Pamaserocoxib Capsule 200 mg

Adult dose

The minimum recommended dose of this medicine should be adjusted according to the patient and may be administered with or without food. ○ Adults 1. Osteoarthritis (degenerative arthritis) Take 200 mg of celecoxib once daily, or 100 mg per dose in 2 divided doses daily. 2. Rheumatoid arthritis Take 100 mg or 200 mg of celecoxib per dose twice daily. 3. Ankylosing spondylitis (AS) Administer 200 mg of celecoxib once daily, or 100 mg per dose in 2 divided doses daily. If no effect is observed after 6 weeks, the dose may be increased to 400 mg daily. If no effect is observed after 6 weeks of treatment with 400 mg daily, another treatment method should be considered. 4. Acute pain and primary dysmenorrhea The recommended initial dose is 400 mg of celecoxib, with an additional 200 mg on the first day of treatment if necessary. From the second day of treatment, the recommended dose, if needed, is 200 mg per dose twice daily. ○ Patients with hepatic impairment In patients with moderate hepatic impairment (Child-Pugh Class II), the dose should be reduced to approximately 50% of the recommended daily dose.

This drug should be used with caution in individuals who regularly consume more than three alcoholic beverages daily due to the risk of gastrointestinal bleeding; it's essential to consult a doctor or pharmacist. There is a risk for cardiovascular issues, so serious thrombotic reactions such as heart attack or stroke may occur, and it should be used at the lowest possible dose for the shortest duration. This medication may cause serious issues such as ulcers, bleeding, or perforation in the gastrointestinal tract, so patients with a history of gastrointestinal diseases or the elderly should be particularly cautious, and if any abnormal symptoms occur, medical attention should be sought immediately. Patients allergic to this medication or those with specific diseases, pregnant or breastfeeding women, and patients with certain genetic issues should not take this drug. Patients with liver or kidney dysfunction, asthma, heart failure, hypertension, or diabetes should use this medication with caution and regularly monitor their condition under a doctor's guidance. During treatment, dizziness or drowsiness may occur, so it is advisable to avoid driving or operating machinery. This drug may interact with several other medications, so if you are taking other drugs, make sure to inform your doctor or pharmacist. Pregnant women or those planning to become pregnant should avoid this medication due to potential harm to the fetus. Caution is also required if breastfeeding. If taken for a prolonged period, regular blood tests and liver, kidney function checks should be done to monitor for abnormalities. In cases of overdose, symptoms such as nausea, vomiting, drowsiness, and abdominal pain may appear, and immediate medical attention should be sought. This medication has not established safety and efficacy in children and adolescents, so it should be avoided in those populations. The elderly may have decreased kidney and liver functions, necessitating dose adjustments and careful observation.

