Crelorba Tablet 5 mg (Rosuvastatin Calcium)

Adult dose

Take 5 mg once daily as an initial dose, regardless of meals. If more LDL cholesterol reduction is needed, the maintenance dose can be adjusted, with most patients being maintained at 10 mg once daily. The maintenance dose should be appropriately adjusted based on LDL cholesterol levels, treatment goals, and the patient's response, with adjustments made at intervals of 4 weeks or longer.

Child dose

For pediatric patients aged 10 to 17 with heterozygous familial hypercholesterolemia, the typical dosage range is 5 mg to 20 mg once daily. The dosage should be adjusted according to each patient's treatment goals.

This medication should not be administered to certain patients. For example, it should be avoided in patients with allergies to its components, severe liver problems, muscle disorders, and those with significantly impaired kidney function. Additionally, women who are pregnant or breastfeeding, or those of childbearing potential without adequate contraception should not take this medication. This medication requires special caution in patients at high risk of muscle-related side effects, such as those with moderate or severe renal impairment, hypothyroidism, a history of genetic muscle diseases, alcohol dependence, or those using certain concomitant medications. This medication contains lactose and should not be administered to patients with lactose intolerance or associated genetic disorders. It is important to periodically monitor liver function and muscle status during treatment. Patients who consume substantial amounts of alcohol or have a history of liver disease should be observed more closely, and treatment may be discontinued if liver enzyme levels are abnormally high. If symptoms such as muscle pain, weakness, or cramps occur, immediate notification to medical personnel and further evaluation are necessary. In cases of suspected severe muscle damage, treatment should be halted, and reevaluation of re-administration should be done after recovery. This medication may interact with certain drugs, so patients should inform their healthcare providers if they are taking other medications. Particularly, the risk of muscle side effects may be increased when used in combination with certain antiviral agents, immunosuppressants, antifungals, antibiotics, and fibrate agents. It should not be used during pregnancy or breastfeeding, and women planning to conceive should use appropriate contraception. In cases of overdose, there are no specific antidotes, and treatment should be symptomatic along with monitoring liver function and muscle enzyme levels. This medication does not significantly affect the ability to drive or operate machinery; however, caution is advised due to possible dizziness. Finally, this medication may result in higher systemic levels in Asian individuals, and dosage adjustments may be necessary. It is critical to consult healthcare personnel and follow their instructions before taking the medication.

Serious side effects

Allergic reactions including urticaria and angioedema, Stevens-Johnson syndrome, drug reaction with eosinophilia and systemic symptoms (DRESS), rhabdomyolysis, severe muscle weakness, ocular myasthenia, respiratory distress, jaundice, hepatic failure, severe edema, thrombocytopenia, acute renal failure, oliguria, severe allergic reactions, severe skin reactions, respiratory problems, liver abnormalities (jaundice), severe central nervous system symptoms, severe edema.

Mild side effects

• Headache
• dizziness
• constipation
• nausea
• abdominal pain
• itching
• myalgia
• asthenia
• hematuria
• diarrhea

This medication should be stored in a tightly closed container to protect it from air and moisture. In addition, it is best to keep the medication at room temperature, between 1°C and 30°C, avoiding extreme cold or heat.

Appearance

Yellow, round, film-coated tablet

Package unit

30 tablets (10 tablets / PTP X 3)