Nesina Act Tablets 12.5/30 mg

Adult dosage

This medication is taken once daily regardless of meals. The tablets should not be divided. The basic recommended dosages are 25mg/15mg or 25mg/30mg. For patients with renal impairment, mild cases (creatinine clearance ≥50 mL/min) do not require dosage adjustment, while moderate renal impairment (creatinine clearance ≥30 to <50 mL/min) patients should take 12.5 mg/15 mg or 12.5 mg/30 mg once a day.

This medication can put stress on the heart in some patients, potentially causing or worsening a condition known as congestive heart failure. Therefore, after starting this medication or increasing the dosage, careful monitoring for symptoms of heart failure such as sudden weight gain, shortness of breath, or swelling should be carried out. If symptoms of heart failure develop, appropriate medical treatment should be sought immediately, and discontinuation or dosage adjustment of this medication should be considered. This medication should not be used by patients with heart failure and is not recommended for patients with symptoms of heart failure. Since this medication can cause fluid retention, it is crucial to continuously monitor for symptoms of fluid retention or heart failure. Additionally, reports have associated this medication with bladder cancer, so if new or worsening symptoms such as hematuria, urinary disorders, or urgency occur, a doctor should be informed immediately. This medication is contraindicated in patients with hypersensitivity to it or certain diabetes conditions, heart failure, liver dysfunction, severe renal impairment, or active bladder cancer. Patients with renal impairment, premenopausal women, those with edema, or the elderly should use this medication with caution, and dosage adjustments might be necessary when used with other medications that increase the risk of hypoglycemia. This medication can affect liver function, so regular liver function tests should be conducted before and during treatment, and if any symptoms of liver dysfunction occur, healthcare professionals should be informed immediately. During the course of treatment, there may be adverse reactions such as edema, weight gain, increased risk of fractures, vision decline, macular edema, severe joint pain, and blistering skin conditions, so careful attention is required. Women who are pregnant or may become pregnant, and nursing mothers should not use this medication. In case of overdose, appropriate measures should be taken as directed by healthcare professionals, and it should be kept out of reach of children.

Serious side effects

Congestive heart failure, urticaria, severe edema, chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, skin peeling, mouth/eye mucosal pain, severe skin adverse reactions, asthma attacks, respiratory abnormalities accompanied by cough and fever, yellowing of skin or eyes (jaundice), extreme lethargy, liver abnormalities, sudden and severe headaches, thunderclap headache, seizures, confusion, visual disturbances, paralysis

Mild side effects

• Nasopharyngitis
• lower back pain
• upper respiratory infection
• headache
• sinusitis
• myalgia
• pharyngitis
• influenza
• hypoglycemia
• stomatitis

This medication should be stored in a tightly closed container to protect it from air and moisture and is safe to store at room temperature between 1 to 30 degrees Celsius. Proper storage helps maintain the drug's efficacy.

Appearance

Light pink, bilaterally convex, circular film-coated tablets

Package unit

28 tablets/carton