Lodivica Tablets 2.5/40 mg (Amlodipine Nicotinate, Olmesartan Medoxomil)

Adult dose

This medication is taken once daily, with 1 tablet taken with water regardless of meals. It is recommended to take it at the same time each day (e.g., in the morning). The recommended dosages are as follows: - 2.5/20 mg: Given to patients whose blood pressure is not adequately controlled by Amlodipine 2.5 mg or Olmesartan Medoxomil 20 mg monotherapy. - 5/20 mg: Given to patients whose blood pressure is not adequately controlled by Olmesartan Medoxomil 20 mg monotherapy.

Child dose

The safety and efficacy in pediatric patients under 18 years have not been established.

This medication can cause serious harm to the fetus and newborn if taken during the second or third trimester of pregnancy; therefore, it should be discontinued immediately upon confirmation of pregnancy. Patients allergic to any components of this medication or similar drugs, pregnant or breastfeeding women, patients with severe liver or heart disease, or patients undergoing kidney dialysis should not take it. Patients with a deficiency in fluids or salts may experience hypotension, so close monitoring of their condition is required during the initial dosage, and appropriate actions should be taken if hypotension is observed. There is a risk of severe hypotension due to sudden dilation of blood vessels, particularly in patients with aortic stenosis, who should exercise caution. Patients with weakened hearts should be closely monitored for worsening of heart failure symptoms while taking this medication. Patients with impaired kidney function may have their kidney function affected by this medication, so regular kidney function tests should be conducted. Patients with reduced liver function may experience delayed metabolism of this medication, requiring caution during use. Common side effects may include dizziness, headache, hypotension, edema, dyspepsia, rash, etc.; if any unusual symptoms occur, consult a healthcare professional. Interactions may occur when this medication is taken with other drugs, so it is essential to inform healthcare providers of any other medications being taken. Especially, grapefruit juice can excessively enhance the blood pressure-lowering effect, so it is advisable to avoid it. This medication should not be used during pregnancy unless necessary, and if pregnancy is being planned or confirmed, prompt consultation with a healthcare provider is advised. Nursing women should either discontinue breastfeeding or this medication, as it may be transmitted through breast milk. Children under 18 years should refrain from taking this medication as its safety and efficacy have not been established for this age group. Elderly patients, who may have decreased liver, kidney, or heart function, should start on a lower dose and be observed carefully. In cases of overdose, blood pressure may be excessively low or heart rate may increase; immediate medical attention is necessary for appropriate treatment. This medication should be kept out of reach of children and stored away from moisture, heat, and direct sunlight.

Serious side effects

Urticaria, severe swelling (edema), difficulty breathing, severe allergic reactions, severe skin adverse reactions, jaundice (yellowing of skin or eyes), extreme lethargy, liver abnormalities (jaundice), sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis, serious neurological symptoms, significantly reduced urine output, severe generalized swelling with accompanying increased blood pressure, severe edema or urinary changes.

Mild side effects

• Dizziness
• headache
• decreased libido
• drowsiness
• sensory disturbances
• decreased sensation
• palpitations
• rapid pulse
• hypotension
• orthostatic hypotension

This medication may be sensitive to air and moisture, thus it must be stored in a tightly sealed container. Additionally, it is best to keep it at room temperature between 1°C to 30°C, avoiding excessively hot or cold places.

Appearance

Pale yellow round film-coated tablets

Package unit

30 tablets/bottle, 300 tablets/bottle