Unibrex Capsule 200 mg (Celecoxib)

Adult dose

The minimum recommended dose of this drug should be adjusted for each patient, and it may be administered with or without food. Osteoarthritis (degenerative arthritis): Take celecoxib 200 mg once daily, or divide the dose into 100 mg twice daily. Rheumatoid arthritis: Take celecoxib 100 mg or 200 mg twice daily. Ankylosing spondylitis (AS): Administer celecoxib 200 mg once daily, or divide the dose into 100 mg twice daily. If no effect is observed after 6 weeks, the dose may be increased to 400 mg per day. If no effect is observed after 6 weeks of treatment with 400 mg per day, another treatment method should be considered. Acute pain and primary dysmenorrhea: The initial recommended dose is 400 mg of celecoxib, with an additional 200 mg administered on the first day of treatment if needed. From the second day of treatment, the recommended dose as needed is 200 mg twice daily. Patients with hepatic impairment: For patients with moderate hepatic impairment (Child-Pugh Class II), the dose should be reduced to approximately 50% of the recommended daily dose.

Patients who consume large amounts of alcohol daily should consult with a doctor or pharmacist before taking this medication due to the risk of gastrointestinal bleeding. Patients with existing cardiovascular issues or risk factors may have an increased risk of cardiovascular thrombotic events, such as heart attacks or strokes, when using this medication, so caution is advised. This medication can cause serious adverse reactions such as gastrointestinal perforation, ulceration, and bleeding, so elderly patients or those with a history of gastrointestinal diseases should be particularly careful. This medication should not be administered to patients with specific allergy histories, severe liver or kidney dysfunction, active peptic ulcers, heart failure, pregnant or lactating women. Patients with compromised liver or kidney function, those at high risk for cardiovascular diseases, and patients with hypertension should use this medication with caution and require regular check-ups. This medication may interact with various other drugs, so it is essential to consult healthcare professionals if taking other medications. Pregnant women or those who may become pregnant should not use this medication as it may harm the fetus. While taking this medication, dizziness or drowsiness may occur, so it is advisable to avoid driving or operating machinery. For long-term use, regular blood tests and liver and kidney function tests should be conducted, and if any unusual symptoms arise, consult healthcare professionals immediately. This medication can cause severe skin adverse reactions; if symptoms like rash, blistering, fever, or itching appear, stop using it immediately and inform healthcare professionals. In the case of an overdose, symptoms such as lethargy, nausea, vomiting, and gastrointestinal bleeding may occur, requiring immediate emergency treatment. Keep this medication out of reach of children, and do not transfer it to another container.

