Celodipine Tablets (Amlodipine Besilate)

Adult dose

Administer 5 mg of amlodipine orally once daily, and may increase to a maximum of 10 mg per day based on the patient's response. Dosing should be adequately adjusted according to age and symptoms.

This medication should not be used in specific patients. For example, patients who have had allergic reactions to this drug or similar medications, nursing mothers, patients with severe liver dysfunction, those with severe aortic stenosis, and patients in a state of shock should not be administered this medication. Moreover, it should be used cautiously in patients with very low blood pressure, those requiring dialysis due to renal failure, the elderly, and pregnant women or women who may become pregnant. This medication is generally well-tolerated, but side effects such as flushing, fatigue, edema, palpitations, dizziness, headache, drowsiness, abdominal pain, and nausea may occur. Rarely, side effects like hypotension, vasculitis, neurological symptoms, erectile dysfunction, gynecomastia, gastrointestinal issues, blood abnormalities, and skin rashes have also been reported. Caution should be exercised in patients with heart failure or liver dysfunction, as this drug can remain in the body for an extended period and its hypotensive effect may persist; when stopping the medication and beginning another antihypertensive, dosages and intervals should be adjusted accordingly. This medication is not expected to provide quick effects in emergencies and reportedly does not significantly impact driving or machine operation ability. When taken with other medications, there may be interactions, particularly with certain antibiotics, antihypertensives, grapefruit juice, and some immunosuppressants; caution is necessary when combining these. Grapefruit juice can excessively enhance the effect of this medication, so it is advisable not to take them together. The safety of this medication during pregnancy has not been established, so it should only be used in special cases; it is recommended to discontinue breastfeeding when taking this medication. In children, it is recommended for ages 6 and over, as efficacy and safety in children under 6 years are not known. In case of overdose, severe hypotension and tachycardia may occur, requiring immediate treatment, and it is difficult to remove the drug through hemodialysis. If symptoms are severe, active cardiovascular supportive therapy may be necessary.

Serious side effects

Hives, severe swelling (angioedema), difficulty breathing, skin peeling, pain in oral/ocular mucous membranes, toxic epidermal necrolysis, skin rash, severe allergic reactions, respiratory distress, jaundice, liver abnormalities, sudden and severe headaches, seizures, syncope, confusion, visual disturbances, paralysis, significantly reduced urine output, severe systemic swelling and increased blood pressure.

Mild side effects

• Flushing
• fatigue
• edema
• palpitations
• dizziness
• headache
• drowsiness
• abdominal pain
• nausea
• weakness

Store this medication in a tightly sealed container to prevent exposure to air or moisture. It is advisable to maintain a storage temperature between 1 degree and 30 degrees Celsius at room temperature. Storing it this way helps ensure the medication's effectiveness is safely preserved.

Appearance

White octagonal tablets

Package unit

30 tablets/bottle, 300 tablets/bottle