Oxychloroquine Tablet 150 mg (Hydroxychloroquine Sulfate)

Adult dose

1. Rheumatoid arthritis, juvenile rheumatoid arthritis, discoid and systemic lupus erythematosus, and photosensitive skin diseases Adults - The initial dose is 200～400mg daily; if administering 400mg, give it in divided doses. Once an effect is achieved, reduce the dose to 200mg daily; if the effect is inadequate, increase the dose to 400mg daily. The maintenance dose should be set at the minimum effective dose and must not exceed 6.5mg/kg/day. * It may take several weeks for this drug to take effect, whereas adverse effects may occur sooner. * Discontinue treatment if there is no improvement in symptoms after 6 months of treatment for rheumatoid arthritis, juvenile rheumatoid arthritis, discoid and systemic lupus erythematosus. * For photosensitive diseases, administer only when there is substantial exposure. 2. Malaria 1) Treatment Adults - For treatment of acute disease, administer 800mg initially, followed by 400mg at 6∼8-hour intervals for 3 additional doses, for a total of 2g over 2 days. For treatment of acute disease caused by Plasmodium falciparum or P. vivax, a single dose of 800mg may be administered. 2) Prevention Adults - Administer 6mg/kg once weekly (usually 400mg weekly), starting 2 weeks before exposure.

Child dose

1. Rheumatoid arthritis, juvenile rheumatoid arthritis, discoid and systemic lupus erythematosus, and photosensitive skin diseases Children - The usual average daily dose is 200∼400mg. The maintenance dose should be set at the minimum effective dose and must not exceed 6.5mg/kg/day or the adult dose, regardless of body weight. 2. Malaria 1) Treatment Children - Administer chloroquine 10mg/kg initially, followed by 5mg/kg at 6-8-hour intervals for 3 additional doses, for a total of 25mg/kg over 2 days. However, the adult dose must not be exceeded. 2) Prevention Children - Administer 6mg/kg once weekly, starting 2 weeks before exposure. In children weighing 30～under 40kg, one tablet (200mg) exceeds an appropriate dose; therefore, administration is preferably avoided.

This medication should not be used in certain patients. For example, it should not be administered to individuals allergic to this medication or similar drugs, those with issues at the center of the eye, individuals taking other medications that may cause visual impairments, children, pregnant women, or nursing mothers. Additionally, patients sensitive to the drug or those with severe issues involving the liver, kidneys, blood, or nervous system should use this medication cautiously. Special caution is needed for those with skin diseases or certain genetic disorders. Taking this medication may cause eye issues, so regular ophthalmic exams are necessary, and if there are disturbances in vision or issues distinguishing colors, use should be immediately discontinued. Side effects of the medication may include skin rashes, hair loss, nausea, diarrhea, headaches, fatigue, mental changes, muscle weakness, blood abnormalities, cardiac rhythm issues, and liver function abnormalities, so any unusual symptoms should be promptly discussed with medical professionals. This medication may interact with other drugs, especially those related to heart issues, drugs affecting liver metabolism, and diabetes medications, so caution is advised when taken together. It is important to inform health professionals of all currently taken medications before starting this drug. Women who are pregnant or nursing should refrain from taking this medication, and special care should be taken to ensure that children are not exposed to this drug. In case of overdose, serious side effects may occur, so it is crucial to adhere strictly to the prescribed dosage, and if an overdose is suspected, seek emergency treatment immediately. Finally, this medication should be stored in a safe place out of reach of children, and transferring it from the original container to another container should be avoided.

Visual disturbances, retinal abnormalities, decreased corneal sensitivity, corneal opacities, changes in pigmentation, visual impairment, scotoma, halos, light sensitivity, skin rash, hives, changes in pigmentation of skin and mucous membranes, hair depigmentation, alopecia, vesicular rash, erythema multiforme, Stevens-Johnson syndrome, phototoxic reaction, exfoliative dermatitis, Sweet syndrome, severe skin adverse reactions, acute generalized pustular psoriasis, DRESS syndrome, nausea, diarrhea, loss of appetite, abdominal pain, upper abdominal cramps, vomiting, myasthenia, fatigue, sensorineural hearing loss, hallucinations, headache, drowsiness, restrictive neurotoxic reactions, mood changes, nightmares, tinnitus, dizziness, hearing loss, unstable mood changes, psychosis, convulsions, skeletal muscle myopathy, neuromuscular disorder, perceptual changes, decreased deep tendon reflexes, abnormal nerve conduction, aplastic anemia, agranulocytosis, leukopenia, thrombocytopenia, bone marrow suppression, QT prolongation, torsades de pointes, ventricular tachycardia, ventricular tachycardia, cardiomyopathy, biventricular hypertrophy, conduction disturbances, abnormal liver function test results, fulminant hepatic failure, hepatocellular damage, cholestatic liver injury, acute hepatitis, mixed hepatocellular/cholestatic liver injury, fulminant liver failure, depression, anxiety, agitation, confusion, delusions, mania, sleep disorders, weight loss, lethargy

This medication should be stored in a tightly closed container to protect it from air and moisture exposure. Maintaining a storage temperature between 1°C and 30°C is essential to preserving the medication's effectiveness.

Appearance

White round film-coated tablet

Package unit

30 tablets/bottle, 300 tablets/bottle