Coxcare Capsule 200 mg (Celecoxib)

Adult dose

The minimum recommended dose of this medicine should be adjusted according to the patient and may be administered regardless of meals. ○ Adults: 1. Osteoarthritis (degenerative arthritis): Take 200 mg of celecoxib once daily, or 100 mg twice daily. 2. Rheumatoid arthritis: Take 100 mg or 200 mg of celecoxib twice daily. 3. Ankylosing spondylitis (AS): Administer 200 mg of celecoxib once daily, or 100 mg twice daily. If no effect is observed after 6 weeks, a dose of up to 400 mg per day may be administered. If no effect is observed after 6 weeks of taking 400 mg per day, other treatment options should be considered. 4. Acute pain and primary dysmenorrhea: The initial recommended dose is 400 mg of celecoxib, with an additional 200 mg administered on the first day of treatment if needed. From the second day of treatment, the recommended dose, if needed, is 200 mg twice daily. ○ Patients with hepatic impairment: For patients with moderate hepatic impairment (Child-Pugh Class II), the dose should be reduced to approximately 50 % of the recommended daily dose.

This medication should be discussed with a doctor or pharmacist if the patient regularly consumes three or more alcoholic beverages daily, as taking it with alcohol can increase the risk of gastrointestinal bleeding. This medication may increase the risk of cardiovascular diseases and severe problems like myocardial infarction or stroke. These risks can increase depending on the dosage and duration of use, so it should be used at the lowest possible dose and for the shortest duration. It may also affect the gastrointestinal tract, potentially leading to serious issues such as gastric ulcers, bleeding, and perforation. Caution is especially needed for the elderly or those with a history of gastrointestinal disease, and if gastrointestinal symptoms occur, immediate medical attention should be sought. This medication should not be used in patients with a history of certain allergies or severe liver, kidney disease, heart failure, inflammatory bowel disease, pregnant or breastfeeding women. Additionally, patients with certain genetic metabolic disorders should not take it. Patients with liver or kidney problems, as well as those with diseases such as hypertension, asthma, heart failure, and diabetes, should use this medication cautiously and follow regular testing as directed by a physician. While taking this medication, side effects such as headache, indigestion, vomiting, dizziness, skin rash, edema, hypertension (including worsening), cough, gastric ulcers, dental issues, liver enzyme elevation, peripheral edema, facial swelling, flu-like symptoms, damage, upper respiratory infections, sinusitis, pharyngitis, rhinitis, bronchitis, skin rash, hair loss, angioedema, thrombocytopenia, and anemia may occur, so any abnormal symptoms should be reported to healthcare professionals immediately. This medication may interact with other medications, so should be reported to a doctor, especially when taking antihypertensives, anticoagulants, diuretics, antidepressants, or anticancer drugs. Women who are pregnant or may become pregnant should not take this medication, and if pregnancy is confirmed during use, it should be discontinued immediately and a doctor consulted. The elderly should take extra caution as they may have reduced liver and kidney function and should start at the lowest effective dose. During treatment, regular blood tests, liver, and kidney function tests should be conducted to monitor for abnormalities, and if dizziness or drowsiness occurs, driving or operating machinery should be avoided. Overdose may cause vomiting, lethargy, abdominal pain, and in severe cases, renal failure or respiratory depression. Immediate medical attention is required, and there is no specific antidote, so supportive treatment will be provided. This medication should be stored out of the reach of children and not transferred to another container.

Gastrointestinal bleeding, cardiovascular thrombotic reactions, myocardial infarction, cerebrovascular accident, perforation of the upper and lower gastrointestinal tract, ulcer, bleeding, bronchitis, sinusitis, upper respiratory tract infection, urinary tract infection, pharyngitis, rhinitis, anemia, thrombocytopenia, hypersensitivity, insomnia, anxiety, confusion state, dizziness, muscle tension increase, drowsiness, blurred vision, tinnitus, palpitations, congestive heart failure, arrhythmia, tachycardia, hypertension, flushing, cough, vomiting, abdominal pain, diarrhea, dyspepsia, bloating, gastric ulcer, dental disease, duodenal ulcer, esophageal ulcer, intestinal perforation, pancreatitis, elevated liver enzymes, itching, rash, urticaria, petechiae, angioedema, alopecia, bullous dermatitis, peripheral edema, facial edema, influenza-like illness, injury, taste disturbance, albuminuria, cystitis, hematuria, dysuria, polyuria, nephrolithiasis, urinary incontinence, urinary tract infection, blurred vision, cataract, conjunctivitis, eye pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, increased serum creatinine, increased β2-microglobulin, increased NAG, positive urinary hematuria, positive urinary protein, renal dysfunction, acute renal failure, interstitial nephritis, increased serum sodium, increased serum potassium, increased BUN, increased CPK, diabetes mellitus, hypercholesterolemia, hyperglycemia, hypokalemia, hyperkalemia, increased NPN, increased creatinine, increased alkaline phosphatase, weight gain, loss of appetite, increased LDH, hypoglycemia, hyponatremia, bursitis, arthralgia, arthropathy, skeletal abnormalities, myalgia, cervical dystonia, synovitis, tendinitis, myositis, leg cramps, fractures, tendon rupture, pain in the back, muscle rigidity, decreased hematocrit, increased hemoglobin, petechiae, epistaxis, thrombocytopathy, agranulocytosis, aplastic anemia, pancytopenia, leukopenia, vasculitis, contact dermatitis, injection site reaction, skin nodules, headache, leg cramps, sensory diminution, migraine, neuralgia, neuropathy, sensory abnormalities, cerebral infarction, aseptic meningitis, ataxia, suicide, anosmia, ageusia, allergic exacerbation, allergic reaction, muscular weakness, chest pain, fluid retention, generalized edema, facial edema, fatigue, lethargy, fever, facial flushing, influenza-like syndrome, pain, peripheral pain, sepsis, sudden death, anaphylactoid reaction, angioedema, loss of appetite, increased appetite, depression, neuroexcitability, drowsiness, fatal intracranial hemorrhage, hallucinations, exacerbation of epilepsy, upper respiratory tract infection, herpes simplex, wound infection, gingivitis, herpes simplex, shingles, bacterial infection, fungal infection, soft tissue infection, viral infection, moniliasis, genital moniliasis, otitis media, breast tenderness, menopausal symptoms, fibrocystic changes of the breast, thoracic neoplasm, dysmenorrhea, menstrual disorder, vaginal bleeding, vaginitis, prostatic disorders, ovarian cysts, hearing loss, ear abnormalities, otalgia, hearing impairment, liver dysfunction, elevated ALT, elevated AST, increased γ-GTP, increased ALP, positive urinary urobilinogen, cholelithiasis, hepatitis, jaundice, hepatic failure, fulminant hepatitis, hepatic necrosis, vasculitis, pulmonary embolism, interstitial pneumonia, photosensitivity reaction, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, drug rash with eosinophilia and systemic symptoms, acute generalized pustular dermatosis, exfoliative dermatitis, acute renal failure, hyponatremia, tubular interstitial nephritis, nephrotic syndrome, focal segmental glomerulosclerosis, female infertility, chest pain, anaphylactic reaction, hallucinations, cerebral hemorrhage, aseptic meningitis, ageusia, anosmia, conjunctivitis, gastrointestinal bleeding, hepatitis

This medication should be stored in a tightly sealed container to prevent air exposure, and kept in a cool place between 15 to 30 degrees Celsius. Storing it this way will help maintain the medication's effectiveness for a longer period.

Appearance

A white capsule with a yellow band, filled with a white to light yellow powder.

Package unit

30 capsules/bottle