Nexzol 40 mg (Esomeprazole Magnesium Trihydrate)

Adult dosage

This medication should be taken with liquids such as water and should not be chewed or crushed. 1) Treatment of gastroesophageal reflux disease (GERD) erosive reflux esophagitis: 40 mg once daily for 4 weeks. If symptoms persist, an additional 4 weeks is required. Maintenance therapy to prevent recurrence in esophagitis patients: 20 mg once daily. Treatment of symptoms in gastroesophageal reflux disease without esophagitis: 20 mg once daily.

Children's dosage

Adolescents aged 12 years and older 1) Treatment of gastroesophageal reflux disease with erosive reflux esophagitis: 40 mg once daily for 4 weeks. If symptoms persist, additional 4 weeks is necessary. Treatment of gastroesophageal reflux disease without esophagitis.

This medication should not be administered to certain patients. For instance, patients with an allergy or hypersensitivity to this medication or its ingredients, or benzimidazoles should not use it. Additionally, patients who have hypersensitivity to certain antibiotics used in combination during Helicobacter pylori eradication therapy should not take this medication. Caution is especially needed for those allergic to penicillin-based antibiotics or macrolide antibiotics. This medication is also not to be administered to patients with a specific history of heart disease or to nursing women. While taking this medication, various adverse reactions may occur. Gastrointestinal symptoms such as headache, abdominal pain, diarrhea, nausea, and vomiting have been frequently reported, and rarely blood disorders, hypersensitivity reactions, skin rashes, and myalgia can occur. Long-term use may lead to electrolyte disturbances like hypomagnesemia; thus, regular testing is required. In severe cases, muscle-related conditions like rhabdomyolysis can occur, so immediate consultation with healthcare professionals is advised if muscle pain or weakness appears. This medication can mask symptoms of malignancy; therefore, if warning symptoms such as weight loss or recurrent vomiting are present, consult a doctor immediately. It is crucial to verify abnormalities through regular checks during long-term use. Additionally, this medication lowers gastric acidity, which may increase the risk of some bacterial infections; therefore, inform healthcare providers if diarrhea persists. This medication may interact with other drugs, especially when taken with antiviral agents, anticoagulants, or anticonvulsants; thus caution is needed. Changes in drug concentrations may increase the risk of side effects or decrease therapeutic effect, so it should be taken according to a doctor's instructions. Data on the use of this medication during pregnancy is limited; therefore, if pregnant, consult a doctor before deciding on its use. It is advisable not to use this medication while breastfeeding as it may pass into breast milk. In case of overdose, there is no specific antidote; treatment should be symptomatic and include general management. Finally, this medication should be kept out of the reach of children, and it is important to store it in the original container to ensure safety and quality.

Serious side effects

Hives, angioedema, anaphylaxis, shock, severe allergic reactions, rash with high fever, blisters, skin peeling, pain in oral/ocular mucosa, Stevens-Johnson syndrome, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, DRESS syndrome, liver failure, jaundice, encephalopathy, hepatic abnormalities, sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis, severe neurological symptoms

Mild side effects

• Headache
• dizziness
• sensory disturbances
• drowsiness
• taste disorder
• blurred vision
• bronchospasm
• abdominal pain
• constipation
• diarrhea

This medication should be stored in a tightly closed container to protect it from air and moisture. It is recommended to keep the storage temperature between 1 and 30 degrees Celsius at room temperature. This will help maintain the efficacy of the medication for a longer period.

Appearance

Pink round film-coated tablets

Package unit

28 tablets (14 tablets/PTP packaging x 2)