Neupezil Buccal Disintegrating Film 10 mg (Donepezil Hydrochloride)

Adult dose

As Donepezil Hydrochloride, administer 5 mg once daily before bedtime. For 4-6 weeks, the 5 mg dosage should be maintained, and after assessing the clinical response, it may be increased to 10 mg. When increasing to 10 mg once daily, attention should be paid to gastrointestinal adverse reactions. This medication can be taken as a buccal disintegrating film placed on the tongue to dissolve without water.

Child dose

There is no experience with the use in pediatric patients.

This medication contains Donepezil Hydrochloride and is used for the treatment of Alzheimer's dementia. This medication should not be used in individuals who are allergic to Donepezil Hydrochloride or any other component of this medication, women who are pregnant or may become pregnant, and women who are breastfeeding. Patients with heart disease or cardiac conduction disorders should be cautious as this medication may slow heart rate or cause arrhythmias. Patients taking non-steroidal anti-inflammatory drugs or with a history of peptic ulcers should be careful as this medication may stimulate gastric acid secretion, worsening ulcer symptoms. Patients with asthma or obstructive pulmonary disease should be cautious as this medication may induce bronchoconstriction and worsen symptoms. Patients with extrapyramidal disorders such as Parkinson's disease may experience worsening of symptoms due to this medication, so caution is necessary. Severe side effects reported during the use of this medication include syncope, cardiac issues, gastrointestinal bleeding, liver dysfunction, cerebrovascular disorders, movement disorders, severe muscle atypical reactions, respiratory distress, acute pancreatitis, acute renal failure, and unexplained sudden death. Common side effects may include nausea, vomiting, diarrhea, dizziness, insomnia, headaches, fatigue, anxiety, hallucinations, changes in heart rate, etc. This medication is not approved for other types of dementia or memory disorders outside of Alzheimer's dementia, and treatment should be conducted under the supervision of an experienced physician. Patients with cardiovascular disease should regularly monitor their heart rate and conduction status, and those with a history of gastrointestinal diseases should be vigilant for gastrointestinal symptoms. This medication may affect driving or operating machinery, so caution is necessary during the initial administration or when changing doses. Pregnant or breastfeeding women are advised not to use this medication, and if necessary, they should consult a professional before proceeding with caution. This medication can interact with other drugs, especially when taken with heart-related medications, antibiotics, antidepressants, antipsychotics, and non-steroidal anti-inflammatory drugs, so caution is needed. In case of overdose, symptoms such as nausea, vomiting, sweating, bradycardia, hypotension, respiratory depression, and muscle weakness may occur, requiring immediate medical attention. This medication is available in buccal disintegrating film form and should be placed in the mouth to dissolve without water; it should be stored out of reach of children and shielded from direct sunlight.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, pain in oral/ocular mucosa, difficulty in breathing, asthma attack, respiratory distress accompanied by cough and fever, jaundice (yellowing of skin or eyes), extreme lethargy, sudden and severe headaches, thunderclap headaches, seizures, confusion, vision changes, paralysis, urination.

Mild side effects

• Nausea
• vomiting
• diarrhea
• decreased appetite
• headaches
• dizziness
• insomnia
• drowsiness
• myalgia
• fatigue

This medication should be stored in a tightly closed container to avoid exposure to air, moisture, and light. The storage temperature should be maintained between 1°C and 30°C room temperature. Proper storage helps retain the medication's effectiveness.

Appearance

Pale yellow rectangular buccal disintegrating film

Package unit

30 films (1 film/pack X 30)/box