Cybrelax Capsule 200 mg (Celecoxib)

Adult dose

The minimum recommended dose of this medicine should be adjusted according to the patient, and it may be administered regardless of meals. ○ Adults: 1. Osteoarthritis (degenerative arthritis): Take 200 mg of celecoxib once daily, or 100 mg twice daily. 2. Rheumatoid arthritis: Take 100 mg or 200 mg of celecoxib twice daily. 3. Ankylosing spondylitis (AS): Administer 200 mg of celecoxib once daily, or 100 mg twice daily. If no effect is observed after 6 weeks, the dose may be increased to 400 mg daily. If no effect is observed after 6 weeks of treatment at 400 mg daily, another treatment option should be considered. 4. Acute pain and primary dysmenorrhea: The initial recommended dose is 400 mg of celecoxib, with an additional 200 mg administered on the first day of treatment if needed. From the second day of treatment, the recommended dose, if needed, is 200 mg twice daily. ○ Patients with hepatic impairment: For patients with moderate hepatic impairment (Child-Pugh Class II), the dose should be reduced to approximately 50% of the recommended daily dose.

This medication can cause gastrointestinal bleeding if taken by individuals who regularly consume more than three alcoholic drinks a day, therefore, it is essential to consult with a doctor or pharmacist. This medication may increase the risk of serious cardiovascular issues, such as cardiovascular thrombotic events, myocardial infarction, and stroke, so it should be used at the lowest effective dose for the shortest duration, and medical consultation should be sought immediately if cardiovascular symptoms occur. There is a risk of perforation, ulcers, and bleeding in the upper and lower gastrointestinal tract, so special caution should be exercised, especially in the elderly or those with a history of gastrointestinal diseases. This medication should not be administered to individuals with a sulfonamide allergy, those with a history of allergic reactions to aspirin or other non-steroidal anti-inflammatory drugs, individuals with severe liver or kidney impairment, those with active peptic ulcers or inflammatory bowel disease, individuals with a history of cardiovascular diseases, or pregnant or nursing women. Patients with liver or kidney issues, asthma, heart failure, hypertension, edema, the elderly, or diabetes should take special care when using this medication and may require regular monitoring. This medication can cause various adverse reactions. Common symptoms include dyspepsia, diarrhea, abdominal pain, dizziness, drowsiness, hypertension, rash, etc. In severe cases, skin rashes, liver dysfunction, kidney function decline, and cardiovascular adverse reactions may occur, so it is necessary to consult a doctor immediately if symptoms arise. This medication is metabolized by certain enzymes in the liver, which may lead to interactions with other drugs. It is vital to inform the healthcare provider of any other medications being taken, particularly antihypertensives, anticoagulants, antidepressants, and antibiotics when using this drug. Women who are pregnant or of childbearing potential should refrain from taking this medication, and it is also advisable to avoid it while nursing. The safety and efficacy in children and adolescents have not been established, so its use is not recommended. Elderly patients may have reduced liver and kidney function, requiring special attention when taking this medication, and dosage adjustments may be necessary. Patients who take this medication for an extended period should have regular blood tests and liver and kidney function tests, and should consult a doctor immediately if any abnormal findings occur. In cases of overdose, symptoms such as lethargy, drowsiness, nausea, vomiting, and gastrointestinal bleeding may appear, and immediate medical attention is necessary. This medication should be kept out of reach of children and should not be transferred to other containers as a safety measure.

Gastrointestinal bleeding, cardiovascular thrombotic reactions, myocardial infarction, stroke, perforation of the upper and lower gastrointestinal tract, ulcers, bleeding, bronchitis, sinusitis, upper respiratory tract infections, urinary tract infections, pharyngitis, rhinitis, anemia, thrombocytopenia, hypersensitivity, insomnia, anxiety, delirium, dizziness, muscle hypertonia, drowsiness, blurred vision, tinnitus, palpitations, congestive heart failure, arrhythmia, tachycardia, hypertension, flushing, cough, vomiting, abdominal pain, diarrhea, dyspepsia, bloating, gastric ulcers, dental disorders, duodenal ulcers, esophageal ulcers, intestinal perforation, pancreatitis, elevated liver enzymes, itching, rash, urticaria, petechiae, angioedema, alopecia, blistering dermatitis, peripheral edema, facial swelling, influenza-like illness, injury, taste disturbance, albuminuria, cystitis, hematuria, dysuria, polyuria, kidney stones, urinary incontinence, urinary tract infections, visual haze, cataracts, conjunctivitis, eye pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, increased serum creatinine, elevated β2-microglobulin, increased NAG, positive urine hematuria, positive urine protein, renal dysfunction, acute renal failure, interstitial nephritis, elevated serum sodium, elevated serum potassium, increased BUN, increased CPK, diabetes, hypercholesterolemia, hyperglycemia, hypokalemia, hyperkalemia, increased NPN, increased creatinine, increased alkaline phosphatase, weight gain, loss of appetite, increased LDH, hypoglycemia, hyponatremia, synovial sac, arthralgia, arthritis, skeletal abnormalities, myalgia, cervical tension syndrome, synovitis, tendinitis, myositis, leg cramps, fractures, tendon rupture, pain in the back, muscle rigidity, decreased hematocrit, increased hemoglobin, petechiae, nosebleeds, thrombocytopathy, agranulocytosis, aplastic anemia, pancytopenia, leukopenia, angioedema, contact dermatitis, injection site reactions, skin nodules, headache, dizziness, constipation, thirst, ulcerative stomatitis, gastritis, allergies, back pain, chest pain, hyperlipidemia, weight gain, fractures, arthralgia, positive RA factor, herpes zoster, pneumonia, dyspnea, elevated ALT, hearing loss, anaphylactic reactions, hallucinations, cerebral hemorrhage, aseptic meningitis, loss of taste, loss of smell, pulmonary embolism, interstitial pneumonia, hepatitis, liver failure, fulminant hepatitis, hepatic necrosis, cholestasis, cholestatic hepatitis, jaundice, photosensitivity reactions, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, drug rash accompanied by eosinophilia and systemic symptoms, acute generalized exanthematous pustulosis, desquamative dermatitis, fixed drug eruption, acute renal failure, hyponatremia, tubular interstitial nephritis, nephrotic syndrome, minor lesion focal segmental glomerulosclerosis, menstrual disorders, female infertility, chest pain

This medication should be stored in a tightly closed container to prevent moisture exposure and kept at room temperature between 15 to 30 degrees Celsius. Proper storage will help maintain the medication's effectiveness and safety.

Appearance

A capsule filled with white to pale yellow powder, with a white upper and lower shell.

Package unit

30 capsules/bottle, 100 capsules/bottle