Cereno Capsule 200 mg (Celecoxib)

Adult dose

The minimum recommended dose of this medicine should be adjusted according to the patient, and it may be administered with or without food. ○ Adults 1. Osteoarthritis (degenerative arthritis) Take 200 mg of celecoxib once daily, or divide the dose into 100 mg twice daily. 2. Rheumatoid arthritis Take 100 mg or 200 mg of celecoxib per dose twice daily. 3. Ankylosing spondylitis (AS) Administer 200 mg of celecoxib once daily, or divide the dose into 100 mg twice daily. If no effect is observed after 6 weeks, the dose may be increased to 400 mg daily. If no effect is observed after 6 weeks of taking 400 mg daily, another treatment should be considered. 4. Acute pain and primary dysmenorrhea The initial recommended dose is 400 mg of celecoxib, with an additional 200 mg administered on the first day if needed. From the second day of treatment, the recommended dose, if needed, is 200 mg per dose twice daily. ○ Patients with hepatic impairment For patients with moderate hepatic impairment (Child-Pugh Class II), the dose should be reduced to approximately 50% of the recommended daily dose.

This medication may pose a risk of gastrointestinal bleeding in individuals who regularly consume more than three glasses of alcohol daily, so consultation with a doctor or pharmacist is required. It may increase the risk of cardiovascular thrombotic events, myocardial infarction, and stroke, thus it should be used at the lowest effective dose for the shortest duration. Serious gastrointestinal adverse reactions such as perforation, ulcer, or bleeding may occur, so special caution is needed for the elderly or those with a history of gastrointestinal diseases. This medication should not be administered to patients with certain allergies or diseases, pregnant or breastfeeding women, or patients with severely impaired heart or kidney function. Patients with impaired liver or kidney function or a history of cardiovascular disease, hypertension, or asthma should be closely monitored and managed when using this medication. During treatment, symptoms such as dyspepsia, abdominal pain, headache, dizziness, skin rash, edema, and dyspnea may occur; if these symptoms arise, immediate consultation with healthcare professionals is advised. This medication is metabolized in the liver and may interact with other drugs, particularly those that inhibit or induce the liver metabolic enzyme CYP2C9, necessitating dose adjustments. Women who are pregnant or planning to become pregnant should avoid taking this medication, and if pregnancy is confirmed during treatment, it should be discontinued immediately. The elderly may have a higher risk of declining kidney, liver, and heart functions and require careful monitoring of dosage based on weight and condition. Dizziness or drowsiness may occur, so it is advisable to avoid driving or operating machinery. This medication does not affect platelet function and cannot replace aspirin for thrombus prevention, and there may be an increased risk of bleeding when taken with anticoagulants. Regular blood tests and monitoring of liver and kidney function are critical to check for abnormalities. In cases of overdose, symptoms such as nausea, vomiting, lethargy, and gastrointestinal bleeding may appear, requiring immediate medical attention. This medication should be kept out of reach of children, and transferring it to another container may cause degradation of quality or accidents.

