Rexib Capsule 200 mg (Celecoxib)

Adult dose

The minimum recommended dose of this medicine should be adjusted for each patient, and it may be administered with or without food. Osteoarthritis (degenerative arthritis): Take celecoxib 200 mg once daily, or 100 mg twice daily in divided doses. Rheumatoid arthritis: Take celecoxib 100 mg or 200 mg twice daily. Ankylosing spondylitis (AS): Administer celecoxib 200 mg once daily, or 100 mg twice daily in divided doses. If no effect is observed after 6 weeks, the dose may be increased to 400 mg per day. If no effect is observed after 6 weeks at 400 mg per day, another treatment approach should be considered. Acute pain and primary dysmenorrhea: The initial recommended dose is celecoxib 400 mg, with an additional 200 mg on the first day of treatment if needed. From the second day of treatment, the recommended dose, if needed, is 200 mg twice daily. For patients with moderate hepatic impairment (Child-Pugh Class II), the dose should be reduced to approximately 50% of the recommended daily dose.

This drug should be used with caution in individuals who regularly consume more than three drinks a day, as there is a risk of gastrointestinal bleeding; consultation with a doctor or pharmacist is essential. This drug may increase the risk of cardiovascular thrombotic events, myocardial infarction, and stroke, which may lead to serious health problems. Therefore, it should be used at the lowest effective dosage for the shortest duration possible. This drug may cause serious gastrointestinal adverse reactions such as gastrointestinal perforation, ulcers, and bleeding, so particular caution is required for elderly patients or those with a history of gastrointestinal diseases. If symptoms such as epigastric pain, indigestion, black stools, or vomiting of blood occur, contact healthcare professionals immediately. This drug should not be administered to patients with specific allergic reactions, severe liver impairment, renal impairment, heart failure, active peptic ulcers, inflammatory bowel disease, pregnant women, or nursing mothers; such patients should consult with healthcare professionals. Patients with certain conditions such as liver impairment, renal impairment, asthma, hypertension, heart failure, or the elderly should use this medication cautiously and should have regular tests as directed by their healthcare provider. A variety of adverse reactions have been reported, including indigestion, headache, dizziness, hypertension, edema, skin rash, liver function abnormalities, renal function decline, etc. Immediate reporting to healthcare professionals is necessary if any abnormal symptoms occur. This drug may affect liver and kidney function; therefore, regular blood tests and liver and kidney function monitoring are needed during long-term use. This drug should not be administered to women who are pregnant or may become pregnant, as it may harm the fetus if taken during pregnancy. Nursing mothers should also avoid taking it. Safety and effectiveness have not been established for children and adolescents; therefore, it should not be used in this population. Elderly patients may have an increased risk of deterioration in renal, liver, and heart functions when taking this drug; therefore, special observation and caution are necessary. This drug may interact with other medications, so inform healthcare professionals of any other medications being taken, particularly those metabolized in the liver. Dizziness or drowsiness may occur while taking this drug; therefore, it is advisable to avoid driving or operating machinery. This drug does not affect platelet function, so it cannot be used as a substitute for aspirin in preventing cardiovascular diseases; caution is still required when combined with antiplatelet agents. In case of overdose, symptoms may include lethargy, drowsiness, nausea, vomiting, gastrointestinal bleeding, hypertension, and acute renal failure, necessitating immediate medical attention. This drug should be kept out of reach of children and should not be transferred to another container.

Gastrointestinal bleeding, cardiovascular thrombotic reactions, myocardial infarction, stroke, perforation of the upper and lower gastrointestinal tract, ulcer, bleeding, bronchitis, sinusitis, upper respiratory tract infection, urinary tract infection, pharyngitis, rhinitis, anemia, thrombocytopenia, hypersensitivity, insomnia, anxiety, confusion, dizziness, muscle rigidity, drowsiness, blurred vision, tinnitus, palpitations, congestive heart failure, arrhythmia, tachycardia, hypertension, flushing, cough, vomiting, abdominal pain, diarrhea, dyspepsia, bloating, gastric ulcer, dental disease, duodenal ulcer, esophageal ulcer, intestinal perforation, pancreatitis, elevated liver enzymes, itching, rash, urticaria, purpura, angioedema, alopecia, bullous dermatosis, peripheral edema, facial edema, influenza-like illness, injury, dysgeusia, albuminuria, cystitis, hematuria, dysuria, polyuria, kidney stones, incontinence, urinary tract infection, vision cloudiness, cataract, conjunctivitis, eye pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, elevated serum creatinine, increased β2-microglobulin, elevated NAG, positive urinary hematuria, positive urinary protein, renal dysfunction, acute kidney injury, interstitial nephritis, headache, leg cramps, hypertonia, sensory loss, migraine, neuralgia, neuropathy, sensory disturbance, cerebral infarction, aseptic meningitis, ataxia, suicide, anosmia, ageusia, back pain, exacerbation of allergies, allergic reaction, weakness, chest pain, fluid retention, systemic edema, facial swelling, fatigue, lethargy, fever, facial flushing, influenza-like syndrome, pain, peripheral pain, septicemia, sudden death, anaphylactoid reaction, angioedema, loss of appetite, increased appetite, depression, neural irritability, drowsiness, fatal intracranial hemorrhage, hallucination, exacerbation of epilepsy, upper respiratory tract infection, shingles, wound infection, gingivitis, herpes simplex, herpes zoster, bacterial infection, fungal infection, soft tissue infection, viral infection, moniliasis, genital moniliasis, otitis media, breast tenderness, menopausal symptoms, fibrocystic disease of the breast, thoracic neoplasm, chest pain, dysmenorrhea, menstrual disorders, vaginal bleeding, vaginitis, prostate disorders, ovarian cysts, hearing loss, ear abnormalities, otalgia, hearing impairment, liver dysfunction, elevated ALT, elevated AST, increased γ-GTP, elevated ALP, positive urobilinogen, cholelithiasis, hepatitis, jaundice, liver failure, fulminant hepatitis, hepatic necrosis, elevated serum sodium, elevated serum potassium, increased BUN, increased CPK, diabetes, hypercholesterolemia, hyperglycemia, hypokalemia, hyperkalemia, elevated NPN, increased creatinine, elevated alkaline phosphatase, weight gain, increased LDH, hypoglycemia, hyponatremia, bursitis, arthralgia, arthritis, skeletal deformities, myalgia, cervical dystonia, synovitis, tendinitis, myositis, fracture, tendon rupture, pain in the back, muscle stiffness, decreased hematocrit, elevated hemoglobin, epistaxis, thrombocytopathy, agranulocytosis, aplastic anemia, pancytopenia, leukopenia, granulomatous inflammation, contact dermatitis, injection site reaction, skin nodules, vision cloudiness, cataract, conjunctivitis, eye pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, acute kidney injury, hyponatremia, cholestasis, cholestatic hepatitis, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, drug rash, acute generalized exanthematous pustulosis, exfoliative dermatitis, generalized fixed drug eruption, fixed drug eruption, vasculitis, pulmonary embolism, interstitial pneumonia, menstrual disorders, chest pain, anaphylactic reaction, hallucination, cerebral hemorrhage, aseptic meningitis, loss of taste, loss of smell

This medication should be stored in a tightly sealed container to prevent air and moisture entry, preferably at room temperature between 15 to 30 degrees Celsius. This helps maintain the effectiveness of the medication for a longer period.

Appearance

A white capsule filled with white to light yellow powder with a yellow band on the top and bottom.

Package unit

30 capsules/bottle, 100 capsules/bottle