Sitagliptin 25 mg (Sitagliptin Phosphate Hydrate)

Adult dose

This medication is administered once daily at a dose of 100 mg as monotherapy or in combination therapy, with a maximum daily dosage of 100 mg. Patients with renal impairment may require dosage adjustment based on kidney function. In patients with mild to moderate renal impairment (eGFR 45-90 mL/min/1.73 m2), dosage adjustment is not necessary. In patients with moderate renal impairment (eGFR 30-45 mL/min/1.73 m2), the dose is 50 mg once daily.

This medication is used for the treatment of diabetes, and serious allergic reactions may occur in some patients. Such allergic reactions can occur within three months of taking the medication, so caution is advised. There is a possibility of pancreatitis causing inflammation of the pancreas while taking this medication. If symptoms such as abdominal pain or vomiting occur, consult a doctor immediately. It is recommended not to use this medication in patients with type 1 diabetes or diabetic ketoacidosis. Additionally, it should be avoided by those who are allergic to this medication or its ingredients. Patients with poor kidney function need to adjust the dosage of this medication, and those undergoing dialysis should use caution. While taking this medication, side effects such as upper respiratory tract infections, headaches, dyspepsia, diarrhea, nausea, constipation, muscle pain, limb pain, back pain, itching, thrombocytopenia, dyspepsia, dizziness, increased blood triglycerides, elevated low-density lipoproteins, hyperglycemia, weight loss, hypernatremia, and erectile dysfunction may occur. In particular, the risk of hypoglycemia may increase when taken with other hypoglycemic agents such as insulin or sulfonylureas, so dosage adjustments may be necessary. Severe side effects such as severe joint pain or blistering conditions resembling bullous pemphigoid have been rarely reported; if such symptoms occur, consult a doctor immediately and discontinue use. Women who are pregnant or breastfeeding are advised not to take this medication, and it has not been established for safety and efficacy in children under 18 years of age. Elderly patients may have decreased kidney function, so kidney function tests are necessary before and during the use of this medication. In case of overdose, some of the medication may be removed through dialysis along with general treatment, so if overdose is suspected, seek medical attention immediately. This medication has relatively few drug interactions, but caution is required when taken with specific medications, so consult with a doctor or pharmacist.

Serious side effects

Hives, severe swelling (angioedema), anaphylaxis, rash, cutaneous vasculitis, exfoliative skin disorders such as Stevens-Johnson syndrome, acute pancreatitis, severe allergic reactions, acute renal failure, severe pain in the joints with disabilities, bullous pemphigoid, rhabdomyolysis

Mild side effects

• Upper respiratory infections
• nasopharyngitis
• headache
• diarrhea
• nausea
• constipation
• muscle pain
• limb pain
• back pain
• itching

This medication may be sensitive to air and moisture, so it should be stored in a tightly closed container. The storage temperature should be maintained at room temperature between 1 degree and 30 degrees Celsius. Proper storage will ensure the effectiveness of the medication.

Appearance

Pink, round, biconvex film-coated tablet

Package unit

100 tablets/box [(10 tablets/PTP × 10)]