DIAZEN Capsule (Diacerein)

Adult dose

Adults: Administer 50∼100mg of diacerein orally in 1∼2 divided doses daily after meals. The dose may be adjusted as appropriate according to symptoms. For patients with a history of loose stools or diarrhea, an initial dose of 50mg once daily for the first 2-4 weeks is recommended, followed by 50mg twice daily.

This medication should not be administered to patients suffering from inflammatory bowel diseases. For example, patients with ulcerative colitis or Crohn's disease should avoid the use of this medication. Additionally, this medication should not be given to patients with intestinal obstruction syndrome or those experiencing unexplained abdominal pain. Individuals who are hypersensitive to this drug, any of its ingredients, or Rhein-related medications should not use it. Patients with liver disease or those who have a history of liver disease should also refrain from using this medication. This medication should not be used in children under 15 years of age. As this drug contains lactose, it should not be administered to patients with lactose intolerance or specific genetic metabolic disorders. Patients with a history of small intestine or colon diseases should use this medication cautiously, and special care is required for pregnant or breastfeeding women. Elderly individuals aged 65 years or older should use a reduced dosage of this medication. Moreover, patients who are allergic or hypersensitive to Yellow No. 5, included in this medication, should take it with caution. This medication may cause gastrointestinal side effects such as diarrhea, loose stools, and abdominal pain, and prolonged use may lead to serious issues like gastrointestinal bleeding, ulcers, and perforation. If diarrhea becomes severe, dehydration and electrolyte imbalance may occur; should such symptoms arise, discontinue use immediately and consult a doctor. Skin symptoms such as itching, rash, or eczema may develop as allergic reactions. As this medication may affect liver function, if there is an increase in liver enzyme levels or signs of liver damage, discontinue use and consult a specialist. When used long-term, follow the physician's instructions strictly, and immediately stop use if diarrhea occurs. This medication may interfere with the absorption when taken with antacids containing calcium, magnesium, or aluminum; thus, it is recommended to keep a gap of more than 2 hours between doses. Caution should be exercised when using diuretics as it may enhance diuretic effects, increasing the risk of dehydration and hypokalemia. Furthermore, when used concurrently with cardiac glycosides, there may be an increased risk of arrhythmias, so consultation with a physician is necessary. During pregnancy, it is advisable not to use this medication as it may affect fetal bone formation, and breastfeeding women should also avoid it due to the potential transfer of the drug through breast milk. In the event of overdose, severe diarrhea may occur, requiring appropriate treatment such as electrolyte supplementation.

• Diarrhea
• loose stools
• abdominal pain
• gastrointestinal disorders
• bleeding
• ulcers
• perforation
• rectal mucosal pigmentation
• dehydration
• fluid and electrolyte imbalance

This medication may be sensitive to air and moisture; therefore, it should be stored in a tightly sealed container. It is recommended to keep the storage temperature between 1 degree and 30 degrees Celsius at room temperature. Proper storage will help maintain its efficacy for an extended period.

Appearance

A hard capsule with a dark yellow content, upper part yellow, lower part light yellow

Package unit

30 capsules/bottle, 500 capsules/bottle