Cloxib Capsule (Celecoxib)

Adult dose

The minimum recommended dose of this medicine should be adjusted for each patient, and it may be administered with or without food. Osteoarthritis (degenerative arthritis): Take celecoxib 200 mg once daily, or 100 mg twice daily in divided doses. Rheumatoid arthritis: Take celecoxib 100 mg or 200 mg twice daily. Ankylosing spondylitis (AS): Administer celecoxib 200 mg once daily, or 100 mg twice daily in divided doses. If no effect is observed after 6 weeks, the dose may be increased to 400 mg per day. If no effect is observed after 6 weeks at 400 mg per day, another treatment approach should be considered. Acute pain and primary dysmenorrhea: The initial recommended dose is celecoxib 400 mg, with an additional 200 mg on the first day of treatment if needed. From the second day of treatment, the recommended dose, if needed, is 200 mg twice daily. Patients with hepatic impairment: For patients with moderate hepatic impairment (Child-Pugh Class II), the dose should be reduced to approximately 50% of the recommended daily dose.

This medication may cause gastrointestinal bleeding in individuals who consume a lot of alcohol daily, so it's essential to consult a doctor or pharmacist. This medication can increase the risk of cardiovascular problems such as heart attack or stroke, so it should only be used at the minimum effective dose for the shortest duration. Gastrointestinal ulcers or bleeding can occur, especially in the elderly, so immediate medical attention should be sought if gastrointestinal symptoms develop. This medication should not be used in cases of specific allergies, liver or kidney disease, heart disease, or during pregnancy, and such conditions should be reported. Individuals with compromised liver or kidney function, a history of hypertension, asthma, or heart failure should use this medication with caution and require regular monitoring. This medication can interact with various drugs, so it’s important to disclose any other medications being taken. Pregnant or breastfeeding women should not use this medication, and caution is advised for those planning to become pregnant. If any unusual symptoms such as headaches, dizziness, indigestion, skin rash, or shortness of breath occur while taking this medication, immediate consultation with healthcare personnel is advised. Regular blood tests and liver and kidney function tests should be conducted in patients on long-term therapy, and the medication may be discontinued if any abnormal findings are present. It is advisable to avoid activities requiring attention, such as driving or operating machinery, while taking this medication. Children and adolescents are not recommended to use this medication as its safety and efficacy have not been established in this population. Elderly patients require special caution due to the potential for decreased liver and kidney function when taking this medication. This medication must be stored out of reach of children, and it is advisable not to transfer it to other containers.

Gastrointestinal bleeding, cardiovascular thrombotic events, myocardial infarction, stroke, perforation of the upper and lower gastrointestinal tracts, ulcers, bleeding, bronchitis, sinusitis, upper respiratory infection, urinary tract infection, pharyngitis, rhinitis, anemia, thrombocytopenia, hypersensitivity, insomnia, anxiety, delirium, dizziness, muscle tension, drowsiness, blurred vision, tinnitus, palpitations, congestive heart failure, arrhythmia, tachycardia, hypertension, flushing, cough, vomiting, abdominal pain, diarrhea, dyspepsia, bloating, gastric ulcer, dental disease, duodenal ulcer, esophageal ulcer, intestinal perforation, pancreatitis, elevated liver enzymes, itching, rash, urticaria, petechiae, angioedema, alopecia, vesicular dermatitis, peripheral edema, facial edema, influenza-like illness, damage, taste disturbance, albuminuria, cystitis, hematuria, dysuria, polyuria, nephrolithiasis, urinary incontinence, urinary tract infection, visual confusion, cataract, conjunctivitis, eye pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, increased serum creatinine, elevated β2-microglobulin, increased NAG, positive urinary hematuria, positive urinary protein, renal impairment, acute kidney injury, interstitial nephritis, headache, leg cramps, tension, sensory reduction, migraine, neuralgia, neuropathy, sensory disturbance, cerebral infarction, aseptic meningitis, ataxia, suicide, smell loss, taste loss, back pain, allergy exacerbation, allergic reaction, weakness, chest pain, fluid retention, systemic edema, facial swelling, fatigue, lethargy, fever, facial flushing, influenza-like syndrome, pain, peripheral pain, septicemia, sudden death, anaphylactic-like reaction, angioedema, loss of appetite, increased appetite, depression, neurobehavioral reaction, drowsiness, fatal intracranial hemorrhage, hallucinations, exacerbation of epilepsy, upper respiratory infection, bronchospasm, exacerbation of bronchospasm, dyspnea, laryngitis, pneumonia, epistaxis, voice disorders, vesicular dermatitis, dermatitis, nail disease, photosensitivity reaction, pruritus, erythematous rash, papular rash, skin disease, dry skin, increased sweating, erythema multiforme, exfoliative dermatitis, Sjögren's syndrome, toxic epidermal necrolysis, drug rash with eosinophilia and systemic symptoms, arrhythmia, ventricular hypertrophy, angina pectoris, unstable angina, coronary artery disease, heart failure, palpitations, tachycardia, aortic stenosis, hematoma, bradyarrhythmia, syncope, ventricular fibrillation, pulmonary embolism, cerebrovascular accident, peripheral gangrene, thrombophlebitis, vasculitis, deep vein thrombosis, cerebral hemorrhage, solitary lesion, wound infection, gingivitis, herpes simplex, herpes zoster, bacterial infection, fungal infection, soft tissue infection, viral infection, moniliasis, genital moniliasis, otitis media, breast tenderness, menopausal symptoms, fibrocystic breast disease, thoracic neoplasm, dysmenorrhea, menstrual disorders, vaginal bleeding, vaginitis, prostate disorder, ovarian cysts, hearing loss, ear abnormalities, otalgia, hearing impairment, liver dysfunction, elevated ALT, elevated AST, increased γ-GTP, increased ALP, positive urinary urobilinogen, cholelithiasis, hepatitis, jaundice, liver failure, fulminant hepatitis, hepatic necrosis, increased serum sodium, increased serum potassium, elevated BUN, increased CPK, diabetes mellitus, hypercholesterolemia, hyperglycemia, hypokalemia, hyperkalemia, increased NPN, increased creatinine, increased alkaline phosphatase, weight gain, elevated LDH, hypoglycemia, hyponatremia, synovial sac, arthralgia, arthrosis, skeletal abnormalities, myalgia, cervical tension, synovitis, tendinitis, myositis, fracture, tendon rupture, back pain, muscle rigidity, decreased hematocrit, increased hemoglobin, petechiae, epistaxis, thrombocytopathy, agranulocytosis, aplastic anemia, pancytopenia, leukopenia, pyoderma, contact dermatitis, injection site reactions, cutaneous nodules, acute kidney injury, hyponatremia, tubular interstitial nephritis, nephrotic syndrome, microangiopathic glomerulonephritis, anaphylactic reaction, hallucinations, cerebral hemorrhage, aseptic meningitis, taste loss, smell loss, vasculitis, pulmonary embolism, interstitial pneumonia, gastrointestinal bleeding, hepatitis, photosensitive reaction, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, exfoliative dermatitis, systemic vesicular fixed drug eruption, fixed drug eruption, menstrual disorders, chest pain, lethargy, drowsiness, nausea, upper abdominal pain, hypertension, acute kidney injury, respiratory depression, coma

This medication should be stored in a tightly sealed container to prevent air or moisture entry and should be kept at room temperature between 15 to 30 degrees Celsius. This will help maintain the effectiveness of the medication for a longer period.

Appearance

Capsule filled with white to light yellow powder.

Package unit

30 capsules/bottle, 100 capsules/bottle