Gastrointestinal bleeding, cardiovascular thrombotic reaction, myocardial infarction, stroke, perforation of the upper and lower gastrointestinal tract, ulcer, bleeding, bronchitis, sinusitis, upper respiratory tract infection, urinary tract infection, pharyngitis, rhinitis, anemia, thrombocytopenia, hypersensitivity, insomnia, anxiety, confusion, dizziness, muscle rigidity, drowsiness, blurred vision, tinnitus, palpitations, congestive heart failure, arrhythmia, tachycardia, hypertension, flushing, cough, vomiting, abdominal pain, diarrhea, dyspepsia, bloating, gastric ulcer, dental disease, duodenal ulcer, esophageal ulcer, intestinal perforation, pancreatitis, elevated liver enzymes, itching, rash, urticaria, petechiae, angioedema, alopecia, blistering dermatitis, peripheral edema, facial edema, influenza-like illness, injury, taste disturbance, albuminuria, cystitis, hematuria, dysuria, polyuria, kidney stones, incontinence, visual disturbance, cataract, conjunctivitis, eye pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, increased serum creatinine, elevated β2-microglobulin, increased NAG, positive urine hematuria, positive urine protein, renal dysfunction, acute kidney injury, epileptic nephritis, anaphylactic reaction, hallucinations, intracerebral hemorrhage, aseptic meningitis, loss of smell, conjunctivitis, vasculitis, pulmonary embolism, epileptic pneumonia, gastrointestinal bleeding, hepatitis, liver failure, fulminant hepatitis, liver necrosis, cholestasis, cholestatic hepatitis, jaundice, photosensitivity reaction, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, drug rash, acute generalized exanthematous pustulosis, exfoliative dermatitis, acute kidney injury, hyponatremia, tubulointerstitial nephritis, nephrotic syndrome, minimal change disease, menstrual disorders, chest pain, dyspepsia, abdominal pain, nausea, peripheral edema, rash, diarrhea, insomnia, headache, dizziness, constipation, gastric ulcer, urticaria, anemia, polydipsia, ulcerative stomatitis, gastritis, allergy, back pain, chest pain, hyperlipidemia, diabetes, weight gain, fracture, arthralgia, RA factor positive, shingles, pneumonia, dyspnea, elevated ALT, hearing loss, weakness, fluid retention, systemic edema, facial edema, fatigue, malaise, fever, facial flushing, influenza-like syndrome, pain, peripheral pain, sepsis, sudden death, anaphylactoid reaction, angioedema, insomnia, loss of appetite, increased appetite, depression, nervous hyperreactivity, drowsiness, fatal intracranial hemorrhage, hallucinations, exacerbation of epilepsy, upper respiratory tract infection, sinusitis, pharyngitis, rhinitis, bronchospasm, exacerbation of bronchospasm, dyspnea, laryngitis, pneumonia, epistaxis, voice disorder, vesicular dermatitis, dermatitis, nail disease, photosensitivity reaction, pruritus, erythematous rash, papular rash, skin disease, skin dryness, increased sweating, erythema multiforme, exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, eczema, lipoma, allergic dermatitis, petechiae, dandruff, drug rash associated with eosinophilia and systemic symptoms, arrhythmia, left ventricular hypertrophy, worsening hypertension, angina, unstable angina, coronary artery disease, myocardial infarction, heart failure, palpitations, tachycardia, stroke, aortic valve insufficiency, hematoma, bradycardia, syncope, ventricular fibrillation, pulmonary embolism, cerebrovascular accident, peripheral gangrene, thrombophlebitis, vasculitis, deep vein thrombosis, epileptic pneumonia, thrombocytopenia, agranulocytosis, aplastic anemia, pancytopenia, leukopenia, granulomatous inflammation, contact dermatitis, injection site reaction, skin nodule, hearing loss, abnormal ear sensation, ear pain, hearing loss, liver function abnormality, elevated ALT, elevated AST, increased γ-GTP, increased ALP, positive urinary urobilinogen, cholelithiasis, hepatitis, jaundice, liver failure, fulminant hepatitis, liver necrosis, increased serum sodium, increased serum potassium, elevated BUN, elevated CPK, hypercholesterolemia, hyperglycemia, hypokalemia, hyperkalemia, increased NPN, increased creatinine, increased alkaline phosphatase, weight gain, elevated LDH, hypoglycemia, hyponatremia, synovial cyst, arthralgia, arthritis, skeletal abnormalities, myalgia, cervical strain, synovitis, tendinitis, myositis, leg cramps, fracture, tendon rupture, back pain, muscle rigidity, decreased hematocrit, increased hemoglobin, epistaxis, thrombocytopenia, taste disturbance, albuminuria, cystitis, hematuria, dysuria, polyuria, kidney stones, incontinence, visual disturbance, cataract, conjunctivitis, eye pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, increased serum creatinine, elevated β2-microglobulin, increased NAG, positive urine hematuria, positive urine protein, renal dysfunction, acute kidney injury, epileptic nephritis

This medication should be stored in a tightly closed container to prevent air and moisture from entering. It is advisable to maintain a storage temperature between 15 and 30 degrees Celsius at room temperature. This will help ensure the medication's efficacy safely.

Appearance

Domestic: A white capsule filled with a white to light yellow powder with yellow stripes on the top and bottom. Export: A white capsule filled with a white to light yellow powder with yellow stripes on the top and bottom.

Package unit

Domestic: 30 capsules/bottle, 100 capsules/bottle Export: 100 capsules/bottle