impairment, dosage adjustments are needed for mild to moderate kidney impairment (estimated glomerular filtration rate [eGFR] 45-90 mL/min/1.73 m2), no dosage adjustment is required. For moderate renal impairment (eGFR 30-45 mL/min/1.73 m2), it is 50 mg.

This medication may rarely cause severe allergic reactions after administration; if symptoms such as skin rash or difficulty breathing occur, stop taking the medication immediately and consult a physician. Symptoms of pancreatitis, such as abdominal pain, vomiting, and loss of appetite may occur; if these symptoms arise, stop taking this medication immediately and visit a hospital. This medication should not be used in patients with type 1 diabetes or diabetic ketoacidosis. Patients with known allergies to this medication or its ingredients should avoid using it. Patients with reduced kidney function need to adjust the dosage of this medication, and routine kidney function tests should be conducted before and during treatment. The risk of hypoglycemia may increase when taken together with other antidiabetic agents, particularly insulin or sulfonylureas, so careful monitoring of blood sugar changes is required. This medication may cause side effects such as headache, upper respiratory infection, nasopharyngitis, diarrhea, etc.; if these symptoms are severe or persistent, consult a physician. If severe joint pain or skin blisters occur, inform a physician immediately, and if necessary, discontinue the medication. The use of this medication is not recommended for pregnant or breastfeeding women, and its safety in children under 18 has not been established. Elderly patients may require dose adjustment and kidney function tests due to the possibility of reduced kidney function. In case of overdose, go to a hospital promptly for appropriate treatment, and if necessary, blood dialysis may be possible for drug removal. The cardiovascular safety of this medication is confirmed; however, patients with pre-existing cardiovascular disease should take it according to a physician's guidance. There may be interactions with other medications, so be sure to inform your doctor or pharmacist of any medications you are currently taking.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor → severe allergic reaction, high fever with severe rash, blisters, skin peeling, oral/eye mucosal pain → severe skin reaction, breathlessness or difficulty breathing, asthma attack, cough with fever accompanied by respiratory distress → respiratory issues, yellowing of skin or eyes (jaundice), extreme lethargy → liver dysfunction (jaundice)

Mild side effects

• Nasopharyngitis
• upper respiratory infection
• headache
• constipation
• vomiting
• myalgia
• limb pain
• back pain
• pruritus
• thrombocytopenia

This medication should be stored in a sealed container to prevent air from entering and should be kept at room temperature between 1 to 30 degrees Celsius. Storing it this way helps maintain the drug's efficacy.

Appearance

Beige round, biconvex, film-coated tablet

Package unit

28 tablets/box [14 tablets/PTP*2]