Linuvia Tablets 100 mg (Sitagliptin Phosphate Hydrate)

Adult dose

This medication is administered at a dosage of 100 mg once daily for monotherapy or combination therapy, with a maximum daily dose of 100 mg. It can be taken regardless of meals. Dosage adjustments may be necessary based on kidney function. For patients with mild to moderate renal impairment (eGFR 45 to less than 90), dosage adjustments are not required. Patients with moderate renal impairment (glomerular filtration rate between 30 and less than 45) should take 50 mg once daily.

This medication may cause serious allergic reactions in some patients. Such reactions can occur within the first 3 months after taking the medication, so if symptoms such as skin rashes, difficulty breathing, or swelling of the face or neck appear, discontinue use immediately and consult a physician. While taking this medication, acute pancreatitis may occur, so inform medical personnel immediately if symptoms such as abdominal pain, vomiting, or nausea occur. This medication should not be used by patients with type 1 diabetes or those with diabetic ketoacidosis. Additionally, it should not be taken by those who are allergic to this drug or its components. Patients with decreased kidney function may experience delayed excretion of this medication, so dosage adjustments are necessary and should be taken as directed by a physician. This medication may cause hypoglycemia when used alone or in combination with other diabetes treatments, so blood sugar levels should be carefully monitored, especially when taken with insulin or sulfonylureas. Some patients may experience severe joint pain, and if symptoms are severe or persist, medication should be discontinued and a physician consulted. Rarely, blistering skin conditions may occur, so inform medical personnel immediately if blisters or skin irritation appear. This medication generally has few drug interactions, but it is advisable to consult a physician when taking it with certain medications. It is safest for pregnant or breastfeeding women to avoid this medication, and it is not recommended for children under 18 years of age. Elderly patients should have regular kidney function tests before and after taking the medication, as kidney function may decline. In the event of overdose, general treatment and, if necessary, dialysis may be considered, so it is important to adhere to the prescribed dosage. Overall, this medication does not significantly affect cardiovascular safety, but if abnormal symptoms occur during use, consult medical personnel immediately.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, cold sweat, pallor (including severe hypersensitivity reactions such as anaphylaxis), severe rash, blisters, skin peeling, pain in oral or ocular mucosa (Stevens-Johnson syndrome and exfoliative skin diseases), acute pancreatitis (including hemorrhagic or necrotizing pancreatitis), shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities associated with cough and fever (respiratory issues), skin or eye complications

Mild side effects

• Upper respiratory infection
• nasopharyngitis
• headache
• nausea
• diarrhea
• abdominal pain
• constipation
• vomiting
• muscle pain
• limb pain

This medication should be stored in a tightly sealed container to prevent air or moisture from entering, and it is best stored at a temperature between 1 and 30 degrees Celsius at room temperature. Storing it this way helps maintain the effectiveness of the medication for a longer period.

Appearance

Beige, round, biconvex film-coated tablet

Package unit

28 tablets/box [(14 tablets/PTP×2)]