Sitatin Tablet 100 mg (Sitagliptin Phosphate Hydrate)

Adult dose

This medication is administered as a single daily dose of 100 mg for monotherapy or combination therapy, with a maximum daily dose of 100 mg. This medication can be taken regardless of meals. For patients with renal impairment, dosage adjustments are necessary, and regular assessments of kidney function are recommended before and after administration. 1. For patients with mild renal impairment (glomerular filtration rate [eGFR] ≥ 60mL/min/1.73 m2 and < 90 mL/min/1.73 m2), dosage adjustment is not required. 2. For patients with moderate renal impairment (glomerular filtration rate [eGFR] ≥ 45mL/min/1.73 m2 and < 60mL/min/1.73 m2), dosage adjustment is not required. 3. For patients with moderate renal impairment (glomerular filtration rate [eGFR] ≥ 30mL/min/1.73 m2 and < 45mL/min/1.73 m2), a dose of 50 mg is administered once daily. 4. For patients with severe renal impairment (glomerular filtration rate [eGFR] ≥ 15mL/min/1.73 m2 and < 30 mL/min/1.73 m2) or end-stage renal disease requiring hemodialysis or peritoneal dialysis (glomerular filtration rate [eGFR] < 15 mL/min/1.73 m2), a dose of 25 mg is administered once daily. This medication can be administered regardless of the timing of dialysis.

This medication may cause severe allergic reactions after administration, so if symptoms like skin rash or difficulty breathing occur, it should be stopped immediately, and a doctor should be consulted. This medication may cause severe pancreatic inflammation known as pancreatitis, so if symptoms like abdominal pain, nausea, or vomiting appear, immediate medical attention should be sought. This medication should not be used in patients with type 1 diabetes or diabetic ketoacidosis, and patients with allergies to this medication or its ingredients should also not take it. Patients with reduced kidney function need to adjust the dosage of this medication, so regular kidney function tests should be conducted, and it should be taken under a doctor's guidance. Hypoglycemic symptoms may occur while taking this medication, especially when taken with insulin or sulfonylureas, which can increase the risk of hypoglycemia, so blood glucose should be checked frequently, and symptoms should be monitored. Some patients may experience side effects such as headaches, upper respiratory infections, rhinitis, diarrhea, nausea, constipation, vomiting, muscle pain, limb pain, back pain, pruritus, thrombocytopenia, dyspepsia, dizziness, increased triglycerides in the blood, increased low-density lipoproteins, hyperglycemia, weight loss, hypernatremia, and erectile dysfunction; if symptoms are severe, consultation with a doctor is advised. Pregnant or breastfeeding women are advised not to take this medication as its safety has not been established, and special care should be taken in breastfeeding as this medication can be excreted in breast milk. Elderly patients may have reduced kidney function, so kidney function should be periodically evaluated before and during the use of this medication, and dosage adjustments may be necessary. In case of overdose, immediate medical attention should be sought for appropriate treatment, as this medication can be partially removed by hemodialysis. If symptoms such as joint pain or skin blisters appear while taking this medication, the doctor should be informed immediately, and medication should be discontinued if necessary. This medication may interact with other drugs, so if other medications are being taken, it is important to inform a doctor or pharmacist, especially when taken with insulin, sulfonylureas, digoxin, and cyclosporine.

Serious side effects

Rash, severe swelling (angioedema), chest tightness, difficulty breathing, anaphylaxis, skin diseases including Stevens-Johnson syndrome, severe rashes with high fever, blisters, skin peeling, pain in mouth/eyes mucosa, acute pancreatitis, elevated liver enzymes and liver abnormalities (jaundice), severe joint pain accompanied by disability, bullous pemphigoid, acute kidney failure, rhabdomyolysis, cardiac arrest, severe headaches, seizures, loss of consciousness

Mild side effects

• Rhinitis
• upper respiratory infections
• headaches
• diarrhea
• abdominal pain
• nausea
• constipation
• vomiting
• muscle pain
• limb pain

This medication should be stored in a tightly sealed container to prevent air and moisture from entering. It is best to keep the storage temperature between 1 degree and 30 degrees Celsius at room temperature. This will help maintain the effectiveness of the medication safely.

Appearance

Beige round, biconvex film-coated tablet

Package unit

Company packaging unit