Tocilizumab Capsule 200 mg (Celecoxib)

Adult dose

The minimum recommended dose of this medicine should be adjusted for each patient and may be administered with or without food. Osteoarthritis (degenerative arthritis): Administer celecoxib 200 mg once daily or divide the dose into 100 mg twice daily. Rheumatoid arthritis: Administer celecoxib 100 mg or 200 mg per dose, twice daily. Ankylosing spondylitis (AS): Administer celecoxib 200 mg once daily or divide the dose into 100 mg twice daily. If no effect is observed after 6 weeks, the dose may be increased to 400 mg per day. If no effect is observed after 6 weeks at 400 mg per day, another treatment option should be considered. Acute pain and primary dysmenorrhea: The recommended initial dose is celecoxib 400 mg, with an additional 200 mg on the first day if needed. From the second day of treatment, the recommended dose, if needed, is 200 mg per dose, twice daily. In patients with moderate hepatic impairment (Child-Pugh Class II), the dose should be reduced to approximately 50% of the recommended daily dose.

This medication should be used with caution by individuals who regularly consume more than three drinks a day, as it may increase the risk of gastrointestinal bleeding; consultation with a doctor or pharmacist is essential. Individuals with cardiovascular issues may have an increased risk of serious thrombotic events such as myocardial infarction or stroke when taking this medication, thus it should be used at the lowest effective dose for the shortest duration possible. This medication can cause gastric ulcers or bleeding; therefore, elderly patients or those with a history of gastrointestinal disorders should monitor for gastrointestinal symptoms while taking this and consult a doctor. Patients who are allergic to this medication or have specific liver or kidney diseases, pregnant or breastfeeding women, and those with certain heart conditions should not take this medication. Patients with compromised liver or kidney function, or a history of asthma, hypertension, or congestive heart failure must exercise additional caution when using this medication and regular monitoring is necessary. Possible side effects include headache, dyspepsia, skin rashes, edema, elevation of blood pressure, etc.; if severe symptoms occur, immediate consultation with a doctor is advised. This medication may interact with several other drugs; therefore, it is important to notify healthcare providers about other medications being taken, particularly blood pressure medications, anticoagulants, antidepressants, lithium, and methotrexate. Pregnant women or those planning to become pregnant should avoid use as this medication may affect reproductive capacity, and breastfeeding women should consult a doctor as it may be excreted in breast milk. Safety and efficacy have not been established in individuals under 18 years of age, so it is advised not to use this medication in this population. Elderly patients should be particularly cautious due to the higher likelihood of impaired kidney and liver functions; a lower starting dose is advisable in those with low body weight. For long-term use, regular blood tests and assessment of liver and kidney function are necessary to detect any abnormalities, and if any are found, discontinuation of the medication is required. In case of overdose, symptoms such as vomiting, drowsiness, abdominal pain, etc., may arise, requiring immediate medical treatment; while no specific antidote exists, supportive treatment may aid in recovery. This medication should be kept out of reach of children and care should be taken to avoid transferring it to other containers to prevent accidental ingestion and quality issues.

Gastrointestinal bleeding, cardiovascular thromboembolic events, myocardial infarction, stroke, perforation of the upper and lower gastrointestinal tract, ulcers, bleeding, bronchitis, sinusitis, upper respiratory tract infections, urinary tract infections, pharyngitis, rhinitis, anemia, thrombocytopenia, hypersensitivity, insomnia, anxiety, confusional state, dizziness, muscle hypertonia, drowsiness, blurred vision, tinnitus, palpitations, congestive heart failure, arrhythmia, tachycardia, hypertension, flushing, cough, vomiting, abdominal pain, diarrhea, dyspepsia, bloating, gastric ulcer, dental disease, duodenal ulcer, esophageal ulcer, intestinal perforation, pancreatitis, elevated liver enzymes, itching, rash, urticaria, petechiae, angioedema, alopecia, bullous dermatitis, peripheral edema, facial edema, influenza-like illness, injury, taste disturbance, albuminuria, cystitis, hematuria, dysuria, polyuria, kidney stones, urinary incontinence, urinary tract infection, visual disturbance, cataract, conjunctivitis, eye pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, increased serum creatinine, elevated β2-microglobulin, increased NAG, positive urinary hema, positive urinary protein, renal dysfunction, acute renal failure, interstitial nephritis, headache, leg cramps, hypertonicity, decreased sensation, migraine, neuralgia, neuropathy, sensory abnormalities, cerebral infarction, aseptic meningitis, ataxia, suicidal thoughts, anosmia, ageusia, exacerbation of allergies, allergic reaction, weakness, chest pain, fluid retention, generalized edema, facial edema, fatigue, lethargy, fever, facial flushing, influenza-like syndrome, pain, peripheral pain, sepsis, sudden death, anaphylactoid reaction, vasculitis, pulmonary embolism, interstitial pneumonia, hepatitis, liver failure, fulminant hepatitis, liver necrosis, cholestasis, cholestatic hepatitis, jaundice, photosensitive reaction, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, drug rash associated with eosinophilia and systemic symptoms, acute generalized exanthematous pustulosis, exfoliative dermatitis, fixed drug eruption, fixed drug rash, menstrual disorders, female infertility, chest pain, anaphylactic reaction, hallucination, vasculitis, pulmonary embolism, gastrointestinal bleeding, hepatitis, acute renal failure, hyponatremia, tubulointerstitial nephritis, nephrotic syndrome, minimal change disease, hearing loss, ear abnormalities, otalgia, hearing impairment, cholelithiasis, hepatitis, jaundice, liver failure, fulminant hepatitis, liver necrosis, cholestasis, cholestatic hepatitis, thrombocytopathy, agranulocytosis, aplastic anemia, pancytopenia, leukopenia, interstitial nephritis, contact dermatitis, injection site reaction, skin papules, increased serum sodium, increased serum potassium, elevated BUN, increased CPK, diabetes, hypercholesterolemia, hyperglycemia, hypokalemia, hyperkalemia, increased NPN, increased creatinine, elevated alkaline phosphatase, weight gain, anorexia, increased LDH, hypoglycemia, hyponatremia, bursitis, arthralgia, arthropathy, skeletal abnormalities, myalgia, cervical dystonia, synovitis, tendinitis, myositis, leg cramps, fractures, tendon rupture, pain in the back, muscle rigidity, decreased hematocrit, increased hemoglobin, epistaxis, thrombocytopenia, agranulocytosis, aplastic anemia, pancytopenia, leukopenia, injury, chest pain, polydipsia, ulcerative stomatitis, gastritis, allergy, low back pain, hyperlipidemia, diabetes, weight gain, fractures, arthralgia, positive RA factor, herpes zoster, pneumonia, dyspnea, elevated ALT, hearing impairment

This medication should be stored in an airtight container to protect it from air and moisture, and kept in a cool place between 15 and 30 degrees Celsius. Proper storage helps in maintaining the drug's efficacy and prevents degradation.

Appearance

A hard capsule with a white opaque body and yellow cap with a filling of white to light yellow powder.

Package unit

30 capsules/bottle