Celebrex Capsule (Celecoxib)

Adult dose

The minimum recommended dose of this drug should be adjusted for each patient and may be administered with or without food. ○ Adults 1. Osteoarthritis (degenerative arthritis) Take 200 mg of celecoxib once daily, or 100 mg twice daily. 2. Rheumatoid arthritis Take 100 mg or 200 mg of celecoxib twice daily. 3. Ankylosing spondylitis (AS) Administer 200 mg of celecoxib once daily, or 100 mg twice daily. If no effect is observed after 6 weeks, the dose may be increased to 400 mg daily. If no effect is observed after 6 weeks of treatment with 400 mg daily, another treatment approach should be considered. 4. Acute pain and primary dysmenorrhea The recommended initial dose is 400 mg of celecoxib, with an additional 200 mg on the first day of treatment if needed. From the second day of treatment, the recommended dose, if needed, is 200 mg twice daily. ○ Patients with hepatic impairment For patients with moderate hepatic impairment (Child-Pugh Class II), the dose should be reduced to approximately 50% of the recommended daily dose.

This medication should be consulted with a doctor or pharmacist if taken by individuals who regularly consume three or more alcoholic beverages a day due to an increased risk of gastrointestinal bleeding. It may affect the cardiovascular system and can increase the risk of serious thrombotic events like myocardial infarction or stroke, thus it should be used at the minimum effective dosage for the shortest duration, and any cardiovascular symptoms should be reported to a doctor immediately. Serious gastrointestinal problems such as perforation, ulcer, and bleeding could occur, especially in elderly patients or those with a history of gastrointestinal disorders, who should carefully observe for gastrointestinal symptoms and seek immediate treatment for pain, dyspepsia, black stools, or hematemesis. This drug is contraindicated in individuals with certain allergies, severe liver or kidney dysfunction, active peptic ulcers, heart failure, and women who are pregnant or breastfeeding. Patients with impaired liver or kidney function, asthma, hypertension, heart failure, or diabetes should use this medication with caution, particularly older adults who are at higher risk of side effects. This medication may interact with various drugs, and if taking other medications, patients should inform their doctor or pharmacist as dosage adjustment or regular monitoring may be needed. Women who are pregnant or planning to become pregnant should avoid using this medication as it can affect the fetus, and breastfeeding women should be cautious as it may pass into breast milk. The safety and efficacy of this medication have not been established in children and adolescents under 18 years, and its use is not recommended. Dizziness or drowsiness may occur while taking this medication; therefore, caution is required when driving or operating machinery. If any adverse reactions such as rash, itching, blisters, fever, etc. occur while taking this medication, it should be discontinued immediately and a doctor consulted. Regular blood tests and liver and kidney function tests are important for long-term users to detect any abnormalities early. In case of overdose, symptoms may include nausea, vomiting, drowsiness, and lethargy, and one should seek medical attention immediately.

Gastrointestinal bleeding, cardiovascular thrombotic reactions, myocardial infarction, stroke, perforation of the upper and lower gastrointestinal tract, ulcers, bleeding, bronchitis, sinusitis, upper respiratory tract infection, urinary tract infection, pharyngitis, rhinitis, anemia, thrombocytopenia, hypersensitivity, insomnia, anxiety, confusion, dizziness, muscle rigidity, drowsiness, blurred vision, tinnitus, palpitations, congestive heart failure, arrhythmia, tachycardia, hypertension, flushing, cough, vomiting, abdominal pain, diarrhea, dyspepsia, bloating, gastric ulcer, dental disease, duodenal ulcer, esophageal ulcer, intestinal perforation, pancreatitis, elevated liver enzymes, itching, rash, hives, petechiae, angioedema, alopecia, blistering dermatitis, peripheral edema, facial swelling, influenza-like illness, injury, headache, constipation, thirst, ulcerative stomatitis, gastritis, allergy, lumbago, hyperlipidemia, diabetes, weight gain, fracture, arthralgia, positive rheumatoid factor, shingles, pneumonia, dyspnea, hearing loss, anaphylactic reaction, hallucinations, cerebral hemorrhage, aseptic meningitis, loss of taste, loss of smell, conjunctivitis, vasculitis, pulmonary embolism, interstitial pneumonia, gastrointestinal bleeding, hepatitis, liver failure, fulminant hepatitis, liver necrosis, cholestasis, cholestatic hepatitis, jaundice, photosensitivity reaction, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, drug rash with eosinophilia and systemic symptoms, acute generalized exanthematous pustulosis, exfoliative dermatitis, acute renal failure, hyponatremia, tubulointerstitial nephritis, nephrotic syndrome, focal segmental glomerulosclerosis, menstrual disorders, chest pain, elevated blood sodium, elevated blood potassium, increased BUN, increased CPK, hypercholesterolemia, hyperglycemia, hypokalemia, hyperkalemia, increased NPN, increased creatinine, increased alkaline phosphatase, weight gain, loss of appetite, increased LDH, hypoglycemia, hyponatremia, synovial cyst, arthralgia, osteoarthritis, skeletal abnormalities, myalgia, cervical dystonia, synovitis, tendonitis, myositis, leg cramps, fracture, tendon rupture, pain in the back, muscle rigidity, decreased hematocrit, increased hemoglobin, petechiae, nosebleed, thrombocytopathies, anemia, agranulocytosis, aplastic anemia, pancytopenia, leukopenia, granulomatous inflammation, contact dermatitis, injection site reactions, cutaneous nodules, taste disorders, albuminuria, cystitis, hematuria, dysuria, polyuria, kidney stones, urinary incontinence, urinary tract infection, visual blurring, cataract, conjunctivitis, eye pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, increased blood creatinine, increased β2-microglobulin, increased NAG, positive urine hematuria, positive urine protein, renal impairment, acute renal failure, interstitial nephritis

This medication should be stored in a tightly closed container to prevent air ingress, and the recommended storage temperature is between 15°C and 30°C. This will safely maintain the drug's efficacy.

Appearance

A white to off-white hard capsule filled with powder

Package unit

30 capsules/bottle, 100 capsules/bottle