Diacerein Capsule 50mg (Diacerein)

Adult dose

Adults: The usual dose of diacerein is 50∼100mg daily, given orally in 1∼2 divided doses after meals. Adjust the dose as appropriate according to symptoms. For patients who have experienced loose stools or diarrhea, an initial dose of 50mg once daily is recommended for the first 2-4 weeks, followed by 50mg twice daily.

This medication should not be used in patients with inflammatory bowel disease. For example, patients with ulcerative colitis or Crohn's disease should not take this medication. Patients with intestinal obstruction syndrome or unexplained abdominal pain should also avoid using this medication. If you are allergic to this medication, its components, or Rhein-class drugs, you should not take it. It is safe not to use this medication in patients with liver disease or a history of liver disease, and in children under 15 years of age. This medication contains lactose monohydrate and should not be used in patients with lactose intolerance or certain genetic problems. Patients with a history of small intestine or colon disease should use this medication with caution, and women who are pregnant or breastfeeding, as well as elderly individuals over 65 years, should adjust the dose or take it with caution. This medication contains the dye yellow #5, thus patients allergic to this component should be cautious. During administration, gastrointestinal symptoms such as diarrhea, loose stools, or abdominal pain may occur. Special attention must be given as serious issues such as gastrointestinal bleeding, ulcers, and perforation may arise with prolonged use. Skin symptoms such as itching, rash, and eczema may commonly occur, and there may also be an increase in liver enzyme levels affecting liver function. When using this medication for a long time, it is essential to follow a doctor's instructions, and if severe diarrhea occurs, dehydration and electrolyte imbalance may occur, so you should stop taking it immediately and consult with a doctor. There is a risk of liver damage, so caution is needed when taking other medications that can burden the liver along with this one, and it is advisable to limit alcohol consumption. When taken with antacids containing calcium, magnesium, or aluminum, the absorption of this medication may be hindered, so it should be taken at least 2 hours apart. Taking it with diuretics may enhance the diuretic effect, leading to dehydration or hypokalemia, so caution is necessary. Additionally, when used with cardiac glycoside medications, the risk of arrhythmia may increase, requiring vigilance. It is preferable for pregnant or breastfeeding women not to take this medication due to reports of delayed bone formation in animal studies and the potential for some components to be transmitted through breast milk. In cases of overdose, severe diarrhea may occur, and appropriate treatment such as electrolyte replenishment is necessary.

Diarrhea, loose stools, abdominal pain, gastrointestinal disorders (bleeding, ulcers, and perforation), pigmentation of the rectal mucosa, dehydration, fluid and electrolyte imbalance, itching, rash, eczema, elevated serum liver enzymes, hypokalemia, symptoms of liver damage, severe diarrhea

This medication may be sensitive to air or moisture, so it must be stored in a tightly sealed container. It is advisable to maintain a storage temperature between 1 and 30 degrees Celsius in a cool place to preserve its efficacy for a longer period.

Appearance

A hard capsule with a yellow upper and light yellow lower part containing a brownish-yellow powder

Package unit

30 capsules/bottle, 500 capsules/bottle