Diamet Sustained-Release Tablet (Metformin Hydrochloride)

Adult dose

500 mg of Metformin Hydrochloride sustained-release tablet is administered once a day with the evening meal. Blood glucose levels should be measured a week later to adjust the dosage, and gastrointestinal adverse reactions can often be improved through gradual dosage increases. The dosage can be increased by 500 mg weekly up to a maximum of 2000 mg per day when taken with the evening meal. If blood sugar control is not achieved with a maximum dose of 2000 mg once daily, consider administering 1000 mg twice daily with meals.

This drug can rarely cause severe lactic acidosis, which can be life-threatening, so caution is required. When used with other diabetes medications, there is a risk of hypoglycemia. It should not be administered to patients with moderate to severe renal impairment, dehydration, severe infections, heart failure, acute myocardial infarction, or septic conditions that can affect renal function. If undergoing tests that use radiocontrast iodine agents, this medication should be discontinued for a period before and after the examination, and it can only be resumed once renal function is confirmed to be normal. It is not to be used in patients with allergies to this drug or similar medications, type 1 diabetes, or a history of lactic acidosis or ketoacidosis. Temporary discontinuation should occur in cases of severe infections or trauma, surgery, malnutrition, starvation, weakness, liver dysfunction, respiratory failure, and excessive alcohol consumption. It is advisable not to use this drug during pregnancy when there is a risk of placental dysfunction, preeclampsia, or intrauterine growth restriction. Caution should be taken in patients with irregular eating habits, intense exercise, or those taking interacting medications as there is a risk of lactic acidosis and hypoglycemia. During treatment with this drug, regular monitoring of renal function is required, especially for elderly patients or those with impaired renal function. Gastrointestinal symptoms (nausea, vomiting, diarrhea, etc.) may commonly occur during initial treatment but usually improve on their own. Symptoms of lactic acidosis include fatigue, muscle pain, respiratory difficulty, and abdominal pain, so if such symptoms occur, medical personnel must be notified immediately. Alcohol consumption may increase the risk of side effects from this drug, so excessive drinking should be avoided during treatment. There may be a risk of vitamin B12 deficiency, so regular monitoring of serum vitamin B12 levels is recommended. This medication can interact with other drugs, thus notifying healthcare providers about other medications being taken is necessary. Blood sugar control is extremely important during pregnancy, and if this drug is to be administered during pregnancy, fetal growth should be closely monitored. Since this drug can be secreted into breast milk, nursing mothers should consult with healthcare providers regarding whether to continue or discontinue breastfeeding. Safety in children has not been established, thus use in individuals under 17 years of age is not recommended. In the case of overdose, while hypoglycemia is rare, there is a risk of lactic acidosis; immediate medical assistance must be sought, and blood dialysis may be helpful if necessary. This tablet must be swallowed whole and should not be chewed or crushed. Keep out of reach of children and do not transfer to another container.

Serious side effects

Lactic acidosis, urticaria, severe swelling (edema), hypoglycemia, respiratory difficulty, liver dysfunction (jaundice), severe allergic reactions, risk of lactic acidosis due to renal impairment, confusion and serious neurological symptoms due to hypoglycemia

Mild side effects

• Vitamin B12 deficiency
• altered taste
• nausea
• vomiting
• diarrhea
• abdominal pain
• loss of appetite
• erythema
• itching
• urticaria

This medication should be stored in a tightly sealed container to protect it from air and moisture. Additionally, it is recommended to store it at room temperature between 1 degree and 30 degrees Celsius.

Appearance

White, double-convex, rectangular sustained-release tablet

Package unit

30 tablets/bottle, 300 tablets/bottle