Celebrex 200 mg (Celecoxib)

Adult dose

The minimum recommended dose of this medicine should be adjusted according to the patient, and it may be taken with or without food. ○ Adults: 1. Osteoarthritis (degenerative arthritis): Take celecoxib 200 mg once daily, or 100 mg twice daily. 2. Rheumatoid arthritis: Take celecoxib 100 mg or 200 mg twice daily. 3. Ankylosing spondylitis (AS): Administer celecoxib 200 mg once daily, or 100 mg twice daily. If no effect is observed after 6 weeks, the dose may be increased to 400 mg per day. If no effect is observed after 6 weeks of treatment with 400 mg per day, another treatment option should be considered. 4. Acute pain and primary dysmenorrhea: The recommended initial dose is celecoxib 400 mg, with an additional 200 mg on the first day of treatment if needed. From the second day of treatment, the recommended dose, if needed, is 200 mg twice daily. ○ Patients with hepatic impairment: For patients with moderate hepatic impairment (Child-Pugh Class II), reduce the dose to approximately 50% of the recommended daily dose.

This medication may cause a risk of gastrointestinal bleeding if taken regularly by individuals who consume more than three alcoholic drinks daily; therefore, it is essential to consult a doctor or pharmacist. Serious cardiovascular side effects such as thrombosis, myocardial infarction, and stroke may occur, so the lowest effective dose should be used for the shortest duration possible, and any cardiovascular symptoms must be reported to a healthcare provider immediately. There is a risk of gastrointestinal perforation, ulceration, and bleeding, particularly in the elderly or those with a history of gastrointestinal disorders; immediate treatment should be sought if symptoms such as epigastric pain, black stools, or hematemesis occur. Individuals with hypersensitivity to this medication or to sulfonamides, aspirin, or other nonsteroidal anti-inflammatory drugs should not take this medication, as well as those with severe liver or kidney impairment, active peptic ulcer, heart failure, pregnant or nursing women. Patients with decreased liver or kidney function, asthma, hypertension, heart failure, or diabetes should consult a doctor before taking this medication and use it with caution. During treatment, adverse reactions such as indigestion, diarrhea, headache, dizziness, hypertension, edema, and skin rashes may occur, and if symptoms are severe or persistent, a healthcare provider should be consulted. Regular blood tests, liver function, and kidney function tests should be conducted during long-term use, and if abnormal findings are noted, the medication may need to be discontinued. This medication can interact with various other drugs, so it is crucial to inform a doctor or pharmacist if taking other medications, especially blood pressure medications, anticoagulants, diuretics, and antidepressants. Women who are pregnant or planning to become pregnant should avoid this medication due to potential risks to the fetus, and nursing mothers should avoid using it or discontinue breastfeeding. The safety and efficacy in children and adolescents have not been established, so it is best not to use this medication in those age groups. The elderly are more likely to have decreased kidney, liver, and heart function, so caution is warranted during use, and those with low body weight should start with the lowest dose. Dizziness or drowsiness may occur after taking this medication; therefore, it is advisable to avoid driving or operating machinery. In case of overdose, symptoms may include nausea, vomiting, drowsiness, and gastrointestinal bleeding, and immediate medical attention should be sought. This medication should be kept out of the reach of children and should not be transferred to another container.

