Siwonnajeong (Sodium Loxoprofen Hydrate)

Adult dose

1. For efficacy and effects 1, 2: Adults: Administer 60 mg of sodium loxoprofen (anhydrous) orally three times a day. For a single treatment, 60-120 mg can be administered orally. 2. For efficacy and effects 3: Adults: Administer 60 mg of sodium loxoprofen (anhydrous) orally. In principle, it can be given up to twice daily, with a maximum daily dose of 180 mg. Avoid taking on an empty stomach.

Caution is advised for those who regularly consume more than three glasses of alcohol daily, as this medication may increase the risk of gastrointestinal bleeding, and consultation with a physician or pharmacist is required. Non-steroidal anti-inflammatory drugs (NSAIDs) including this medication may increase the risk of cardiovascular or cerebrovascular diseases; therefore, individuals with cardiovascular diseases or risk factors should exercise particular caution. Due to the potential risk of ulcers or bleeding in the gastrointestinal tract, individuals with a history of gastrointestinal disorders or the elderly should carefully monitor for gastrointestinal symptoms while taking this medication. Those with a history of peptic ulcers, severe blood disorders, significantly impaired liver or kidney function, heart failure, late pregnancy, or lactation should avoid using this medication. Individuals who have experienced allergic reactions or asthma related to this medication or NSAIDs in the past should not take this medication. Long-term use of this medication requires regular blood tests, liver function tests, and kidney function tests to check for abnormalities. Taking this medication along with other NSAIDs may increase the risk of side effects, hence it is advisable not to use them together. When used alongside certain medications, the efficacy may change or side effects may increase, so it is important to inform a physician or pharmacist and take it carefully. This medication should not be taken during pregnancy, especially in the late stages, as it can be harmful to the fetus. During early or mid-pregnancy, it should only be taken at minimal doses when absolutely necessary. The safety of this medication in children has not been established, therefore it is advisable not to use it in pediatric cases. Elderly patients should use this medication with greater caution due to a higher risk of side effects. If any unusual symptoms appear during treatment, such as skin rash, difficulty breathing, severe abdominal pain, or bleeding, discontinue and consult medical personnel immediately. This medication should be kept out of reach of children, and it is safer not to transfer it to another container.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, shock, anaphylactic symptoms, peptic ulcer, perforation, hematemesis, melena, bleeding with shock, intestinal perforation, liver dysfunction (including jaundice), fulminant hepatitis, acute renal failure, respiratory distress, asthma attacks, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell syndrome), erythema multiforme, and acute reactions.

Mild side effects

• Rash
• itching
• fever
• abdominal pain
• discomfort in the stomach
• loss of appetite
• nausea
• vomiting
• diarrhea
• constipation

This medication should be stored in a tightly sealed container to protect it from exposure to air or moisture. It is also advisable to store the medicine at room temperature, between 1 to 30 degrees Celsius, avoiding extremely hot or cold places.

Appearance

White round tablet

Package unit

30 tablets/bottle, 100 tablets/bottle