Nizatidine Capsule 150mg (Nizatidine)

Adult dose

1. Treatment of active gastric or duodenal ulcers Adults: Administer nizatidine 300mg once daily at bedtime, or 150mg twice daily, orally in the morning and evening. Most ulcers heal within 4 weeks, but treatment may be continued for up to 8 weeks if necessary. In cases of active gastric ulcer, malignancy must be ruled out before treatment. 2. Prevention of recurrence of duodenal ulcers Adults: After healing of a duodenal ulcer, administer 150mg orally once daily at bedtime. Treatment may continue for up to 1 year; outcomes with longer-term administration are unknown. 3. Gastroesophageal reflux disease Adults: Administer 150mg orally twice daily, in the morning and evening. Treatment may continue for up to 12 weeks. 4. Improvement of gastric mucosal lesions Adults: Administer 150mg orally twice daily, in the morning and evening, for 2 weeks. 5. Dose adjustment for patients with severe renal impairment The dose for patients with renal impairment should be reduced and adjusted as follows. Creatinine clearance Dose Active duodenal ulcer Gastroesophageal reflux disease (GERD) Benign gastric ulcer 20~50 ml/min 150mg daily < 20 ml/min 150mg every other day Maintenance therapy 20~50 ml/min 150mg every other day < 20 ml/min 150mg every 3 days Some elderly patients may have a creatinine clearance below 50mL/min. Based on pharmacokinetic data in patients with renal impairment, the dose should also be reduced according to the degree of renal impairment in these patients. The clinical impact of this dose reduction in patients with renal impairment has not been evaluated.

This drug is categorized as an H2 receptor antagonist, which reduces gastric acid secretion and is used for the treatment of gastric ulcers and gastroesophageal reflux disease. Before taking this medication, do not use it if you have had an allergic reaction to this drug or similar medications. Allergic symptoms can include skin rash, itching, shortness of breath, or swelling of the throat; if these symptoms occur, stop taking the medication immediately and consult a physician. Patients with poor liver or kidney function should use this drug cautiously, and especially those with decreased kidney function should reduce the dosage or extend the dosing interval. While taking this medication, rare side effects such as anemia, changes in white blood cell count, gastrointestinal disturbances (constipation, diarrhea, nausea, etc.), liver function abnormalities, confusion, headache, drowsiness, dizziness, arrhythmias, gynecomastia, rash, sweating, and others may occur, so it is important to inform your doctor of any unusual symptoms. Because it may mask symptoms of stomach cancer, it should be used only after confirming that there is no malignant condition. If treatment is ineffective, other treatment options should be considered. Since this drug is mainly excreted through the kidneys, elderly patients or patients with reduced kidney function should undergo kidney function tests and adjust their dosage accordingly. Women who are pregnant or nursing should only take this medication after thorough consultation with a physician, as its safety during pregnancy and lactation has not been established. Safety and efficacy in pediatric patients have not been sufficiently confirmed; therefore, it should be used cautiously in children. In the case of overdose, symptoms such as vomiting, diarrhea, and miosis may occur; in such instances, seek immediate medical attention for appropriate treatment. This drug has fewer interactions with other medications, but caution is advised when taken with high-dose aspirin, as it may increase the serum salicylate concentration. During treatment, regular blood tests and monitoring of liver and kidney function should be conducted to observe any abnormalities.

• rash
• itching
• bronchial asthma
• laryngeal edema
• anaphylactic symptoms
• anemia
• leukopenia
• neutrophilia
• thrombocytopenic purpura
• constipation

This medication is sensitive to light; therefore, it should be stored in a container that does not allow light to enter. Additionally, it is recommended to store the medication at room temperature between 1 to 30 degrees Celsius, in a place that is neither too hot nor too cold.

Appearance

Capsule filled with white to off-white crystalline contents, upper part yellow, lower part light yellow

Package unit

30 capsules/bottle, 300 capsules/bottle