Brexivacapsule (Celecoxib)

Adult dose

The minimum recommended dose of this medicine should be adjusted for each patient and may be administered with or without food. ○ Adults 1. Osteoarthritis (degenerative arthritis) Take celecoxib 200 mg once daily or divide the dose into 100 mg twice daily. 2. Rheumatoid arthritis Take celecoxib 100 mg or 200 mg per dose twice daily. 3. Ankylosing spondylitis (AS) Administer celecoxib 200 mg once daily or divide the dose into 100 mg twice daily. If no effect is observed after 6 weeks, a dose of up to 400 mg daily may be administered. If no effect is observed after 6 weeks of treatment with 400 mg daily, another treatment method should be considered. 4. Acute pain and primary dysmenorrhea The recommended initial dose is celecoxib 400 mg, with an additional 200 mg on the first day of treatment if needed. From the second day of treatment, the recommended dose, if needed, is 200 mg per dose twice daily. ○ Patients with hepatic impairment For patients with moderate hepatic impairment (Child-Pugh Class II), the dose should be reduced to approximately 50% of the recommended daily dose.

This medication should be taken with caution by those who regularly consume more than three alcoholic drinks a day, as there is a risk of gastrointestinal bleeding; consult your doctor or pharmacist first. This medication may increase the risk of cardiovascular thrombotic events, myocardial infarction, and stroke, so it should be used at the lowest effective dose for the shortest duration while carefully monitoring for cardiovascular symptoms. This medication can cause serious gastrointestinal adverse reactions such as gastrointestinal perforation, ulcers, and bleeding; patients with a history of gastrointestinal diseases or the elderly should take extra caution, and if gastrointestinal bleeding symptoms appear, medical attention should be sought immediately. This medication should not be administered to individuals with specific allergic reactions, severe liver disorders, kidney disorders, heart failure, active peptic ulcer disease, inflammatory bowel disease, or pregnant or breastfeeding women. Patients with liver impairment, kidney impairment, asthma, hypertension, heart failure, or diabetes should use this medication with caution, and caution is also necessary when taking diuretics or ACE inhibitors. During treatment with this medication, dizziness or drowsiness may occur, so driving or operating machinery should be avoided, and regular blood tests, as well as liver and kidney function tests, should be performed to check for abnormalities. This medication can interact with multiple drugs; inform healthcare professionals if you are taking other medications, especially when used with antihypertensives, anticoagulants, antidepressants, lithium, methotrexate, and similar drugs. Women who are pregnant or planning to become pregnant should not take this medication, and if breastfeeding, they should either avoid taking it or discontinue breastfeeding. The elderly may have impaired kidney and heart function, requiring more caution and possibly dosage adjustments when using this medication. In case of overdose, symptoms may include lethargy, drowsiness, nausea, vomiting, and gastrointestinal bleeding; seek medical attention immediately for appropriate treatment. This medication should be kept out of reach of children and precautions should be taken to prevent it from being transferred to other containers.

Gastrointestinal bleeding, cardiovascular thrombotic reactions, myocardial infarction, stroke, perforation of the upper and lower gastrointestinal tract, ulcer, bleeding, bronchitis, sinusitis, upper respiratory tract infection, urinary tract infection, pharyngitis, rhinitis, anemia, thrombocytopenia, hypersensitivity, insomnia, anxiety, confusion, dizziness, muscle hypertonicity, drowsiness, blurred vision, tinnitus, palpitations, congestive heart failure, arrhythmia, tachycardia, hypertension, flushing, cough, vomiting, abdominal pain, diarrhea, indigestion, bloating, gastric ulcer, dental diseases, duodenal ulcer, esophageal ulcer, intestinal perforation, pancreatitis, elevated liver enzymes, itching, rash, urticaria, petechiae, angioedema, alopecia, vesicular dermatitis, peripheral edema, facial edema, influenza-like illness, injury, taste disorder, albuminuria, cystitis, hematuria, dysuria, polyuria, nephrolithiasis, incontinence, urinary tract infection, blurry vision, cataract, conjunctivitis, eye pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, increased serum creatinine, increased β2-microglobulin, increased NAG, positive urine hematuria, positive urine protein, impaired renal function, acute kidney injury, interstitial nephritis, increased serum sodium, increased potassium, increased BUN, increased CPK, diabetes, hypercholesterolemia, hyperglycemia, hypokalemia, hyperkalemia, increased NPN, increased creatinine, increased alkaline phosphatase, weight gain, decreased appetite, increased LDH, hypoglycemia, hyponatremia, bursitis, arthralgia, arthropathy, skeletal abnormalities, myalgia, cervical tension syndrome, synovitis, tendinitis, myositis, leg cramps, fractures, tendon rupture, pain in limbs, muscle stiffness, decreased hematocrit, increased hemoglobin, petechiae, nosebleeds, thrombocytopathy, agranulocytosis, aplastic anemia, pancytopenia, leukopenia, eczematous dermatitis, contact dermatitis, injection site reactions, skin nodules, headache, dizziness, constipation, thirst, ulcerative stomatitis, gastritis, allergy, low back pain, chest pain, hyperlipidemia, fractures, arthralgia, RA factor positive, herpes zoster, pneumonia, dyspnea, elevated ALT, hearing loss, anaphylaxis, hallucinations, cerebral hemorrhage, aseptic meningitis, loss of taste, loss of smell, vasculitis, pulmonary embolism, interstitial pneumonia, hepatitis, liver failure, fulminant hepatitis, hepatic necrosis, cholestasis, cholestatic hepatitis, jaundice, photosensitivity reaction, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, drug rash accompanied by eosinophilia and systemic symptoms, acute generalized exanthematous pustulosis, exfoliative dermatitis, acute kidney injury, hyponatremia, tubulointerstitial nephritis, nephrotic syndrome, focal segmental glomerulosclerosis, menstrual disorders, female infertility, chest pain

This medication should be stored in a tightly closed container to prevent moisture ingress and kept in a cool place between 15 and 30 degrees Celsius. Proper storage will help maintain the drug's effectiveness.

Appearance

A white capsule filled with a powder that is white to light yellow, with yellow stripes on the top and bottom.

Package unit

30 capsules/bottle, 100 capsules/bottle