Gastrointestinal bleeding, cardiovascular thrombotic reactions, myocardial infarction, stroke, perforation of the upper and lower gastrointestinal tracts, ulcers, bleeding, bronchitis, sinusitis, upper respiratory tract infections, urinary tract infections, pharyngitis, rhinitis, anemia, thrombocytopenia, hypersensitivity, insomnia, anxiety, confusion, dizziness, muscle rigidity, drowsiness, blurred vision, tinnitus, palpitations, congestive heart failure, arrhythmia, tachycardia, hypertension, flushing, cough, vomiting, abdominal pain, diarrhea, dyspepsia, bloating, gastric ulcer, dental disease, duodenal ulcer, esophageal ulcer, intestinal perforation, pancreatitis, elevated liver enzymes, itching, rash, urticaria, petechial hemorrhage, angioedema, alopecia, vesicular dermatitis, peripheral edema, facial edema, influenza-like illness, injury, taste disturbances, albuminuria, cystitis, hematuria, dysuria, polyuria, kidney stones, urinary incontinence, urinary tract infection, blurred vision, cataract, conjunctivitis, eye pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, increased serum creatinine, increased β2-microglobulin, elevated NAG, positive urinary hematuria, positive urinary protein, renal dysfunction, acute renal failure, interstitial nephritis, headache, leg cramps, increased tension, sensory loss, migraine, neuralgia, neuropathy, sensory abnormalities, cerebral infarction, aseptic meningitis, ataxia, suicide, anosmia, ageusia, back pain, allergic exacerbation, allergic reaction, weakness, chest pain, fluid retention, systemic edema, facial swelling, fatigue, lethargy, fever, facial flushing, influenza-like syndrome, pain, peripheral pain, sepsis, sudden death, anaphylactic-like reactions, angioedema, insomnia, loss of appetite, increased appetite, depression, neuroexcitability, drowsiness, fatal intracranial hemorrhage, hallucinations, seizure exacerbation, upper respiratory tract infection, shingles, wound infection, gingivitis, herpes simplex, shingles, bacterial infection, fungal infection, soft tissue infection, viral infection, moniliasis, genital moniliasis, otitis media, breast tenderness, menopausal symptoms, fibrocystic disease of the breast, thoracic neoplasm, dysmenorrhea, menstrual disorders, vaginal bleeding, vaginitis, prostate disorders, ovarian cysts, hearing loss, ear abnormalities, ear pain, hearing impairment, liver dysfunction, elevated ALT, elevated AST, increased γ-GTP, elevated ALP, positive urobilinogen, cholelithiasis, hepatitis, jaundice, liver failure, fulminant hepatitis, hepatic necrosis, increased serum sodium, increased serum potassium, elevated BUN, increased CPK, diabetes mellitus, hypercholesterolemia, hyperglycemia, hypokalemia, hyperkalemia, increased NPN, elevated creatinine, increased alkaline phosphatase, weight gain, loss of appetite, increased LDH, hypoglycemia, hyponatremia, synovial sac, arthralgia, arthrosis, skeletal anomalies, myalgia, cervical tension, synovitis, tendinitis, myositis, leg cramps, fractures, tendon rupture, pain in the back, muscle stiffness, decreased hematocrit, increased hemoglobin, petechial hemorrhage, nosebleeds, thrombocytopenic purpura, anemia, thrombocytopenia, agranulocytosis, aplastic anemia, pancytopenia, leukopenia, scleritis, contact dermatitis, injection site reactions, skin nodules, blurred vision, cataract, conjunctivitis, eye pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, increased serum creatinine, increased β2-microglobulin, elevated NAG, positive urinary hematuria, positive urinary protein, renal dysfunction, acute renal failure, interstitial nephritis, anaphylactic reactions, hallucinations, cerebral hemorrhage, aseptic meningitis, loss of taste, loss of smell, conjunctivitis, vasculitis, pulmonary embolism, interstitial pneumonia, gastrointestinal bleeding, hepatitis, liver failure, fulminant hepatitis, hepatic necrosis, cholestasis, cholestatic hepatitis, jaundice, photosensitivity reactions, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, drug rash with eosinophilia and systemic symptoms, acute generalized exanthematous pustulosis, exfoliative dermatitis, acute renal failure, hyponatremia, tubular interstitial nephritis, nephrotic syndrome, minimal change disease, menstrual disorders, female infertility, chest pain, lethargy, drowsiness, nausea, upper abdominal pain, hypertension, acute renal failure, respiratory depression, coma

This medication can be sensitive to air and moisture, so it should be stored in a tightly sealed container. It is best to maintain the storage temperature between 1 and 30 degrees Celsius to preserve the effectiveness and safety of the drug over time.

Appearance

White, oval film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle