Januritin ES Tablet 100 mg (Sitagliptin Phosphate Hydrate)

Adult dose

This medication is administered once daily at a dose of 100 mg either as monotherapy or in combination therapy, with a maximum daily dose of 100 mg. It may be taken regardless of meals. For patients with renal impairment, dose adjustments are needed based on kidney function. Patients with mild to moderate renal impairment (eGFR 45 to less than 90) do not require dose adjustments. Patients with moderate renal impairment (eGFR 30 to less than 45) should take 50 mg once daily.

This medication may rarely cause severe allergic reactions after administration. If symptoms such as skin rash or difficulty breathing occur, discontinue use immediately and consult a physician. Acute pancreatitis may occur during treatment with this medication, so notify healthcare personnel immediately if symptoms such as abdominal pain, nausea, or vomiting arise. This medication should not be used in patients with type 1 diabetes or diabetic ketoacidosis, nor in patients who are allergic to this medication or its components. Patients with impaired kidney function may need dose adjustments and should undergo regular kidney function tests. This medication may be used alone or in conjunction with other diabetes treatments, but caution is advised as the risk of hypoglycemia may increase when used with insulin or sulfonylureas. During treatment, symptoms such as headache, upper respiratory infection, nasopharyngitis, dyspepsia, diarrhea, and muscle aches may occur; if these persist or worsen, consult a physician. This medication is not recommended for use in pregnant or breastfeeding women, nor in children and adolescents under 18 years old, as safety and efficacy have not been established. Due to the potential for decreased renal function in older adults, dose adjustments and monitoring of kidney function are necessary. In case of overdose, seek medical attention immediately for appropriate treatment, as some may be removed by dialysis. If skin blisters or soreness occur during treatment, consult a physician immediately for treatment, and consider stopping the medication if severe or persistent joint pain occurs. There is a possibility of drug interactions when taken with other medications, so always inform healthcare personnel about other medications being taken, especially when used with cyclosporine or digoxin, as caution is needed.

Serious side effects

Hives, severe swelling (angioedema), anaphylaxis, exfoliative skin conditions (including Stevens-Johnson syndrome), acute pancreatitis, acute kidney failure, severe hypoglycemia, blistering pemphigoid, jaundice (liver dysfunction), cardiac arrest, pneumonia, diabetes complications, metabolic acidosis, severe neurological symptoms (confusion, seizures, etc.)

Mild side effects

• Nasopharyngitis
• upper respiratory infection
• headache
• diarrhea
• dyspepsia
• nausea
• muscle pain
• limb pain
• back pain
• pruritus

This medication should be stored in a tightly closed container to prevent air and moisture from entering, at room temperature between 1 and 30 degrees Celsius. Proper storage will help maintain the drug's effectiveness and prevent degradation.

Appearance

Beige colored, round, biconvex film-coated tablet

Package unit

28 tablets/box [(14 tablets/PTPX2)]