Gastrointestinal bleeding, cardiovascular thromboembolic reactions, myocardial infarction, stroke, perforation of the upper and lower gastrointestinal tracts, ulcers, bleeding, bronchitis, sinusitis, upper respiratory tract infections, urinary tract infections, pharyngitis, rhinitis, anemia, thrombocytopenia, hypersensitivity, insomnia, anxiety, confusion, dizziness, muscle tension, drowsiness, blurred vision, tinnitus, palpitations, congestive heart failure, arrhythmia, tachycardia, hypertension, flushing, cough, vomiting, abdominal pain, diarrhea, dyspepsia, bloating, gastric ulcers, dental disease, duodenal ulcers, esophageal ulcers, intestinal perforation, pancreatitis, elevated liver enzymes, itching, rash, urticaria, petechiae, angioedema, alopecia, vesicular dermatitis, peripheral edema, facial edema, influenza-like illness, injury, headache, leg cramps, sensory disturbance, migraine, neuralgia, neuropathy, perceptual abnormalities, cerebral infarction, aseptic meningitis, ataxia, suicidal tendencies, loss of smell, loss of taste, exacerbation of allergies, allergic reactions, weakness, chest pain, fluid retention, generalized edema, facial swelling, fatigue, lethargy, fever, facial flushing, influenza syndrome, pain, peripheral pain, sepsis, sudden death, anaphylactic-like reactions, angioedema, loss of appetite, increased appetite, depression, neuroexcitability, drowsiness, fatal intracranial hemorrhage, hallucinations, aggravated epilepsy, upper respiratory infections, sinusitis, pharyngitis, rhinitis, bronchospasm, exacerbation of bronchospasm, dyspnea, laryngitis, pneumonia, nosebleeds, voice disorders, vesicular dermatitis, dermatitis, nail disorders, photosensitivity reactions, pruritus, erythematous rash, papular rash, dry skin, increased sweating, erythema multiforme, exfoliative dermatitis, mucous membrane syndrome, toxic epidermal necrolysis, eczema, lipoma, allergic dermatitis, petechiae, dandruff, drug rash with eosinophilia and systemic symptoms, arrhythmia, left ventricular hypertrophy, angina, unstable angina, coronary artery disorders, myocardial infarction, heart failure, palpitations, tachycardia, aortic valve insufficiency, hematoma, bradycardia, syncope, ventricular fibrillation, pulmonary embolism, cerebrovascular accident, peripheral gangrene, thrombotic venous inflammation, vasculitis, deep vein thrombosis, intracerebral hemorrhage, solitary lesions, wound infection, gingivitis, herpes simplex, shingles, bacterial infections, fungal infections, soft tissue infections, viral infections, candidiasis, genital candidiasis, otitis media, breast tenderness, menopausal symptoms, fibrocystic breast disease, thoracic neoplasms, chest pain, dysmenorrhea, menstrual disorders, vaginal bleeding, vaginitis, prostate disorders, ovarian cysts, hearing loss, ear abnormalities, otalgia, hearing impairment, liver function abnormalities, elevated ALT, elevated AST, increased γ-GTP, increased ALP, positive urobilinogen, cholelithiasis, hepatitis, jaundice, liver failure, fulminant hepatitis, hepatic necrosis, elevated serum sodium, elevated serum potassium, increased BUN, increased CPK, diabetes mellitus, hypercholesterolemia, hyperglycemia, hypokalemia, hyperkalemia, increased NPN, elevated creatinine, increased alkaline phosphatase, weight gain, loss of appetite, increased LDH, hypoglycemia, hyponatremia, synovial sac, arthralgia, arthrosis, skeletal abnormalities, myalgia, cervical strain, synovitis, tendinitis, myositis, fractures, tendon rupture, back pain, muscle rigidity, decreased hematocrit, increased hemoglobin, petechiae, nosebleeds, thrombocytopenia, anemia, agranulocytosis, aplastic anemia, pancytopenia, leukopenia, granulomatous inflammation, contact dermatitis, injection site reactions, skin nodules, gustatory disturbances, albuminuria, cystitis, hematuria, dysuria, polyuria, renal stones, incontinence, urinary tract infections, visual disturbances, cataracts, conjunctivitis, eye pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, elevated serum creatinine, increased β2-microglobulin, increased NAG, positive urinary hematuria, positive urinary protein, renal dysfunction, acute renal failure, interstitial nephritis, menstrual disorders, chest pain, anaphylactic reactions, hallucinations, intracerebral hemorrhage, aseptic meningitis, loss of taste, loss of smell, vasculitis, pulmonary embolism, interstitial pneumonia, gastrointestinal bleeding, hepatitis, liver failure, fulminant hepatitis, hepatic necrosis, cholestasis, cholestatic hepatitis, jaundice, photosensitivity reactions, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, drug rash with eosinophilia and systemic symptoms, acute generalized pustular psoriasis, exfoliative dermatitis, generalized vesicular fixed drug rash, fixed drug rash, acute renal failure, hyponatremia, tubular interstitial nephritis, nephrotic syndrome, minimal change disease.

This medication should be stored in a sealed container to protect it from air and moisture. It is recommended to maintain the storage temperature between 15 degrees and 30 degrees Celsius.

Appearance

An opaque white capsule containing a white to pale yellow powder

Package unit

30 capsules/bottle, 100 capsules/bottle