Amed Tablet (Glymepiride)

Adult dose

Take orally once daily. It should be taken before breakfast or immediately before the first meal. The initial dose is started at 1 mg, and it is increased by 1 mg at intervals of 1 to 2 weeks. Generally, no additional effect is observed with doses above 4 mg, although some patients may increase to 6 mg or 8 mg. If 4 mg per day fails, consider switching to insulin therapy or combining with additional insulin.

This medication should not be used in patients with insulin-dependent diabetes or those with diabetic ketoacidosis or coma. Additionally, patients with allergies to this medication or sulfonylurea drugs, as well as those with severe liver or kidney dysfunction, should not use it. Women who are pregnant or breastfeeding are advised not to take this medication, and patients with severe infections, before and after surgery, or those who have suffered major trauma are recommended to switch to insulin treatment. Patients with gastrointestinal disturbances should be cautious as they may have issues absorbing food, increasing the risk of hypoglycemia. Patients with genetic lactose intolerance or lactase enzyme deficiency should also refrain from taking this medication. During the initial dosages, there is a high risk of hypoglycemia, so blood glucose levels must be monitored very carefully, especially in patients with poor nutritional status, irregular eating patterns, frequent alcohol consumers, those with impaired liver or kidney function, and the elderly. Symptoms of hypoglycemia can vary and may include headaches, severe hunger, nausea, fatigue, confusion, lowered consciousness, etc., so immediate consumption of sugar is necessary if symptoms occur. Serious side effects such as liver function abnormalities, blood abnormalities, and allergic reactions can occur very rarely, so patients should consult their doctor immediately if any unusual symptoms arise. During treatment with this medication, it is important to maintain a regular diet and exercise regimen, and to be prepared to consume sugar immediately in the event of hypoglycemia. If taken with other medications, it may affect blood glucose control, so all medications being taken should be disclosed to the doctor. In the case of pregnancy or breastfeeding, insulin treatment is preferred instead of this medication, and its safety and efficacy have not been verified in children under 18 years of age. Elderly patients may have reduced kidney function, so care must be taken in adjusting dosages. In cases of overdose, severe hypoglycemia may occur, so immediate hospital treatment should be sought for appropriate care.

Serious side effects

• Severe allergic reactions: Hives
• Severe skin adverse reactions: Stevens-Johnson Syndrome
• Respiratory issues: Difficulty breathing
• Liver issues (jaundice): Abnormal liver function, jaundice, hepatitis
• Severe neurological symptoms: Seizures, coma
• Severe edema or urination abnormalities: Severe edema accompanied by high blood pressure
• Blood disorders: Thrombocytopenia, leukopenia, hemolytic anemia, erythrocytopenia, agranulocytosis, pancytopenia, thrombocytopenia

Mild side effects

• Symptoms of hypoglycemia: headaches, severe hunger, nausea, vomiting, fatigue, sleep disturbances, anxiety, aggression, decreased concentration, reduced motivation, depression, confusion, speech abnormalities, aphasia, visual disturbances, tremor, partial paralysis, sensory disturbances, dizziness, weakness, loss of self-control, temporary mental confusion, seizures, drowsiness, shallow breathing, bradycardia, etc.
• Eyes: Temporary visual disturbances such as blurred vision
• Gastrointestinal: Nausea, vomiting, upper abdominal fullness, stomach ache,

This medication should be stored in a tightly sealed container to protect it from air and moisture. It is recommended to maintain a storage temperature between 1 and 30 degrees Celsius at room temperature.

Appearance

Green oblong tablet

Package unit

30 tablets/bottle, 100 tablets/bottle, 500 tablets/bottle