Alzepil Tablets 5 mg (Donepezil Hydrochloride Monohydrate)

Adult dose

Adults: Administer donepezil hydrochloride 5 mg once daily before bedtime. If sleep disturbances such as unusual dreams, nightmares, or insomnia occur, morning administration of this drug may be considered. Since donepezil concentrations reach steady state after 15 days of administration and the frequency of adverse reactions may be affected by the rate of dose increase, administer the 5 mg dose for 4~6 weeks. After evaluating the clinical response during this period, the dose may be increased to 10 mg. When increasing the dose to 10 mg once daily, administer with caution regarding gastrointestinal adverse reactions. If treatment with this drug is stopped, its effects gradually decrease, and no rebound effect occurs with abrupt discontinuation. Women aged 85 years and older with low body weight: Careful monitoring is necessary because adverse reactions occur more frequently. Elderly women with low body weight should not exceed 5 mg once daily.

Child dose

Children: There is no experience with use in children.

This medication contains the ingredient Donepezil Hydrochloride and is mainly used for the treatment of Alzheimer-type dementia symptoms. Firstly, this medication should not be used in certain patients. For example, individuals with an allergy to this medication or its ingredients, pregnant women or those who may become pregnant, and individuals with lactose intolerance or certain genetic metabolic disorders should not take this medication. Moreover, individuals with heart diseases or problems with heart rhythm should use this medication cautiously, as it can slow down heart rate or cause arrhythmia. Patients with a history of peptic ulcers or those taking non-steroidal anti-inflammatory drugs should also be cautious. This medication can stimulate gastric acid secretion, which may worsen peptic ulcer symptoms. Individuals with asthma or obstructive pulmonary disease should also be cautious when taking this medication, as it may cause bronchoconstriction or increase bronchial secretions, worsening their symptoms. Patients with extrapyramidal disorders such as Parkinson's disease may also experience worsening symptoms when using this medication. During the use of this medication, various side effects may occur. Common side effects include nausea, vomiting, diarrhea, dizziness, insomnia, and decreased appetite, while rarely severe heart issues, liver function abnormalities, cerebrovascular disorders, and muscle symptom abnormalities have been reported. As a cholinesterase inhibitor, this medication may slow heart rate; therefore, patients with heart disease or electrolyte imbalance should take particular care and may need to undergo electrocardiogram testing if necessary. Caution is also necessary when driving or operating machinery. The use of this medication may cause fatigue, dizziness, muscle cramps, etc., which can affect safety. It is advisable for women who are pregnant or breastfeeding to avoid using this medication, and if necessary, to consult a specialist. This medication may interact with other drugs, so it is essential to follow the doctor's instructions, especially when used in combination with antibiotics, antidepressants, antiarrhythmics, antipsychotics, and certain pain medications. In case of overdose, serious symptoms such as nausea, vomiting, bradycardia, respiratory depression, and seizures may occur, necessitating an immediate visit to a medical facility, where atropine may be used as an antidote. Finally, this medication should be kept out of the reach of children, and transferring it to other containers should be avoided.

• Syncope
• bradycardia
• heart block
• prolonged QT interval
• myocardial infarction
• heart failure
• peptic ulcer
• perforated duodenal perforation
• gastrointestinal bleeding
• hepatitis

This medication should be stored in a tightly sealed container to prevent air or moisture from entering. It is recommended to maintain a storage temperature between 1 degree and 30 degrees Celsius. This will help preserve the medication's effectiveness over time.

Appearance

White round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle