Newpex Duo Tablets 5mg/10mg

Adult dose

Amlodipine (as esamlodipine) is usually administered orally once daily at a dose of 5(2.5) mg, which may be increased to a maximum of 10(5) mg daily depending on the patient's response. Dosage may be adjusted according to symptoms. The recommended initial dose of atorvastatin is 10 mg once daily; for patients requiring greater reductions in LDL cholesterol levels, treatment can start with 20 mg or 40 mg once daily. This medication is administered once daily.

This medication should not be used in certain patients. For example, patients with allergies to this medication or similar drugs, severely impaired liver function, active liver diseases, pregnant women or women who may become pregnant, breastfeeding women, patients with muscular diseases, patients with severe aortic stenosis, patients in shock, patients within one month after a myocardial infarction, patients with unstable angina, and patients taking specific antiviral agents should not be administered this medication. Moreover, patients with severely impaired renal function, elderly individuals, patients with a history of alcohol abuse or liver diseases, patients at high risk for muscle damage, patients with acute heart failure, patients in hypertensive crisis, patients with mild to moderate liver dysfunction, and patients with severe myasthenia gravis should use this medication cautiously. This medication is primarily composed of two ingredients and is generally well tolerated, but some patients may experience symptoms such as flushing due to vasodilation, fatigue, edema, palpitations, dizziness, headache, drowsiness, abdominal pain, and nausea. Additionally, rare side effects such as myalgia, muscle cramps, hepatic dysfunction, allergic reactions, skin rashes, hair loss, insomnia, and coughing have been reported. One of the components of this medication is metabolized in the liver, so patients with impaired liver function require regular liver function tests, and the medication should be discontinued if any liver dysfunction is detected. Moreover, if muscle-related abnormal symptoms appear, the physician should be notified immediately, and if severe muscle pain or muscle weakness occurs, the medication should be stopped. This medication may interact with other drugs, particularly certain antibiotics, antifungals, immunosuppressants, some antivirals, and grapefruit juice, requiring caution when used concurrently. Pregnant or breastfeeding women should not take this medication, and women of childbearing potential should use appropriate contraception while taking this medication. The safety in pediatric and elderly populations has not been sufficiently confirmed, so caution is needed in these groups. In case of overdose, symptoms such as decreased blood pressure and cardiac dysfunction may appear, necessitating immediate medical attention. This medication should be kept out of reach of children and should not be transferred to other containers.

Serious side effects

• Urticaria
• angioedema
• toxic epidermal necrolysis
• severe edema
• chest tightness
• dyspnea
• jaundice
• hepatitis
• profound lethargy
• severe allergic reactions

Mild side effects

• Flushing
• fatigue
• edema
• palpitations
• dizziness
• headache
• drowsiness
• abdominal pain
• nausea
• weakness

This medication should be stored in a tightly sealed container to protect it from air and moisture, and it is best kept in a cool place between 15 and 30 degrees Celsius. This way, the effectiveness of the medication can be well maintained.

Appearance

White oval film-coated tablet

Package unit

For Domestic Use: 30 tablets/bottle For Export: 30 tablets (10 tablets/PTP X 3)