Nexon Tablet 20 mg (Esomeprazole Magnesium Trihydrate)

Adult dosage

This medication should be swallowed with liquid such as water and must not be chewed or crushed. 1. Gastroesophageal reflux disease (GERD) - Treatment of erosive esophagitis: 40 mg once daily for 4 weeks. - If esophagitis is not resolved or symptoms persist, take for another 4 weeks. - Maintenance therapy to prevent recurrence of esophagitis: 20 mg once daily. - Treatment for gastroesophageal reflux disease symptoms without esophagitis: 20 mg once daily; further treatment is required if symptoms are not controlled after 4 weeks. - Once symptoms improve, maintain those symptoms with 20 mg once daily. Adults can take 20 mg as needed every day. Patients at high risk for the development of gastric ulcers and duodenal ulcers due to NSAID administration should not be advised to take rescue therapy for symptom control. 2) Combination antibiotic therapy for Helicobacter pylori eradication Administer 20 mg of this medication in conjunction with amoxicillin 1 g and clarithromycin 500 mg, twice daily for 7 days. 3) Short-term treatment for upper gastrointestinal symptoms (pain, discomfort, burning sensation) related to the administration of non-steroidal anti-inflammatory drugs (non-selective COX-2 and selective) - 20 mg once daily; further consultation is required if symptoms are not controlled after 4 weeks. Clinical trials have not been conducted beyond 4 weeks. 4) For patients requiring continuous administration of non-steroidal anti-inflammatory drugs - The treatment of gastric ulcers related to non-steroidal anti-inflammatory drugs: 20 mg once daily for 4 to 8 weeks. - Prevention of gastric and duodenal ulcers related to non-steroidal anti-inflammatory drug administration: 20 mg once daily. 5) Treatment of Zollinger-Ellison syndrome Recommended initial dose is 40 mg twice daily. The dosage should be adjusted depending on the patient, and treatment should continue as long as there are clinical symptoms. According to clinical data, most patients can be adjusted at a dose of 80 to 160 mg daily. Doses over 80 mg should be divided and taken twice a day. 6) Maintenance therapy after intravenous induction of prevention of rebleeding due to gastric or duodenal ulcers After intravenous induction of prevention of rebleeding due to gastric or duodenal ulcers, administer 40 mg once daily for 4 weeks. 2. Adolescents aged 12 and older 1) Gastroesophageal reflux disease (GERD) - Treatment of erosive esophagitis: 40 mg once daily for 4 weeks. If esophagitis treatment is ineffective or symptoms persist, continue for another 4 weeks. - Symptomatic treatment for gastroesophageal reflux disease without esophagitis: · 20 mg once daily; further consultation is needed if symptoms are not controlled after 4 weeks. · Once symptoms are alleviated, maintain continuous symptoms with 20 mg once daily. · In adults, 20 mg can be administered as needed once daily. Patients at high risk for the development of gastric and duodenal ulcers due to NSAID administration should not be advised to take rescue therapy for symptom control. 3. For children under 12 years: There is no experience of administering this medication to children under 12 years. 4. Renal impairment: There is no need to adjust the dosage. Because there is little experience in administering this medication to patients with severe renal failure, cautious administration is recommended. 5. Hepatic impairment: No dosage adjustment is necessary for mild to moderate liver impairment. Patients with severe liver impairment should not exceed a dose of 20 mg of this medication. 6. Elderly patients: No dosage adjustment is necessary.

Children's dosage

Adolescents aged 12 and older. 1. Gastroesophageal reflux disease (GERD) - Treatment of erosive esophagitis: 40 mg once daily for 4 weeks. - If esophagitis treatment is ineffective or symptoms persist, continue for another 4 weeks.

This medication should not be used in certain patients. For example, it should not be administered to patients with allergies or hypersensitivity to this drug or its components, or to benzimidazole derivatives. Additionally, it should not be used in combination with this medication if there is an allergy to specific antibiotics such as amoxicillin or clarithromycin during Helicobacter pylori eradication therapy. Women with a history of myocardial infarction or those who are breastfeeding are also advised against using this medication. Caution should be exercised as various adverse reactions may occur while taking this medication. Common reactions include headaches, abdominal pain, diarrhea, and nausea, while rare reactions may include blood abnormalities, hypersensitivity reactions, hypomagnesemia, liver function abnormalities, etc. Regular monitoring of serum magnesium levels is recommended especially with long-term use, and patients should consult their doctor immediately if symptoms such as myalgia or weakness occur. This medication can increase the risk of gastrointestinal infections, such as diarrhea, as it suppresses gastric acid secretion, which may increase the proliferation of bacteria in the stomach. Additionally, long-term use may increase the risk of fractures, so patients at risk of osteoporosis are advised to undergo regular bone density assessments. There may be interactions with other medications taken concurrently, particularly with anticoagulants, antiepileptics, antidepressants, and antiviral medications, so it is important to follow the doctor's instructions carefully. The safety of this medication during pregnancy has not been fully established, so it should be administered only after consulting a doctor. It's also advised not to take this medication while breastfeeding. In cases of overdose, there is no specific antidote, so appropriate treatment must be provided according to symptoms, and it should be kept out of reach of children. If a skin rash, severe allergic reactions, or cardiac symptoms occur during the course of taking this medication, immediate medical consultation is required.

Serious side effects

Urticaria, angioedema, anaphylaxis, shock, hypomagnesemia, hypocalcemia, hypokalemia, mental confusion, pancreatitis, hepatitis, jaundice, liver failure, encephalopathy, erythema multiforme, mucocutaneous syndrome (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell syndrome), acute generalized exanthematous pustulosis, drug reaction with eosinophilia and systemic symptoms (DRESS syndrome), nephritis, Clostridium difficile-associated diarrhea.

Mild side effects

Headaches, dizziness, sensory abnormalities, drowsiness, taste disturbances, blurred vision, bronchospasm, abdominal pain, constipation, diarrhea, abdominal bloating, nausea, vomiting, dry mouth, stomatitis, gastrointestinal candidiasis, increased liver enzymes, dermatitis, itching, rashes, hair loss, photosensitivity, erythema multiforme, fractures, arthralgia, myalgia, muscle weakness, nephritis, gynecomastia, asthenia, increased sweating, Clostridium difficile-associated diarrhea, abdominal distension, allergic reactions.

This medication should be stored in a tightly sealed container to prevent air or moisture from entering. Additionally, it is recommended to store the medication at room temperature between 1 to 30 degrees Celsius.

Appearance

Pale pink round film-coated tablet

Package unit

28 tablets (14 tablets/Alu-Alu X2)