Gastrointestinal bleeding, cardiovascular thrombotic reactions, myocardial infarction, stroke, perforation of the upper and lower gastrointestinal tract, ulcers, hemorrhage, bronchitis, sinusitis, upper respiratory tract infection, urinary tract infection, pharyngitis, rhinitis, anemia, thrombocytopenia, hypersensitivity, insomnia, anxiety, confusion, dizziness, muscle hypertonicity, drowsiness, blurred vision, tinnitus, palpitations, congestive heart failure, arrhythmia, tachycardia, hypertension, flushing, cough, vomiting, abdominal pain, diarrhea, dyspepsia, bloating, gastric ulcer, dental disease, duodenal ulcer, esophageal ulcer, intestinal perforation, pancreatitis, elevated liver enzymes, itching, rash, urticaria, angioedema, alopecia, bullous dermatitis, peripheral edema, facial swelling, influenza-like illness, injury, headache, leg cramps, tension, sensory depression, migraine, neuralgia, neuropathy, sensory abnormality, cerebral infarction, aseptic meningitis, ataxia, suicide, loss of smell, loss of taste, allergy exacerbation, allergic reaction, weakness, chest pain, fluid retention, generalized edema, facial edema, fatigue, lethargy, fever, facial flushing, influenza syndrome, pain, peripheral pain, sepsis, sudden death, anaphylactoid reaction, angioedema, loss of appetite, increased appetite, depression, neuroexcitation, drowsiness, fatal intracranial hemorrhage, hallucination, exacerbation of epilepsy, upper respiratory tract infection, bronchial spasm, exacerbating bronchial spasm, respiratory distress, laryngitis, pneumonia, epistaxis, voice disorder, vesicular dermatitis, dermatitis, nail disease, photosensitivity reaction, pruritus, erythematous rash, papular rash, dry skin, increased sweating, erythema multiforme, exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, eczema, lipoma, allergic dermatitis, petechiae, dandruff, drug rash with eosinophilia and systemic symptoms, arrhythmia, ventricular hypertrophy, angina pectoris, unstable angina, coronary artery disorder, heart failure, palpitations, tachycardia, aortic valve insufficiency, hematoma, sinus bradycardia, syncope, ventricular fibrillation, pulmonary embolism, cerebrovascular accident, peripheral gangrene, thrombotic venous inflammation, vasculitis, deep vein thrombosis, cerebral hemorrhage, solitary, wound infection, gingivitis, herpes simplex, herpes zoster, bacterial infection, fungal infection, soft tissue infection, viral infection, candidiasis, genital candidiasis, otitis media, breast tenderness, menopausal symptoms, fibrocystic breast disease, chest neoplasm, dysmenorrhea, menstrual disorders, vaginal bleeding, vaginitis, prostate disorder, ovarian cysts, hearing loss, ear abnormalities, ear pain, deafness, liver dysfunction, elevated ALT, elevated AST, increased γ-GTP, increased ALP, positive urobilinogen, cholelithiasis, hepatitis, jaundice, liver failure, fulminant hepatitis, liver necrosis, elevated serum sodium, elevated serum potassium, increased BUN, elevated CPK, diabetes, hypercholesterolemia, hyperglycemia, hypokalemia, hyperkalemia, increased NPN, elevated creatinine, increased alkaline phosphatase, weight gain, elevated LDH, hypoglycemia, hyponatremia, bursitis, arthralgia, osteopathy, myalgia, cervical tension, synovitis, tendinitis, myositis, fracture, tendon rupture, pain in the back, muscle rigidity, decreased hematocrit, increased hemoglobin, epistaxis, thrombocytopathy, agranulocytosis, aplastic anemia, pancytopenia, leukopenia, phlebitis, contact dermatitis, injection site reaction, skin nodules, gustatory impairment, albuminuria, cystitis, hematuria, dysuria, polyuria, kidney stones, incontinence, blurred vision, cataract, conjunctivitis, eye pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, elevated serum creatinine, increased β2-microglobulin, increased NAG, positive urine hematuria, positive urine protein, kidney dysfunction, acute renal failure, interstitial nephritis, anaphylactic reaction, hallucination, cerebral hemorrhage, aseptic meningitis, loss of taste, loss of smell, vasculitis, pulmonary embolism, interstitial pneumonia, gastrointestinal bleeding, hepatitis, photosensitivity reaction, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, drug rash with eosinophilia and systemic symptoms, acute generalized pustular exanthem, exfoliative dermatitis, acute renal failure, hyponatremia, tubulointerstitial nephritis, nephrotic syndrome, minimal change disease, menstrual disorders, chest pain, lethargy, drowsiness, nausea, upper abdominal pain, hypertension, acute renal failure, respiratory depression, coma, thirst, ulcerative stomatitis, gastritis, allergy, low back pain, hyperlipidemia, diabetes, weight gain, fracture, arthralgia, RA factor positive, herpes zoster, pneumonia, respiratory distress, elevated ALT, hearing loss

This medication should be stored in a tightly closed container to prevent entry of air or moisture. It is also advisable to keep the medication at room temperature between 15°C and 30°C. Proper storage helps maintain the effectiveness of the medication.

Appearance

A white capsule filled with a powder that is white to light yellow with yellow stripes on the top and bottom.

Package unit

30 capsules/bottle, 100 capsules/bottle