Hyaluronan Plus Injection (Sodium Hyaluronate) (Pre-filled)

Adult administration

Typically, for adults, administer 1 syringe once a week for 3 consecutive weeks into the knee joint or shoulder joint (shoulder joint cavity, subacromial bursa, or long head of the biceps tendon), but the number of injections should be adjusted appropriately based on symptoms.

This medication contains sodium hyaluronate and is administered via injection into the joint. It should not be used in patients who have had allergic reactions to its ingredients. Patients with a history of allergic reactions to other medications or those with liver dysfunction or a history of liver disease should use it with caution. Caution is also needed in the presence of skin disease or infection at the injection site. Though rare, this medication may cause severe allergic reactions such as shock, so symptoms should be monitored closely after use. If swelling of the face or eyes, rash, or itching occurs, use should be stopped immediately and appropriate treatment should be sought. Transient pain, swelling, redness, warmth, or pressure may occur at the injected joint site, and symptoms such as nausea, vomiting, or fever may also appear. If significant inflammation is present in the joint, it is advisable to reduce the inflammation before using this medication. After injection, it is recommended to stabilize the injection site to reduce pain. If the medication leaks outside the joint, it may cause pain, so it must be injected accurately into the joint. Aseptic conditions must be maintained during the injection, and if symptoms do not improve, the injection should be limited to three times and then stopped. If there is excess fluid in the joint, it is better to aspirate it as needed before administering this medication. This medication should not be injected directly into blood vessels or the eye, and needles of 22-23 gauge are recommended for use. Care should be taken as the medication may precipitate when used with specific disinfectants. Women who are pregnant or may become pregnant should use this medication cautiously only if the therapeutic effect is judged to outweigh the risks. Additionally, as this medication can be passed through breast milk, it is advisable to avoid breastfeeding during treatment. Safety in pediatric patients has not been confirmed, so it should only be used cautiously when necessary. Elderly patients may have diminished physical functions, so caution is advised during use.

Serious side effects

Shock symptoms (severe allergic reaction)

Mild side effects

• Edema (facial, eyelid, etc.)
• facial flushing
• rash
• urticaria
• itching
• pain
• swelling
• redness
• warmth
• severe local pressure

This medication should be stored in a sealed container to prevent air and moisture from entering. The storage temperature is recommended to be at room temperature between 1 to 30 degrees Celsius.

Appearance

A colorless, transparent, viscous liquid contained in a glass vial sealed with rubber stoppers at both ends (part of the pre-filled syringe system).

Package unit

2 milliliters/pre-filled syringe [× 3]