ESO Tablet 40 mg (Esomeprazole Magnesium Trihydrate)

Adult dosage

This medication must be swallowed with liquids such as water and should not be chewed or crushed. 1) Gastroesophageal reflux disease (GERD) - Treatment of erosive esophagitis: 40 mg once daily for 4 weeks - If esophagitis is not treated or symptoms continue, take for an additional 4 weeks. - Long-term maintenance therapy for prevention of recurrence in patients with esophagitis: 20 mg once daily. - Symptomatic treatment of gastroesophageal reflux disease without esophagitis: · 20 mg once daily. If symptoms are not controlled after 4 weeks, further medical attention is required. · Once symptoms are alleviated, continued symptoms are controlled with 20 mg once daily. · In adults, 20 mg can be given once daily as needed. In patients at high risk of gastric and duodenal ulcers due to nonsteroidal anti-inflammatory drug use, it is not recommended to administer it as needed for continuous symptom control. 2) Antibiotic combination therapy for Helicobacter pylori eradication This 20 mg of medication should be administered in combination with 1 g of amoxicillin and 500 mg of clarithromycin, 2 times a day for 7 days. 3) Short-term therapy for upper gastrointestinal symptoms (pain, discomfort, burning sensation) related to nonsteroidal anti-inflammatory drug (non-selective and selective COX-2) use - 20 mg once daily. If symptoms are not controlled after 4 weeks, further medical attention is required. Clinical trials have not been conducted beyond 4 weeks. 4) For patients requiring continuous nonsteroidal anti-inflammatory drug use - Treatment of gastric ulcers related to non-steroidal anti-inflammatory drug use: 20 mg once daily for 4 to 8 weeks. - Prevention of gastric and duodenal ulcers related to nonsteroidal anti-inflammatory drug use: 20 mg once daily. 5) Treatment of Zollinger-Ellison syndrome The recommended initial dose is 40 mg twice daily. Subsequent doses should be adjusted based on individual patient needs, and treatment should continue as long as clinical symptoms are present. According to clinical data, most patients can be managed with doses ranging from 80 to 160 mg daily. Doses exceeding 80 mg should be divided into two administrations. 6) Maintenance therapy after intravenous induction for the prevention of rebleeding due to gastric or duodenal ulcers After intravenous induction for prevention of rebleeding due to gastric or duodenal ulcers, administer 40 mg once daily for 4 weeks. 2. For adolescents aged 12 and over 1) Gastroesophageal reflux disease (GERD) - Treatment of erosive esophagitis: 40 mg once daily for 4 weeks. If esophagitis is not treated or symptoms persist, continue for an additional 4 weeks. - Symptomatic treatment of gastroesophageal reflux disease without esophagitis: · 20 mg once daily. If symptoms are not controlled after 4 weeks, further medical attention is required. · Once symptoms are alleviated, continued symptoms are controlled with 20 mg once daily. · In adults, 20 mg can be administered as needed. In patients at high risk of gastric and duodenal ulcers due to nonsteroidal anti-inflammatory drug use, it is not recommended to administer it as needed for continuous symptom control. 3. For children under 12 years: No experience has been reported in administering this medication to children under 12. 4. Renal impairment: Dose adjustment is not necessary. Caution should be exercised as there is limited experience in administering this to patients with severe renal failure. 5. Hepatic impairment: Dose adjustment is not necessary for patients with mild to moderate liver dysfunction. For patients with severe liver dysfunction, the dosage should not exceed 20 mg. 6. In elderly patients: Dose adjustment is not necessary.

Children's dosage

Adolescents aged 12 and over 1) Gastroesophageal reflux disease (GERD) - Treatment of erosive esophagitis: 40 mg once daily for 4 weeks - If esophagitis is not treated or symptoms persist, continue for an additional 4 weeks.

This medication should not be used by patients who are allergic to this drug, its components, or benzimidazole derivatives, or have a history of hypersensitive reactions. Additionally, patients who are allergic to penicillins or macrolide antibiotics should not be given this medication when used in combination with amoxicillin or clarithromycin for the eradication of Helicobacter pylori. This medication should also not be used by patients on certain heart-related medications, antiviral agents, or nursing women. Various adverse reactions may occur while taking this medication, with common symptoms including headache, abdominal pain, diarrhea, nausea, and in rare cases, serious side effects such as blood abnormalities, liver function problems, skin rashes, myalgia, and more. Particularly, long-term use may lead to hypomagnesemia or an increased risk of fractures, hence regular monitoring is necessary. This medication can increase the risk of bacterial infections in the gastrointestinal tract by suppressing gastric acid secretion, so if diarrhea persists, consultation with a healthcare professional is necessary. Furthermore, this medication has a high potential for drug interactions, so patients must inform healthcare providers of all medications they are currently taking, and care should be exercised when used concurrently with warfarin, methotrexate, clopidogrel, and others. Its safety during pregnancy has not been sufficiently established, so careful consideration is required, and it should be avoided during breastfeeding. In case of overdose, as there is no specific antidote, appropriate treatment based on symptoms is important. Finally, keep this medication out of reach of children and avoid transferring it to other containers.

Serious side effects

Urticaria, angioedema, anaphylaxis, shock, severe allergic reactions, severe rash with fever, blistering, skin peeling, oral/ocular mucosal pain, mucocutaneous syndrome (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell syndrome), acute generalised exanthematous pustulosis, drug reaction with eosinophilia and systemic symptoms (DRESS syndrome), severe skin reactions.

Mild side effects

Headache, dizziness, paresthesia, drowsiness, taste disturbance, blurred vision, bronchospasm, abdominal pain, constipation, diarrhea, abdominal bloating, nausea/vomiting, dry mouth, stomatitis, increased liver enzymes, dermatitis, itching, rash, hair loss, photosensitivity, fractures, arthralgia, myalgia, interstitial nephritis, gynecomastia, asthenia, increased sweating, Clostridium difficile-associated diarrhea, allergic reactions, chest pain, facial edema, fatigue, fever, malaise, pain, flushing.

This medication may be sensitive to air or moisture, so it should be stored in a tightly sealed container. The storage temperature should be maintained between 1 degree and 30 degrees Celsius at room temperature to preserve the medication's efficacy.

Appearance

Pink round film-coated tablet

Package unit

28 tablets (14 tablets/PTP X 2)