Pidogrel Tablets (Clopidogrel Hydrogen Sulfate)

Adult dose

1. For patients with ischemic stroke, myocardial infarction, or peripheral artery disease, clopidogrel is administered orally at a dose of 75 mg once daily. 2. For acute coronary syndrome patients, a loading dose of 300 mg is given orally once daily on the first day, followed by a maintenance dose of 75 mg once daily. At this time, aspirin 75-325 mg should also be taken once daily. 3. For patients with atrial fibrillation, clopidogrel is administered orally at a dose of 75 mg once daily.

This medication helps prevent platelets from aggregating, allowing blood to flow properly. Individuals with genetically reduced function of a specific enzyme (CYP2C19) may experience decreased effectiveness of this medication, so alternative treatment options should be considered in such cases. If medications that activate specific enzymes are taken together with this drug, the concentration of this drug may increase, raising the risk of bleeding, so it is advisable to avoid co-administration. Patients who are allergic to this drug or its components, have active bleeding, have severely impaired liver function, are nursing, or have lactose intolerance should not take this medication. Patients at high risk for bleeding or those scheduled for surgery should consult their doctor before taking this drug and may need to stop taking it 5-7 days prior to surgery. This medication inhibits blood coagulation and may cause bleeding; if bleeding symptoms occur, notify a doctor immediately. Caution should be exercised when taking this drug with other medications that increase bleeding risk (e.g., aspirin, warfarin, non-steroidal anti-inflammatory drugs, selective serotonin reuptake inhibitors, etc.). During treatment with this drug, symptoms such as gastrointestinal bleeding, rash, headache, dizziness, diarrhea, nausea, abdominal pain, fatigue, rash, pruritus, ecchymosis/bruising, epistaxis, hematoma, hematuria, urinary tract infection, upper respiratory infection, cough, rhinitis, bronchitis, depression, insomnia, anxiety, myalgia, arthralgia, low back pain, weight gain, weight loss, facial flushing, loss of appetite, vomiting, hiccups, dry mouth, dysphagia, forgetfulness, and abnormal thoughts may occur; consult a doctor if any of these abnormal symptoms arise. The risk to the fetus during pregnancy is unclear; however, do not discontinue treatment in emergency situations such as myocardial infarction or stroke. Nursing mothers should consider discontinuing breastfeeding or the medication as this drug may be excreted in breast milk. Elderly patients or those with impaired renal or liver function have a higher risk of bleeding and require dose adjustments and careful monitoring. In cases of overdose, the risk of bleeding may increase, and as there is no specific antidote, platelet transfusion may be required to prevent bleeding. This medication should be stored out of reach of children for their safety and it is advisable not to transfer it to other containers.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, skin peeling, pain in mouth/eyes mucosa, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough and fever, yellowing of skin or eyes (jaundice), extreme lethargy, sudden and severe headache, thunderclap headache, seizure, confusion, visual disturbances, paralysis, urination problems

Mild side effects

• Headache
• dizziness
• dyspepsia
• diarrhea
• nausea
• abdominal pain
• fatigue
• rash
• pruritus
• ecchymosis/bruising

This medication should be stored in a tightly closed container to prevent exposure to air and moisture. Additionally, it is best to store it at room temperature, which should ideally be between 1 and 30 degrees Celsius, avoiding extreme heat or cold.

Appearance

Pink round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle