Celebrex Capsule (Celecoxib)

Adult dose

The minimum recommended dose of this medicine should be adjusted for each patient and may be administered with or without food. ○ Adults: 1. Osteoarthritis (degenerative arthritis): Take celecoxib 200 mg once daily, or 100 mg per dose twice daily in divided doses. 2. Rheumatoid arthritis: Take celecoxib 100 mg or 200 mg per dose twice daily. 3. Ankylosing spondylitis (AS): Administer celecoxib 200 mg once daily, or 100 mg per dose twice daily in divided doses. If no effect is observed after 6 weeks, the dose may be increased to 400 mg per day. If no effect is observed after 6 weeks of treatment with 400 mg per day, other treatment options should be considered. 4. Acute pain and primary dysmenorrhea: The initial recommended dose is celecoxib 400 mg, with an additional 200 mg on the first day of treatment if needed. From the second day of treatment, the recommended dose, if needed, is 200 mg per dose twice daily. ○ Patients with hepatic impairment: For patients with moderate hepatic impairment (Child-Pugh Class II), the dose should be reduced to approximately 50% of the recommended daily dose.

This medication should be discussed with a doctor or pharmacist before taking it if the user consumes large quantities of alcohol daily. Taking it with alcohol may increase the risk of gastrointestinal bleeding. This medication may increase the risk of cardiovascular problems, such as heart attack or stroke. These risks may increase with higher doses and longer duration of use, so the lowest possible dose should be used for the shortest duration. This medication can cause gastrointestinal irritation or bleeding, so those with a history of gastrointestinal disease or gastrointestinal bleeding should be particularly cautious. Elderly individuals or those with gastrointestinal issues may be at greater risk. Individuals who are allergic to this medication or to sulfonamide drugs should not take this. Similarly, individuals with a history of allergy to aspirin or other non-steroidal anti-inflammatory drugs should also avoid its use. Patients with severely impaired liver or kidney function, those with active peptic ulcers or gastrointestinal bleeding, patients with heart or vascular diseases, and pregnant or breastfeeding women should not use this medication. Patients with mild liver or kidney dysfunction, individuals with asthma, high blood pressure, heart failure, or those taking diuretics or antihypertensive medications should use this medication with caution and be monitored regularly by a healthcare professional. This medication may cause various side effects including dyspepsia, headache, dizziness, skin rash, high blood pressure, and gastrointestinal bleeding. If unusual symptoms occur, consult a doctor immediately. Women who are pregnant or planning to become pregnant should consult a doctor before taking this medication as it may affect fertility. Additionally, breastfeeding women should avoid this medication as it may pass into breast milk and consider stopping breastfeeding or avoiding its use. This medication can interact with other drugs, so if you are taking other medications, be sure to inform your doctor or pharmacist. Caution is especially needed when taken with antihypertensive agents, diuretics, anticoagulants, antidepressants, or antibiotics. This medication has not been established as safe and effective for use in children or adolescents, so its use is not recommended. Elderly patients may have impaired kidney, liver, or heart function and should exercise extra caution when taking this medication, and dosage adjustments may be necessary. During treatment, regular blood tests and liver and kidney function tests should be performed, and if any abnormalities are detected, the medication should be stopped immediately and a doctor consulted. In the case of overdose, symptoms such as vomiting, drowsiness, lethargy, and gastrointestinal bleeding may occur, and emergency treatment is necessary. This medication should be kept out of reach of children and should not be transferred to other containers.

Gastrointestinal bleeding, cardiovascular thrombotic reactions, myocardial infarction, stroke, perforation of the upper and lower gastrointestinal tracts, ulcers, bleeding, bronchitis, sinusitis, upper respiratory tract infections, urinary tract infections, pharyngitis, rhinitis, anemia, thrombocytopenia, hypersensitivity, insomnia, anxiety, confusion, dizziness, muscle hypertonicity, drowsiness, blurred vision, tinnitus, palpitations, congestive heart failure, arrhythmia, tachycardia, hypertension, flushing, cough, vomiting, abdominal pain, diarrhea, dyspepsia, distension, gastric ulcer, dental diseases, duodenal ulcer, esophageal ulcer, intestinal perforation, pancreatitis, elevated liver enzymes, itching, rash, urticaria, petechiae, angioedema, alopecia, blistering dermatitis, peripheral edema, facial edema, influenza-like illness, injury, taste disturbance, albuminuria, cystitis, hematuria, dysuria, frequent urination, nephrolithiasis, urinary incontinence, urinary tract infection, visual disturbance, cataract, conjunctivitis, eye pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, increased serum creatinine, increased β2-microglobulin, increased NAG, positive urine hematuria, positive urine protein, renal dysfunction, acute renal failure, interstitial nephritis, increased serum sodium, increased serum potassium, increased BUN, increased CPK, diabetes mellitus, hypercholesterolemia, hyperglycemia, hypokalemia, hyperkalemia, increased NPN, increased creatinine, increased alkaline phosphatase, weight gain, loss of appetite, increased LDH, hypoglycemia, hyponatremia, bursitis, arthralgia, arthritis, skeletal abnormalities, myalgia, cervical tension, synovitis, tendinitis, myositis, leg cramps, fractures, tendon rupture, pain in the neck, muscle rigidity, decreased hematocrit, increased hemoglobin, petechiae, nosebleed, thrombocytopathy, agranulocytosis, aplastic anemia, pancytopenia, leukopenia, eosinophilic inflammation, contact dermatitis, injection site reactions, skin nodules, headache, leg cramps, tension hypertonicity, sensory decline, migraine, neuralgia, neuropathy, sensory abnormalities, cerebral infarction, aseptic meningitis, ataxia, suicidal ideation, olfactory loss, taste loss, exacerbation of allergies, allergic reactions, weakness, chest pain, fluid retention, systemic edema, facial swelling, fatigue, lethargy, fever, facial flushing, influenza-like syndrome, pain, peripheral pain, sepsis, sudden death, anaphylactoid reactions, vasculitis, pulmonary embolism, interstitial pneumonia, hepatitis, hepatic failure, fulminant hepatitis, liver necrosis, cholestasis, cholestatic hepatitis, jaundice, photosensitivity reactions, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, drug rash, acute generalized exanthematous pustulosis, exfoliative dermatitis, generalized blistering fixed drug eruption, fixed drug eruption, menstrual disorders, chest pain, anaphylaxis, hallucinations, cerebral hemorrhage, aseptic meningitis, taste loss, olfactory loss

This medication should be stored in a tightly closed container to prevent air or moisture from entering. Additionally, it is recommended to store the medication at room temperature between 15 to 30 degrees Celsius, not in excessively hot or cold environments.

Appearance

White to off-white powder filled in a white capsule

Package unit

30 capsules/bottle, 100 capsules/bottle